| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
*
Laboratory of Cellular Immunology, Alton Ochsner Medical Foundation, New Orleans, LA 70121; and
Department of Immunology and Cell Biology, Forschungszentrum Borstel, Borstel, Germany
Germinal center-B (GC-B) cells differentiate into memory B cells and plasma cells (PC) through interaction with T cells and follicular dendritic cells (FDC). Activated T cell and FDC play distinct roles in this process. The detailed kinetic experiments revealed that cytokines secreted by activated T cells determined the pathway of GC-B cell differentiation. IL-4 directs GC-B cells to differentiate into memory B cells, whereas IL-10 steers them into PC. FDC/HK cells do not direct either pathway, but provide signals for proliferation of GC-B cells. A novel FDC-signaling molecule 8D6 (FDC-SM-8D6) produced by FDC augments PC generation in the GC. FDC-SM-8D6-specific mAb blocked PC generation and IgG secretion but not memory B cell proliferation. COS cells expressing FDC-SM-8D6 enhanced GC-B cell proliferation and Ab secretion, which was blocked by mAb 8D6. In the cultures with B cell subsets, PC generation was inhibited by mAb 8D6 in the cultures with CD27+ B cells but not in the culture with CD27- B cells, suggesting that CD27+ PC precursor is the specific target of FDC-SM-8D6 stimulation.
This article has been cited by other articles:
|
|
 |
|
  S.-O. Yoon, X. Zhang, P. Berner, B. Blom, and Y. S. Choi Notch Ligands Expressed by Follicular Dendritic Cells Protect Germinal Center B Cells from Apoptosis J. Immunol., July 1, 2009; 183(1): 352 - 358. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. V. Quadros, Y. Nakayama, and J. M. Sequeira The protein and the gene encoding the receptor for the cellular uptake of transcobalamin-bound cobalamin Blood, January 1, 2009; 113(1): 186 - 192. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-J. Goval, C. Thielen, C. Bourguignon, R. Greimers, E. Dejardin, Y. S. Choi, J. Boniver, and L. de Leval The prevention of spontaneous apoptosis of follicular lymphoma B cells by a follicular dendritic cell line: involvement of caspase-3, caspase-8 and c-FLIP Haematologica, August 1, 2008; 93(8): 1169 - 1177. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Murakami, X. Chen, K. Hase, A. Sakamoto, C. Nishigaki, and H. Ohno Splenic CD19 CD35+B220+ cells function as an inducer of follicular dendritic cell network formation Blood, August 15, 2007; 110(4): 1215 - 1224. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Nishikawa, M. Hikida, M. Magari, N. Kanayama, M. Mori, H. Kitamura, T. Kurosaki, and H. Ohmori Establishment of Lymphotoxin beta Receptor Signaling-Dependent Cell Lines with Follicular Dendritic Cell Phenotypes from Mouse Lymph Nodes J. Immunol., October 15, 2006; 177(8): 5204 - 5214. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Zhang, C.-S. Park, S.-O. Yoon, L. Li, Y.-M. Hsu, C. Ambrose, and Y. S. Choi BAFF supports human B cell differentiation in the lymphoid follicles through distinct receptors Int. Immunol., June 1, 2005; 17(6): 779 - 788. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Huber, C. Thielen, H. Seeger, P. Schwarz, F. Montrasio, M. R. Wilson, E. Heinen, Y.-X. Fu, G. Miele, and A. Aguzzi Lymphotoxin-{beta} Receptor-Dependent Genes in Lymph Node and Follicular Dendritic Cell Transcriptomes J. Immunol., May 1, 2005; 174(9): 5526 - 5536. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Gatto, T. Pfister, A. Jegerlehner, S. W. Martin, M. Kopf, and M. F. Bachmann Complement receptors regulate differentiation of bone marrow plasma cell precursors expressing transcription factors Blimp-1 and XBP-1 J. Exp. Med., March 21, 2005; 201(6): 993 - 1005. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Elleder, D. C. Melder, K. Trejbalova, J. Svoboda, and M. J. Federspiel Two Different Molecular Defects in the Tva Receptor Gene Explain the Resistance of Two tvar Lines of Chickens to Infection by Subgroup A Avian Sarcoma and Leukosis Viruses J. Virol., December 15, 2004; 78(24): 13489 - 13500. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-S. Park, S.-O. Yoon, R. J. Armitage, and Y. S. Choi Follicular Dendritic Cells Produce IL-15 That Enhances Germinal Center B Cell Proliferation in Membrane-Bound Form J. Immunol., December 1, 2004; 173(11): 6676 - 6683. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. P. Plackett, E. D. Boehmer, D. E. Faunce, and E. J. Kovacs Aging and innate immune cells J. Leukoc. Biol., August 1, 2004; 76(2): 291 - 299. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Li, S.-O. Yoon, D.-D. Fu, X. Zhang, and Y. S. Choi Novel follicular dendritic cell molecule, 8D6, collaborates with CD44 in supporting lymphomagenesis by a Burkitt lymphoma cell line, L3055 Blood, August 1, 2004; 104(3): 815 - 821. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. V. Acosta-Rodriguez, C. L. Montes, C. C. Motran, E. I. Zuniga, F.-T. Liu, G. A. Rabinovich, and A. Gruppi Galectin-3 Mediates IL-4-Induced Survival and Differentiation of B Cells: Functional Cross-Talk and Implications during Trypanosoma cruzi Infection J. Immunol., January 1, 2004; 172(1): 493 - 502. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-C. Wong, E. Oh, C.-H. Ng, and K.-P. Lam Impaired germinal center formation and recall T-cell-dependent immune responses in mice lacking the costimulatory ligand B7-H2 Blood, August 15, 2003; 102(4): 1381 - 1388. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. V. Acosta Rodriguez, E. Zuniga, C. L. Montes, and A. Gruppi Interleukin-4 biases differentiation of B cells from Trypanosoma cruzi-infected mice and restrains their fratricide: role of Fas ligand down-regulation and MHC class II-transactivator up-regulation J. Leukoc. Biol., January 1, 2003; 73(1): 127 - 136. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K N Potter, C I Mockridge, A Rahman, S Buchan, T Hamblin, B Davidson, D A Isenberg, and F K Stevenson Disturbances in peripheral blood B cell subpopulations in autoimmune patients Lupus, December 1, 2002; 11(12): 872 - 877. [Abstract] [PDF]
|
|
|
|
|
|
T. Beyer, M. Meyer-Hermann, and G. Soff A possible role of chemotaxis in germinal center formation Int. Immunol., December 1, 2002; 14(12): 1369 - 1381. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Jung, A.-K. Yi, X. Zhang, J. Choe, L. Li, and Y. S. Choi Distinct Response of Human B Cell Subpopulations in Recognition of an Innate Immune Signal, CpG DNA J. Immunol., September 1, 2002; 169(5): 2368 - 2373. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Marshall, Q. Du, K. E. Draves, Y. Shikishima, K. T. HayGlass, and E. A. Clark FDC-SP, a Novel Secreted Protein Expressed by Follicular Dendritic Cells J. Immunol., September 1, 2002; 169(5): 2381 - 2389. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Johansson-Lindbom and C. A. K. Borrebaeck Germinal Center B Cells Constitute a Predominant Physiological Source of IL-4: Implication for Th2 Development In Vivo J. Immunol., April 1, 2002; 168(7): 3165 - 3172. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
