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CUTTING EDGE |
*
Laboratory of Immunology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224; and
Experimental Immunology Branch, National Cancer Institute, and National Institute on Aging, National Institutes of Health, Bethesda, MD 20892
Capacity for cellular replication is critically important for lymphocyte function and can be regulated by telomerase-dependent maintenance of telomere length. In contrast to most normal human somatic cells that do not express telomerase due to the failure to transcribe telomerase reverse transcriptase (hTERT), lymphocytes express telomerase in a highly regulated fashion yet constitutively transcribe hTERT during development and activation. Here, we report that hTERT protein is present in both thymocytes and blood T cells at equivalent levels despite their substantial differences in telomerase activity, and that induction of telomerase activity in resting CD4+ T cells is not dependent on net hTERT protein increase. Moreover, hTERT is phosphorylated and translocated from cytoplasm to nucleus during CD4+ T cell activation. Thus, human T lymphocytes regulate telomerase function through novel events independent of hTERT protein levels, and hTERT phosphorylation and nuclear translocation may play a role in regulation of telomerase function in lymphocytes.
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K. Liu, M. Catalfamo, Y. Li, P. A. Henkart, and N.-p. Weng IL-15 mimics T cell receptor crosslinking in the induction of cellular proliferation, gene expression, and cytotoxicity in CD8+ memory T cells PNAS, April 30, 2002; 99(9): 6192 - 6197. [Abstract] [Full Text] [PDF]
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 J.-L. Mergny, J.-F. Riou, P. Mailliet, M.-P. Teulade-Fichou, and E. Gilson Natural and pharmacological regulation of telomerase Nucleic Acids Res., February 15, 2002; 30(4): 839 - 865. [Abstract] [Full Text] [PDF]
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B. N. Armbruster, S. S. R. Banik, C. Guo, A. C. Smith, and C. M. Counter N-Terminal Domains of the Human Telomerase Catalytic Subunit Required for Enzyme Activity in Vivo Mol. Cell. Biol., November 15, 2001; 21(22): 7775 - 7786. [Abstract] [Full Text] [PDF]
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W. C. Hahn Telomerase and Cancer: Where and When? Clin. Cancer Res., October 1, 2001; 7(10): 2953 - 2954. [Full Text] [PDF]
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K. S. J. Elenitoba-Johnson Complex Regulation of Telomerase Activity : Implications for Cancer Therapy Am. J. Pathol., August 1, 2001; 159(2): 405 - 410. [Full Text]
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K. Liu, M. Catalfamo, Y. Li, P. A. Henkart, and N.-p. Weng IL-15 mimics T cell receptor crosslinking in the induction of cellular proliferation, gene expression, and cytotoxicity in CD8+ memory T cells PNAS, April 30, 2002; 99(9): 6192 - 6197. [Abstract] [Full Text] [PDF]
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