| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Receptor Ligation1
*
Department of Microbiology and Immunology, Temple University School of Medicine, Philadelphia, PA 19140;
Schering-Plough Laboratory of Immunological Research, Dardilly, France; and
Department of Microbiology and Immunology, Weill Medical College, Cornell University, New York, NY 10021
Ligating Fc
R on macrophages results in suppression of IL-12
production. We show that FcR ligation selectively down-regulates
IL-12 p40 and p35 gene expression at the level of transcription. The
region responsive to this inhibition maps to the Ets site of the p40
promoter. PU.1, IFN consensus sequence binding protein, and
c-Rel form a complex on this element upon macrophage
activation. Receptor ligation abolishes the binding of this
PU.1-containing activation complex, and abrogates p40 transcription. A
dominant-negative construct of PU.1 diminishes IL-12 p40 promoter
activity and endogenous IL-12 p40 protein secretion. Thus, the
specificity of IL-12 down-regulation following receptor ligation lies
in the inhibition of binding of a PU.1-containing complex to the Ets
site of the IL-12 promoter. These findings provide evidence
demonstrating for the first time the importance of PU.1 in the
transcriptional regulation of IL-12 gene
expression.
This article has been cited by other articles:
|
|
 |
|
  S. Divanovic, A. Trompette, L. K. Petiniot, J. L. Allen, L. M. Flick, Y. Belkaid, R. Madan, J. J. Haky, and C. L. Karp Regulation of TLR4 signaling and the host interface with pathogens and danger: the role of RP105 J. Leukoc. Biol., August 1, 2007; 82(2): 265 - 271. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. K. Polumuri, V. Y. Toshchakov, and S. N. Vogel Role of Phosphatidylinositol-3 Kinase in Transcriptional Regulation of TLR-Induced IL-12 and IL-10 by Fc{gamma} Receptor Ligation in Murine Macrophages J. Immunol., July 1, 2007; 179(1): 236 - 246. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Ma, S. Mishra, K. Gee, J. P. Mishra, D. Nandan, N. E. Reiner, J. B. Angel, and A. Kumar Cyclosporin A and FK506 Inhibit IL-12p40 Production through the Calmodulin/Calmodulin-dependent Protein Kinase-activated Phosphoinositide 3-Kinase in Lipopolysaccharide-stimulated Human Monocytic Cells J. Biol. Chem., May 4, 2007; 282(18): 13351 - 13362. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. W. Moore, A. R. Cruz, C. J. LaVake, A. L. Marzo, C. H. Eggers, J. C. Salazar, and J. D. Radolf Phagocytosis of Borrelia burgdorferi and Treponema pallidum Potentiates Innate Immune Activation and Induces Gamma Interferon Production Infect. Immun., April 1, 2007; 75(4): 2046 - 2062. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. M. Townsend, I. Gonzalez-Gomez, and J. L. Badger fliP influences Citrobacter koseri macrophage uptake, cytokine expression and brain abscess formation in the neonatal rat. J. Med. Microbiol., December 1, 2006; 55(Pt 12): 1631 - 1640. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Cao, X. Zhang, J. P. Edwards, and D. M. Mosser NF-{kappa}B1 (p50) Homodimers Differentially Regulate Pro- and Anti-inflammatory Cytokines in Macrophages J. Biol. Chem., September 8, 2006; 281(36): 26041 - 26050. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. D. Iankov, M. Pandey, M. Harvey, G. E. Griesmann, M. J. Federspiel, and S. J. Russell Immunoglobulin g antibody-mediated enhancement of measles virus infection can bypass the protective antiviral immune response. J. Virol., September 1, 2006; 80(17): 8530 - 8540. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Liu and X. Ma Interferon Regulatory Factor 8 Regulates RANTES Gene Transcription in Cooperation with Interferon Regulatory Factor-1, NF-{kappa}B, and PU.1 J. Biol. Chem., July 14, 2006; 281(28): 19188 - 19195. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Ito, H. Kanzler, O. Duramad, W. Cao, and Y.