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Sections of Infectious Diseases and Immunobiology, Yale School of Medicine, New Haven, CT 06520
Listeria monocytogenes is an intracellular bacterium
that causes systemic infections after traversing the intestinal mucosa.
Clearance of infection and long term protective immunity are mediated
by L. monocytogenes-specific CD8 T lymphocytes. In this
report, we characterize the murine CD8 T cell response in the lamina
propria and intestinal epithelium after enteric L.
monocytogenes infection. We find that the frequency of MHC
class Ia-restricted, L. monocytogenes-specific T cells
is 
4- to 5-fold greater in the lamina propria than in the spleen of
mice after oral or i.v. infection. Although the kinetics of T cell
expansion and contraction are similar in spleen, lamina propria, and
intestinal epithelium, high frequencies of Ag-specific T cells are
detected only in the lamina propria 1 mo after infection. In contrast
to MHC class Ia-restricted T cells, the frequency of H2-M3-restricted,
L. monocytogenes-specific T cells is decreased in the
intestinal mucosa relative to that found in the spleen. In addition to
this disparity, we find that MHC class Ia-restricted CD8 T cells
specific for a dominant L. monocytogenes epitope have
different TCR V
repertoires in the spleen and intestinal mucosa of
individual mice. These findings indicate that the intestinal mucosa is
a depot where L. monocytogenes-specific effector CD8 T
cells accumulate during and after infection irrespective of
immunization route. Furthermore, our results demonstrate that CD8 T
cell populations in these two sites, although overlapping in Ag
specificity, are distinct in terms of their
repertoire.
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