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The Journal of Immunology, 2001, 166: 5327-5330.
Copyright © 2001 by The American Association of Immunologists

CUTTING EDGE

Cutting Edge: Intravenous Soluble Antigen Is Presented to CD4 T Cells by CD8- Dendritic Cells, but Cross-Presented to CD8 T Cells by CD8+ Dendritic Cells1

Joanne L. Pooley, William R. Heath and Ken Shortman2

Immunology Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia

Mouse spleen contains three distinct mature dendritic cell (DC) populations (CD4+8-, CD4-8-, and CD4-8+) which retain a capacity to take up particulate and soluble Ags. Although the three splenic DC subtypes showed similar uptake of injected soluble OVA, they differed markedly in their capacity to present this Ag and activate proliferation in OVA-specific CD4 or CD8 T cells. For class II MHC-restricted presentation to CD4 T cells, the CD8- DC subtypes were more efficient, but for class I MHC-restricted presentation to CD8 T cells, the CD8+ DC subtype was far more effective. This differential persisted when the DC were activated with LPS. The CD8+ DC are therefore specialized for in vivo cross-presentation of exogenous soluble Ags into the class I MHC presentation pathway.




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Signal 3 Determines Tolerance versus Full Activation of Naive CD8 T Cells: Dissociating Proliferation and Development of Effector Function
J. Exp. Med., May 5, 2003; 197(9): 1141 - 1151.
[Abstract] [Full Text] [PDF]

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S. K. Datta, V. Redecke, K. R. Prilliman, K. Takabayashi, M. Corr, T. Tallant, J. DiDonato, R. Dziarski, S. Akira, S. P. Schoenberger, et al.
A Subset of Toll-Like Receptor Ligands Induces Cross-presentation by Bone Marrow-Derived Dendritic Cells
J. Immunol., April 15, 2003; 170(8): 4102 - 4110.
[Abstract] [Full Text] [PDF]

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M. Dalod, T. Hamilton, R. Salomon, T. P. Salazar-Mather, S. C. Henry, J. D. Hamilton, and C. A. Biron
Dendritic Cell Responses to Early Murine Cytomegalovirus Infection: Subset Functional Specialization and Differential Regulation by Interferon {alpha}/{beta}
J. Exp. Med., April 7, 2003; 197(7): 885 - 898.
[Abstract] [Full Text] [PDF]

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E. Donskoy and I. Goldschneider
Two Developmentally Distinct Populations of Dendritic Cells Inhabit the Adult Mouse Thymus: Demonstration by Differential Importation of Hematogenous Precursors Under Steady State Conditions
J. Immunol., April 1, 2003; 170(7): 3514 - 3521.
[Abstract] [Full Text] [PDF]

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P. Kleindienst and T. Brocker
Endogenous Dendritic Cells Are Required for Amplification of T Cell Responses Induced by Dendritic Cell Vaccines In Vivo
J. Immunol., March 15, 2003; 170(6): 2817 - 2823.
[Abstract] [Full Text] [PDF]

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K. P. A. MacDonald, V. Rowe, C. Filippich, R. Thomas, A. D. Clouston, J. K. Welply, D. N. J. Hart, J. L. M. Ferrara, and G. R. Hill
Donor pretreatment with progenipoietin-1 is superior to granulocyte colony-stimulating factor in preventing graft-versus-host disease after allogeneic stem cell transplantation
Blood, March 1, 2003; 101(5): 2033 - 2042.
[Abstract] [Full Text] [PDF]

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X. Zhao, E. Deak, K. Soderberg, M. Linehan, D. Spezzano, J. Zhu, D. M. Knipe, and A. Iwasaki
Vaginal Submucosal Dendritic Cells, but Not Langerhans Cells, Induce Protective Th1 Responses to Herpes Simplex Virus-2
J. Exp. Med., January 20, 2003; 197(2): 153 - 162.
[Abstract] [Full Text] [PDF]

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 Int ImmunolHome page
P. Castiglioni, C. Lu, D. Lo, M. Croft, P. Langlade-Demoyen, M. Zanetti, and M. Gerloni
CD4 T cell priming in dendritic cell-deficient mice
Int. Immunol., January 1, 2003; 15(1): 127 - 136.
[Abstract] [Full Text] [PDF]

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J. Valenzuela, C. Schmidt, and M. Mescher
The Roles of IL-12 in Providing a Third Signal for Clonal Expansion of Naive CD8 T Cells
J. Immunol., December 15, 2002; 169(12): 6842 - 6849.
[Abstract] [Full Text] [PDF]

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J. M.M. den Haan and M. J. Bevan
Constitutive versus Activation-dependent Cross-Presentation of Immune Complexes by CD8+ and CD8- Dendritic Cells In Vivo
J. Exp. Med., September 16, 2002; 196(6): 817 - 827.
[Abstract] [Full Text] [PDF]

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E. Ingulli, D. R. Ulman, M. M. Lucido, and M. K. Jenkins
In Situ Analysis Reveals Physical Interactions Between CD11b+ Dendritic Cells and Antigen-Specific CD4 T Cells After Subcutaneous Injection of Antigen
J. Immunol., September 1, 2002; 169(5): 2247 - 2252.
[Abstract] [Full Text] [PDF]