-J. Liu Specialization, kinetics, and repertoire of type 1 interferon responses by human plasmacytoid predendritic cells Blood, March 15, 2006; 107(6): 2423 - 2431. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Fronhofer, M. R. Lennartz, and D. J. Loegering Role of PKC isoforms in the Fc{gamma}R-mediated inhibition of LPS-stimulated IL-12 secretion by macrophages J. Leukoc. Biol., February 1, 2006; 79(2): 408 - 415. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. N. Waggoner, M. W. Cruise, R. Kassel, and Y. S. Hahn gC1q Receptor Ligation Selectively Down-Regulates Human IL-12 Production through Activation of the Phosphoinositide 3-Kinase Pathway J. Immunol., October 1, 2005; 175(7): 4706 - 4714. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Lucas, X. Zhang, V. Prasanna, and D. M. Mosser ERK Activation Following Macrophage Fc{gamma}R Ligation Leads to Chromatin Modifications at the IL-10 Locus J. Immunol., July 1, 2005; 175(1): 469 - 477. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Laine, J. M. Bourhis, S. Longhi, M. Flacher, L. Cassard, B. Canard, C. Sautes-Fridman, C. Rabourdin-Combe, and H. Valentin Measles virus nucleoprotein induces cell-proliferation arrest and apoptosis through NTAIL-NR and NCORE-Fc{gamma}RIIB1 interactions, respectively J. Gen. Virol., June 1, 2005; 86(6): 1771 - 1784. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Ji, J. Masterson, J. Sun, and L. Soong CD4+CD25+ Regulatory T Cells Restrain Pathogenic Responses during Leishmania amazonensis Infection J. Immunol., June 1, 2005; 174(11): 7147 - 7153. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Qin, J. C. Edberg, A. W. Gibson, G. P. Page, L. Teng, and R. P. Kimberly Differential Gene Expression Modulated by the Cytoplasmic Domain of Fc{gamma}RIa (CD64) {alpha}-Chain J. Immunol., November 15, 2004; 173(10): 6211 - 6219. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. C. Marie, F. Saltel, J.-M. Escola, P. Jurdic, T. F. Wild, and B. Horvat Cell Surface Delivery of the Measles Virus Nucleoprotein: a Viral Strategy To Induce Immunosuppression J. Virol., November 1, 2004; 78(21): 11952 - 11961. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Xiong, H. Li, Y. Chen, J. Zhao, and J. C. Unkeless Interaction of TRAF6 with MAST205 Regulates NF-{kappa}B Activation and MAST205 Stability J. Biol. Chem., October 15, 2004; 279(42): 43675 - 43683. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Mitsuhashi, J. Liu, S. Cao, X. Shi, and X. Ma Regulation of interleukin-12 gene expression and its anti-tumor activities by prostaglandin E2 derived from mammary carcinomas J. Leukoc. Biol., August 1, 2004; 76(2): 322 - 332. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. H. Sulahian, P. A. Pioli, K. Wardwell, and P. M. Guyre Cross-linking of Fc{gamma}R triggers shedding of the hemoglobin-haptoglobin scavenger receptor CD163 J. Leukoc. Biol., July 1, 2004; 76(1): 271 - 277. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Schmidt, J. Bies, T. Tamura, K. Ozato, and L. Wolff The interferon regulatory factor ICSBP/IRF-8 in combination with PU.1 up-regulates expression of tumor suppressor p15Ink4b in murine myeloid cells Blood, June 1, 2004; 103(11): 4142 - 4149. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Zhou, H. Xiong, H. Li, S. E. Plevy, P. D. Walden, M. Sassaroli, G. D. Prestwich, and J. C. Unkeless Microtubule-Associated Serine/Threonine Kinase-205 kDa and Fc{gamma} Receptor Control IL-12 p40 Synthesis and NF-{kappa}B Activation J. Immunol., February 15, 2004; 172(4): 2559 - 2568. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. L. Oleszak, J. R. Chang, H. Friedman, C. D. Katsetos, and C. D. Platsoucas Theiler's Virus Infection: a Model for Multiple Sclerosis Clin. Microbiol. Rev., January 1, 2004; 17(1): 174 - 207. