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*
University of Birmingham/Medical Research Council Centre for Immune Regulation, University of Birmingham, Birmingham, United Kingdom;
Millennium Pharmaceuticals, Cambridge, MA 02139; and
Department of Clinical Immunology, Royal Free Hospital, London, United Kingdom
Using HLA class I-viral epitope tetramers to monitor herpes
virus-specific CD8+ T cell responses in humans, we have
shown that a significant fraction of responding cells revert from a
CD45RO+ to a CD45RA+ state after priming. All
tetramer-binding CD45RA+ cells, regardless of epitope
specificity, expressed a phenotype
LFA-1highCCR7low that was stable for at least
10 years in infectious mononucleosis patients and indefinitely in
asymptomatic carriers.
CD8+CD45RA+LFA-1high cells were not
present in cord blood but in adults account for up to 50% of
CD8+CD45RA+ cells. These
CD45RA+LFA-1high cells have significantly
shorter telomeres than CD45RA+LFA-1low cells,
suggesting that the latter represent a naive population, while the
former are memory cells. CD45RA+ memory cells are a stable
population of noncycling cells, but on stimulation they are potent
producers of IFN-
, while naive CD8+ cells produce only
IL-2. The chemokine receptor profile and migratory potential of
CD45RA+ memory cells is very similar to CD45RO+
cells but different to naive CD8 cells. In accord with this,
CD45RA+ memory cells were significantly underrepresented in
lymph nodes, but account for virtually all
CD8+CD45RA+ T cells in peripheral tissues of
the same individuals.
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