| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
MediCity Research Laboratory, Turku University, and National Public Health Institute, Turku, Finland
Reactive arthritis can be triggered by inflammatory bowel diseases.
We hypothesized that migration of mucosal immune cells from inflamed
gut to joints could contribute to the development of reactive
arthritis. Here we isolated gut-derived leukocytes from patients with
Crohn’s disease and ulcerative colitis. Using function-blocking mAbs
and in vitro frozen section adhesion assays we studied whether these
cells bind to synovial vessels and which molecules mediate the
interaction. The results showed that mucosal leukocytes from
inflammatory bowel diseased gut bind well to venules in synovial
membrane. Small intestinal lymphocytes adhered to synovial vessels
using multiple homing receptors and their corresponding endothelial
ligands (CD18-ICAM-1,
4
7/41-integrin-VCAM-1,
L-selectin-peripheral lymph node addressins, and CD44). Of these, only
ICAM-1 significantly supported binding of immunoblasts. In contrast,
P-selectin glycoprotein ligand-1-P-selectin interaction accounted for
practically all synovial adherence of mucosal macrophages. In addition,
blocking of vascular adhesion protein-1 significantly inhibited binding
of all these leukocyte subsets to joint vessels. We conclude that
different leukocyte populations derived from inflamed gut bind avidly
to synovial vessels using distinct repertoire of adhesion molecules,
suggesting that their recirculation may contribute to the development
of reactive arthritis in inflammatory bowel
diseases.
This article has been cited by other articles:
|
|
 |
|
  C. S. Bonder, S. R. Clark, M. U. Norman, P. Johnson, and P. Kubes Use of CD44 by CD4+ Th1 and Th2 lymphocytes to roll and adhere Blood, June 15, 2006; 107(12): 4798 - 4806. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Garrood, L. Lee, and C. Pitzalis Molecular mechanisms of cell recruitment to inflammatory sites: general and tissue-specific pathways Rheumatology, March 1, 2006; 45(3): 250 - 260. [Full Text] [PDF]
|
|
|
|
 |
|
 D Laukens, H Peeters, D Marichal, B Vander Cruyssen, H Mielants, D Elewaut, P Demetter, C Cuvelier, M Van Den Berghe, P Rottiers, et al. CARD15 gene polymorphisms in patients with spondyloarthropathies identify a specific phenotype previously related to Crohn's disease Ann Rheum Dis, June 1, 2005; 64(6): 930 - 935. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Habtezion, D. M. Toivola, E. C. Butcher, and M. B. Omary Keratin-8-deficient mice develop chronic spontaneous Th2 colitis amenable to antibiotic treatment J. Cell Sci., May 1, 2005; 118(9): 1971 - 1980. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Inoue, Y. Tsuzuki, K. Matsuzaki, H. Matsunaga, J. Miyazaki, R. Hokari, Y. Okada, A. Kawaguchi, S. Nagao, K. Itoh, et al. Blockade of PSGL-1 attenuates CD14+ monocytic cell recruitment in intestinal mucosa and ameliorates ileitis in SAMP1/Yit mice J. Leukoc. Biol., March 1, 2005; 77(3): 287 - 295. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Van Assche and P. Rutgeerts Physiological Basis for Novel Drug Therapies Used to Treat the Inflammatory Bowel Diseases I. Immunology and therapeutic potential of antiadhesion molecule therapy in inflammatory bowel disease Am J Physiol Gastrointest Liver Physiol, February 1, 2005; 288(2): G169 - G174. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H Peeters, B Vander Cruyssen, D Laukens, P Coucke, D Marichal, M Van Den Berghe, C Cuvelier, E Remaut, H Mielants, F De Keyser, et al. Radiological sacroiliitis, a hallmark of spondylitis, is linked with CARD15 gene polymorphisms in patients with Crohn's disease Ann Rheum Dis, September 1, 2004; 63(9): 1131 - 1134. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. M. Rijcken, M. G. Laukoetter, C. Anthoni, S. Meier, R. Mennigen, H.-U. Spiegel, M. Bruewer, N. Senninger, D. Vestweber, and C. F. Krieglstein Immunoblockade of PSGL-1 attenuates established experimental murine colitis by reduction of leukocyte rolling Am J Physiol Gastrointest Liver Physiol, July 1, 2004; 287(1): G115 - G124. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Colmegna, R. Cuchacovich, and L. R. Espinoza HLA-B27-Associated Reactive Arthritis: Pathogenetic and Clinical Considerations Clin. Microbiol. Rev., April 1, 2004; 17(2): 348 - 369. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M Cutolo, A Sulli, P Ghiorzo, C Pizzorni, C Craviotto, and B Villaggio Anti-inflammatory effects of leflunomide on cultured synovial macrophages from patients with rheumatoid arthritis Ann Rheum Dis, April 1, 2003; 62(4): 297 - 302. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J Sibilia and F-X Limbach Reactive arthritis or chronic infectious arthritis? Ann Rheum Dis, July 1, 2002; 61(7): 580 - 587. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. Khan Update on Spondyloarthropathies Ann Intern Med, June 18, 2002; 136(12): 896 - 907. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Irjala, E.-L. Johansson, R. Grenman, K. Alanen, M. Salmi, and S. Jalkanen Mannose Receptor Is a Novel Ligand for L-Selectin and Mediates Lymphocyte Binding to Lymphatic Endothelium J. Exp. Med., October 15, 2001; 194(8): 1033 - 1042. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