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A. T. Kamath, S. Henri, F. Battye, D. F. Tough, and K. Shortman
Developmental kinetics and lifespan of dendritic cells in mouse lymphoid organs
Blood, August 13, 2002; 100(5): 1734 - 1741.
[Abstract] [Full Text] [PDF]

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U. Yrlid and M. J. Wick
Antigen Presentation Capacity and Cytokine Production by Murine Splenic Dendritic Cell Subsets upon Salmonella Encounter
J. Immunol., July 1, 2002; 169(1): 108 - 116.
[Abstract] [Full Text] [PDF]

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Y. Wang, Y. Zhang, H. Yoneyama, N. Onai, T. Sato, and K. Matsushima
Identification of CD8alpha +CD11c- lineage phenotype-negative cells in the spleen as committed precursor of CD8alpha + dendritic cells
Blood, June 28, 2002; 100(2): 569 - 577.
[Abstract] [Full Text] [PDF]

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O. Schulz, D. J. Pennington, K. Hodivala-Dilke, M. Febbraio, and C. Reis e Sousa
CD36 or {alpha}v{beta}3 and {alpha}v{beta}5 Integrins Are Not Essential for MHC Class I Cross-Presentation of Cell-Associated Antigen by CD8{alpha}+ Murine Dendritic Cells
J. Immunol., June 15, 2002; 168(12): 6057 - 6065.
[Abstract] [Full Text] [PDF]

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G. T. Belz, D. Vremec, M. Febbraio, L. Corcoran, K. Shortman, F. R. Carbone, and W. R. Heath
CD36 Is Differentially Expressed by CD8+ Splenic Dendritic Cells But Is Not Required for Cross-Presentation In Vivo
J. Immunol., June 15, 2002; 168(12): 6066 - 6070.
[Abstract] [Full Text] [PDF]

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C. S. Schmidt and M. F. Mescher
Peptide Antigen Priming of Naive, But Not Memory, CD8 T Cells Requires a Third Signal That Can Be Provided by IL-12
J. Immunol., June 1, 2002; 168(11): 5521 - 5529.
[Abstract] [Full Text] [PDF]

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G. Moron, P. Rueda, I. Casal, and C. Leclerc
CD8{alpha}2 CD11b+ Dendritic Cells Present Exogenous Virus-like Particles to CD8+ T Cells and Subsequently Express CD8{alpha} and CD205 Molecules
J. Exp. Med., May 20, 2002; 195(10): 1233 - 1245.
[Abstract] [Full Text] [PDF]

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T. Iyoda, S. Shimoyama, K. Liu, Y. Omatsu, Y. Akiyama, Y. Maeda, K. Takahara, R. M. Steinman, and K. Inaba
The CD8+ Dendritic Cell Subset Selectively Endocytoses Dying Cells in Culture and In Vivo
J. Exp. Med., May 20, 2002; 195(10): 1289 - 1302.
[Abstract] [Full Text] [PDF]

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R. J. Steptoe, J. M. Ritchie, and L. C. Harrison
Increased Generation of Dendritic Cells from Myeloid Progenitors in Autoimmune-Prone Nonobese Diabetic Mice
J. Immunol., May 15, 2002; 168(10): 5032 - 5041.
[Abstract] [Full Text] [PDF]

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A. D. McLellan, M. Kapp, A. Eggert, C. Linden, U. Bommhardt, E.-B. Brocker, U. Kammerer, and E. Kampgen
Anatomic location and T-cell stimulatory functions of mouse dendritic cell subsets defined by CD4 and CD8 expression
Blood, March 15, 2002; 99(6): 2084 - 2093.
[Abstract] [Full Text] [PDF]

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Y. Valdez, W. Mah, M. M. Winslow, L. Xu, P. Ling, and S. E. Townsend
Major Histocompatibility Complex Class II Presentation of Cell-associated Antigen Is Mediated by CD8{alpha}+ Dendritic Cells In Vivo
J. Exp. Med., March 11, 2002; 195(6): 683 - 694.
[Abstract] [Full Text] [PDF]

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M. Dalod, T. P. Salazar-Mather, L. Malmgaard, C. Lewis, C. Asselin-Paturel, F. Briere, G. Trinchieri, and C. A. Biron
Interferon {alpha}/{beta} and Interleukin 12 Responses to Viral Infections: Pathways Regulating Dendritic Cell Cytokine Expression In Vivo
J. Exp. Med., February 19, 2002; 195(4): 517 - 528.
[Abstract] [Full Text] [PDF]

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P. J. O'Connell, W. Li, Z. Wang, S. M. Specht, A. J. Logar, and A. W. Thomson
Immature and Mature CD8{alpha}+ Dendritic Cells Prolong the Survival of Vascularized Heart Allografts
J. Immunol., January 1, 2002; 168(1): 143 - 154.
[Abstract] [Full Text] [PDF]

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L. Wu, A. D'Amico, H. Hochrein, M. O'Keeffe, K. Shortman, and K. Lucas
Development of thymic and splenic dendritic cell populations from different hemopoietic precursors
Blood, December 1, 2001; 98(12): 3376 - 3382.
[Abstract] [Full Text] [PDF]

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W. Asavaroengchai, Y. Kotera, and J. J. Mule
Tumor lysate-pulsed dendritic cells can elicit an effective antitumor immune response during early lymphoid recovery
PNAS, January 22, 2002; 99(2): 931 - 936.
[Abstract] [Full Text] [PDF]


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