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Romani, C. Montagnoli, S. Bozza, K. Perruccio, A. Spreca, P. Allavena, S. Verbeek, R. A. Calderone, F. Bistoni, and P. Puccetti The exploitation of distinct recognition receptors in dendritic cells determines the full range of host immune relationships with Candida albicans Int. Immunol., January 1, 2004; 16(1): 149 - 161. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Liu, S. Cao, L. M. Herman, and X. Ma Differential Regulation of Interleukin (IL)-12 p35 and p40 Gene Expression and Interferon (IFN)-{gamma}-primed IL-12 Production by IFN Regulatory Factor 1 J. Exp. Med., October 20, 2003; 198(8): 1265 - 1276. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Zhu, K. Rao, H. Xiong, K. Gagnidze, F. Li, C. Horvath, and S. Plevy Activation of the Murine Interleukin-12 p40 Promoter by Functional Interactions between NFAT and ICSBP J. Biol. Chem., October 10, 2003; 278(41): 39372 - 39382. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-D. Ji, I. Tassiulas, K.-H. Park-Min, A. Aydin, I. Mecklenbrauker, A. Tarakhovsky, L. Pricop, J. E. Salmon, and L. B. Ivashkiv Inhibition of Interleukin 10 Signaling after Fc Receptor Ligation and during Rheumatoid Arthritis J. Exp. Med., June 2, 2003; 197(11): 1573 - 1583. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Verbovetski, H. Bychkov, U. Trahtemberg, I. Shapira, M. Hareuveni, O. Ben-Tal, I. Kutikov, O. Gill, and D. Mevorach Opsonization of Apoptotic Cells by Autologous iC3b Facilitates Clearance by Immature Dendritic Cells, Down-regulates DR and CD86, and Up-regulates CC Chemokine Receptor 7 J. Exp. Med., December 16, 2002; 196(12): 1553 - 1561. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Cao, J. Liu, M. Chesi, P. L. Bergsagel, I-C. Ho, R. P. Donnelly, and X. Ma Differential Regulation of IL-12 and IL-10 Gene Expression in Macrophages by the Basic Leucine Zipper Transcription Factor c-Maf Fibrosarcoma J. Immunol., November 15, 2002; 169(10): 5715 - 5725. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Zhao, C. A. Cuff, E. Moss, U. Wille, T. Cyrus, E. A. Klein, D. Pratico, D. J. Rader, C. A. Hunter, E. Pure, et al. Selective Interleukin-12 Synthesis Defect in 12/15-Lipoxygenase-deficient Macrophages Associated with Reduced Atherosclerosis in a Mouse Model of Familial Hypercholesterolemia J. Biol. Chem., September 13, 2002; 277(38): 35350 - 35356. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. A. Butcher and E. Y. Denkers Mechanism of Entry Determines the Ability of Toxoplasma gondii To Inhibit Macrophage Proinflammatory Cytokine Production Infect. Immun., September 1, 2002; 70(9): 5216 - 5224. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Caamano and C. A. Hunter NF-{kappa}B Family of Transcription Factors: Central Regulators of Innate and Adaptive Immune Functions Clin. Microbiol. Rev., July 1, 2002; 15(3): 414 - 429. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. F. Anderson and D. M. Mosser A novel phenotype for an activated macrophage: the type 2 activated macrophage J. Leukoc. Biol., July 1, 2002; 72(1): 101 - 106. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. F. Anderson and D. M. Mosser Cutting Edge: Biasing Immune Responses by Directing Antigen to Macrophage Fc{gamma} Receptors J. Immunol., April 15, 2002; 168(8): 3697 - 3701. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Mason, J. Aliberti, J. C. Caamano, H.-C. Liou, and C. A. Hunter Cutting Edge: Identification of c-Rel-Dependent and -Independent Pathways of IL-12 Production During Infectious and Inflammatory Stimuli J. Immunol., March 15, 2002; 168(6): 2590 - 2594. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Bozza, R. Gaziano, A. Spreca, A. Bacci, C. Montagnoli, P. di Francesco, and L. Romani Dendritic Cells Transport Conidia and Hyphae of Aspergillus fumigatus from the Airways to the Draining Lymph Nodes and Initiate Disparate Th Responses to the Fungus J. Immunol., February 1, 2002; 168(3): 1362 - 1371. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
