The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Zhang, X.
Right arrow Articles by Choi, Y. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Zhang, X.
Right arrow Articles by Choi, Y. S.
The Journal of Immunology, 2001, 167: 49-56.
Copyright © 2001 by The American Association of Immunologists

The Distinct Roles of T Cell-Derived Cytokines and a Novel Follicular Dendritic Cell-Signaling Molecule 8D6 in Germinal Center-B Cell Differentiation

Xin Zhang1,*, Li Li1,*, Jaeho Jung*, Shulin Xiang*, Christiane Hollmann{dagger} and Yong Sung Choi2,*

* Laboratory of Cellular Immunology, Alton Ochsner Medical Foundation, New Orleans, LA 70121; and {dagger} Department of Immunology and Cell Biology, Forschungszentrum Borstel, Borstel, Germany

Germinal center-B (GC-B) cells differentiate into memory B cells and plasma cells (PC) through interaction with T cells and follicular dendritic cells (FDC). Activated T cell and FDC play distinct roles in this process. The detailed kinetic experiments revealed that cytokines secreted by activated T cells determined the pathway of GC-B cell differentiation. IL-4 directs GC-B cells to differentiate into memory B cells, whereas IL-10 steers them into PC. FDC/HK cells do not direct either pathway, but provide signals for proliferation of GC-B cells. A novel FDC-signaling molecule 8D6 (FDC-SM-8D6) produced by FDC augments PC generation in the GC. FDC-SM-8D6-specific mAb blocked PC generation and IgG secretion but not memory B cell proliferation. COS cells expressing FDC-SM-8D6 enhanced GC-B cell proliferation and Ab secretion, which was blocked by mAb 8D6. In the cultures with B cell subsets, PC generation was inhibited by mAb 8D6 in the cultures with CD27+ B cells but not in the culture with CD27- B cells, suggesting that CD27+ PC precursor is the specific target of FDC-SM-8D6 stimulation.




This article has been cited by other articles:


Home page
 BloodHome page
T. Murakami, X. Chen, K. Hase, A. Sakamoto, C. Nishigaki, and H. Ohno
Splenic CD19 CD35+B220+ cells function as an inducer of follicular dendritic cell network formation
Blood, August 15, 2007; 110(4): 1215 - 1224.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
Y. Nishikawa, M. Hikida, M. Magari, N. Kanayama, M. Mori, H. Kitamura, T. Kurosaki, and H. Ohmori
Establishment of Lymphotoxin beta Receptor Signaling-Dependent Cell Lines with Follicular Dendritic Cell Phenotypes from Mouse Lymph Nodes
J. Immunol., October 15, 2006; 177(8): 5204 - 5214.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
X. Zhang, C.-S. Park, S.-O. Yoon, L. Li, Y.-M. Hsu, C. Ambrose, and Y. S. Choi
BAFF supports human B cell differentiation in the lymphoid follicles through distinct receptors
Int. Immunol., June 1, 2005; 17(6): 779 - 788.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C. Huber, C. Thielen, H. Seeger, P. Schwarz, F. Montrasio, M. R. Wilson, E. Heinen, Y.-X. Fu, G. Miele, and A. Aguzzi
Lymphotoxin-{beta} Receptor-Dependent Genes in Lymph Node and Follicular Dendritic Cell Transcriptomes
J. Immunol., May 1, 2005; 174(9): 5526 - 5536.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Med.Home page
D. Gatto, T. Pfister, A. Jegerlehner, S. W. Martin, M. Kopf, and M. F. Bachmann
Complement receptors regulate differentiation of bone marrow plasma cell precursors expressing transcription factors Blimp-1 and XBP-1
J. Exp. Med., March 21, 2005; 201(6): 993 - 1005.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
D. Elleder, D. C. Melder, K. Trejbalova, J. Svoboda, and M. J. Federspiel
Two Different Molecular Defects in the Tva Receptor Gene Explain the Resistance of Two tvar Lines of Chickens to Infection by Subgroup A Avian Sarcoma and Leukosis Viruses
J. Virol., December 15, 2004; 78(24): 13489 - 13500.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C.-S. Park, S.-O. Yoon, R. J. Armitage, and Y. S. Choi
Follicular Dendritic Cells Produce IL-15 That Enhances Germinal Center B Cell Proliferation in Membrane-Bound Form
J. Immunol., December 1, 2004; 173(11): 6676 - 6683.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
T. P. Plackett, E. D. Boehmer, D. E. Faunce, and E. J. Kovacs
Aging and innate immune cells
J. Leukoc. Biol., August 1, 2004; 76(2): 291 - 299.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
L. Li, S.-O. Yoon, D.-D. Fu, X. Zhang, and Y. S. Choi
Novel follicular dendritic cell molecule, 8D6, collaborates with CD44 in supporting lymphomagenesis by a Burkitt lymphoma cell line, L3055
Blood, August 1, 2004; 104(3): 815 - 821.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
E. V. Acosta-Rodriguez, C. L. Montes, C. C. Motran, E. I. Zuniga, F.-T. Liu, G. A. Rabinovich, and A. Gruppi
Galectin-3 Mediates IL-4-Induced Survival and Differentiation of B Cells: Functional Cross-Talk and Implications during Trypanosoma cruzi Infection
J. Immunol., January 1, 2004; 172(1): 493 - 502.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
S.-C. Wong, E. Oh, C.-H. Ng, and K.-P. Lam
Impaired germinal center formation and recall T-cell-dependent immune responses in mice lacking the costimulatory ligand B7-H2
Blood, August 15, 2003; 102(4): 1381 - 1388.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
E. V. Acosta Rodriguez, E. Zuniga, C. L. Montes, and A. Gruppi
Interleukin-4 biases differentiation of B cells from Trypanosoma cruzi-infected mice and restrains their fratricide: role of Fas ligand down-regulation and MHC class II-transactivator up-regulation
J. Leukoc. Biol., January 1, 2003; 73(1): 127 - 136.
[Abstract] [Full Text] [PDF]

Home page
 LupusHome page
K N Potter, C I Mockridge, A Rahman, S Buchan, T Hamblin, B Davidson, D A Isenberg, and F K Stevenson
Disturbances in peripheral blood B cell subpopulations in autoimmune patients
Lupus, December 1, 2002; 11(12): 872 - 877.
[Abstract] [PDF]

Home page
 Int ImmunolHome page
T. Beyer, M. Meyer-Hermann, and G. Soff
A possible role of chemotaxis in germinal center formation
Int. Immunol., December 1, 2002; 14(12): 1369 - 1381.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. Jung, A.-K. Yi, X. Zhang, J. Choe, L. Li, and Y. S. Choi
Distinct Response of Human B Cell Subpopulations in Recognition of an Innate Immune Signal, CpG DNA
J. Immunol., September 1, 2002; 169(5): 2368 - 2373.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. J. Marshall, Q. Du, K. E. Draves, Y. Shikishima, K. T. HayGlass, and E. A. Clark
FDC-SP, a Novel Secreted Protein Expressed by Follicular Dendritic Cells
J. Immunol., September 1, 2002; 169(5): 2381 - 2389.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
B. Johansson-Lindbom and C. A. K. Borrebaeck
Germinal Center B Cells Constitute a Predominant Physiological Source of IL-4: Implication for Th2 Development In Vivo
J. Immunol., April 1, 2002; 168(7): 3165 - 3172.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 2001 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 2001 by The American Association of Immunologists, Inc. All rights reserved.