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Department of Immunology and Host Defenses, Ehime University School of Medicine, Ehime, Japan
We analyzed the mechanism that causes suppression of IL-12 p40 gene
induction during Plasmodium berghei
infection. Although IL-12 together with IFN-
plays an important role
in protection against pathogenic infection, the IL-12 p70 protein
production of infected macrophages is lower than that by the uninfected
macrophages. We showed in the present study that the induction of IL-12
p40 gene but not IL-12 p35 gene in macrophages of P.
berghei-infected mice was profoundly inhibited. The inhibition
was induced by interaction with macrophages that had contacted with
P. berghei-infected erythrocytes and was mediated by a
soluble factor, IL-10. There was comparable activation of NF-
B in
uninfected and infected cells. The induction of IFN-regulatory factor-1
gene was comparable in transcription level in uninfected and infected
cells, while the unidentified complex formation of IFN-regulatory
factor-1 was observed in infected cells. Therefore, the inhibition of
the IL-12 p40 gene induction appeared to be regulated at
transcriptional regulation level of the gene.
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