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The Journal of Immunology, 2001, 167: 5531-5534.
Copyright © 2001 by The American Association of Immunologists

Cutting Edge

Cutting Edge: A Major Fraction of Human Bone Marrow Lymphocytes Are Th2-Like CD1d-Reactive T Cells That Can Suppress Mixed Lymphocyte Responses1

Mark A. Exley2,*, Syed Muhammad Ali Tahir*, Olivia Cheng*, Angela Shaulov*, Robin Joyce*,{dagger}, David Avigan*,{dagger}, Robert Sackstein{ddagger},§,¶ and Steven P. Balk*

* Cancer Biology Program, Hematology/Oncology, Beth Israel-Deaconess Medical Center, {dagger} Bone Marrow Transplant Program, {ddagger} Harvard Skin Disease Research Center, Harvard Medical School, Boston, MA 02115; § Bone Marrow Transplant Program, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114; and Departments of Dermatology and Medicine, Brigham & Women’s Hospital, Boston, MA 02115

Murine bone marrow (BM) NK T cells can suppress graft-vs-host disease, transplant rejection, and MLRs. Human BM contains T cells with similar potential. Human BM was enriched for NK T cells, ~50% of which recognized the nonpolymorphic CD1d molecule. In contrast to the well-characterized blood-derived CD1d-reactive invariant NK T cells, the majority of human BM CD1d-reactive T cells used diverse TCR. Healthy donor invariant NK T cells rapidly produce large amounts of IL-4 and IFN-{gamma} and can influence Th1/Th2 decision-making. Healthy donor BM CD1d-reactive T cells were Th2-biased and suppressed MLR and, unlike the former, responded preferentially to CD1d+ lymphoid cells. These results identify a novel population of human T cells which may contribute to B cell development and/or maintain Th2 bias against autoimmune T cell responses against new B cell Ag receptors. Distinct CD1d-reactive T cell populations have the potential to suppress graft-vs-host disease and stimulate antitumor responses.




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