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+, and Double-Negative Peyer’s Patch Dendritic Cells1
Immune Cell Interaction Unit, Mucosal Immunity Section, Laboratory of Clinical Investigation, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892
We have recently demonstrated the presence of three populations of
dendritic cells (DC) in the murine Peyer’s patch.
CD11b+/CD8
- (myeloid) DCs are localized in
the subepithelial dome, CD11b-/CD8+
(lymphoid) DCs in the interfollicular regions, and
CD11b-/CD8- (double-negative; DN) DCs at
both sites. We now describe the presence of a novel population of
intraepithelial DN DCs within the follicle-associated epithelium and
demonstrate a predominance of DN DCs only in mucosal lymphoid tissues.
Furthermore, we demonstrate that all DC subpopulations maintain their
surface phenotype upon maturation in vitro, and secrete a distinct
pattern of cytokines upon exposure to T cell and microbial stimuli.
Only myeloid DCs from the PP produce high levels of IL-10 upon
stimulation with soluble CD40 ligand- trimer, or
Staphylococcus aureus and IFN-
. In contrast, lymphoid
and DN, but not myeloid DCs, produce IL-12p70 following microbial
stimulation, whereas no DC subset produces IL-12p70 in response to CD40
ligand trimer. Finally, we show that myeloid DCs from the PP are
particularly capable of priming naive T cells to secrete high levels of
IL-4 and IL-10, when compared with those from nonmucosal sites, while
lymphoid and DN DCs from all tissues prime for IFN- production.
These findings thus suggest that DC subsets within mucosal tissues have
unique immune inductive capacities.
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