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CUTTING EDGE |
-Chain Is an Indispensable Subunit of the IL-21 Receptor Complex1
*
Department of Microbiology and Immunology, Tohoku University Graduate School of Medicine, Sendai, Japan;
Department of Pediatric Oncology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan;
Department of Functional Cloning, ZymoGenetics, Seattle, WA 98102; and
Core Research for Evolutional Science and Technology of the Japan Science and Technology Corporation, Tokyo, Japan
The common 
-chain (c) is an
indispensable subunit of the functional receptor complexes for IL-4,
IL-7, IL-9, and IL-15 as well as IL-2. Here we show that the
c is also shared with the IL-21R complex. Although IL-21
binds to the IL-21R expressed on c-deficient
ED40515- cells, IL-21 is unable to transduce any
intracytoplasmic signals. However, in ED-16 cells, a
c-transfected ED40515- cell line, IL-21
binds to the IL-21R and can activate Janus kinase (JAK)1, JAK3, STAT1,
and STAT3. The chemical cross-linking study reveals the direct binding
of IL-21 to the c. These data clearly demonstrate that
the c is an indispensable subunit of the functional
IL-21R complex.
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