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Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215
The TCR repertoire of an epitope-specific CD8+ T cell
population remains poorly characterized. To determine the breadth of
the TCR repertoire of a CD8+ T cell population that
recognizes a dominant epitope of the AIDS virus, the CD8+ T
cells recognizing the tetrameric Mamu-A*01/p11C,CM complex
were isolated from simian immunodeficiency virus (SIV)-infected
Mamu-A*01+ rhesus monkeys. This CD8+ T cell
population exhibited selected usage of TCR V
families and
complementarity-determining region 3 (CDR3) segments. Although the
epitope-specific CD8+ T cell response was clearly
polyclonal, a dominance of selected V+ cell
subpopulations and clones was seen in the TCR repertoire.
Interestingly, some of the selected V+ cell
subpopulations and clones maintained their dominance in the TCR
repertoire over time after infection with SIV of macaques. Other
V+ cell subpopulations declined over time in their
relative representation and were replaced by newly evolving clones that
became dominant. The present study provides molecular evidence
indicating that the TCR repertoire shaped by a single viral epitope is
dominated at any point in time by selected V+ cell
subpopulations and clones and suggests that dominant V+
cell subpopulations and clones can either be stable or evolve during a
chronic infection.
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