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T Cells in Bovine Tuberculosis1
TB Research Group, Veterinary Laboratories Agency, Surrey, United Kingdom
This report describes the in vitro proliferative responses of
peripheral blood 
T cells to defined mycobacterial protein Ags
and the immunomodulatory effect of T cells in cattle infected
with Mycobacterium bovis. T cell responses were
specific to M. bovis infection because they were detected
in cattle either experimentally or naturally infected with M.
bovis, but were not present in uninfected controls. Proliferating
T cell cultures produced enhanced levels of IFN- and TGF-
,
but not IL-2 in response to the more immunodominant mycobacterial Ags.
Depletion of T cells from PBMC resulted in an increased
Ag-specific proliferation in half the animals tested, indicating a
suppressive effect of T cells upon other (
) T cell
responses. Because T cells constitute a major T cell population
in the peripheral blood of cattle, the activities of T cells
described in this report could make a significant contribution to the
immune response in bovine tuberculosis.
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