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Division of Immunogenetics, University of Göttingen, Göttingen, Germany
The rat is an important model for studying organ graft rejection
and susceptibility to certain complex diseases. The MHC, the RT1
complex, plays a decisive role in controlling these traits. We have
cloned the telomeric class I region of the RT1 complex, RT1-C/E/M, of
the BN inbred rat strain in a contig of overlapping P1-derived
artificial chromosome clones encompassing 
2 Mb, and present a
physical map of this MHC region. Forty-five class I exon 4-hybridizing
BamHI fragments were detected, including the previously
known rat class I genes RT1-E, RT-BM1, RT1-N, RT1-M2,
RT1-M3, and RT1-M4. Twenty-six non-class I genes
known to map to the corresponding part of the human and mouse MHC were
tested and could be fine mapped in the RT1-C/E/M region at orthologous
position. Four previously known microsatellite markers were fine mapped
in the RT1-C/E/M region and found to occur in multiple copies. In
addition, a new, single-copy polymorphic microsatellite has been
defined. The expression profiles of several class I genes and the 26
non-class I genes were determined in 13 different tissues and exhibited
restricted patterns in most cases. The data provide further molecular
information on the MHC for analyzing disease susceptibility and
underline the usefulness of the rat model.
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