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CUTTING EDGE |
Kimmel Cancer Center and Department of Microbiology and Immunology, Jefferson Medical College, Philadelphia, PA 19107
Immunization of mice containing mutations that inactivate the
TCR C
and C
genes with the T
cell-independent (TI) type 2 Ag (4-hydroxy-3-nitrophenyl)acetyl-Ficoll
induces clusters of peanut agglutinin-binding B cells in the spleen.
These clusters are histologically indistinguishable from germinal
centers (GCs) typical of T cell-dependent immune responses. They are
located in follicles, and contain mature follicular dendritic cells,
immune complex deposits, and B cells that display the phenotypic
qualities of conventional GC B cells. However, the kinetics of this TI
GC response differ from T cell-dependent GC responses in being rapidly
induced and of short duration. Moreover, the Ab V genes expressed in TI
GCs have not undergone somatic hypermutation. Therefore, T cells may be
required for B cell differentiation processes associated with the
intermediate and latter stages of the GC reaction, but they are
dispensable for the induction and initial development of this
response.
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