| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
TCR Rearrangement Express Highly Diverse Killer Cell Ig-Like Receptor Patterns1
*
Departments of Structural Biology and Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305; and
DNAX Research Institute for Molecular and Cellular Biology, Palo Alto, CA 94306
Killer cell Ig-like receptor (KIR) and CD94:NKG2A molecules were
first defined as human NK cell receptors (NKR), but now are known to be
expressed and to function on subpopulations of T cells. Here the
repertoires of KIR and CD94:NKG2A expression by T cells from two donors
were examined and compared with their previously defined NK cell
repertoires. T cell clones generated from peripheral blood of both
donors expressed multiple NKR in different combinations and used the
range of receptors expressed by NK cells. In both donors 
T cells
less frequently expressed the inhibitory receptors CD94:NKG2A and
KIR2DL1 than either 
T cells or NK cells. In contrast to NK
cells, not all NKR+ T cells expressed an inhibitory
receptor for autologous HLA class I. This lack of specific inhibitory
NKR was especially apparent on T cells of one donor. Overall,
T cells exhibited a distinct pattern of NKR expression different
from that of T and NK cells, which expressed highly similar NKR
repertoires. In one donor, analysis of TCR rearrangement revealed a
dominant subset of NKR+ T cells sharing identical TCR -
and -chains. Remarkably, among 55 T cell clones sharing the same
TCR rearrangement 18 different KIR phenotypes were seen,
suggesting that KIR expression was initiated subsequently to TCR
rearrangement.
This article has been cited by other articles:
|
|
 |
|
  L. T. van der Veken, M. Diez Campelo, M. A. W. G. van der Hoorn, R. S. Hagedoorn, H. M. E. van Egmond, J. van Bergen, R. Willemze, J. H. F. Falkenburg, and M. H. M. Heemskerk Functional Analysis of Killer Ig-Like Receptor-Expressing Cytomegalovirus-Specific CD8+ T Cells J. Immunol., January 1, 2009; 182(1): 92 - 101. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Iannello, O. Debbeche, S. Samarani, and A. Ahmad Antiviral NK cell responses in HIV infection: II. viral strategies for evasion and lessons for immunotherapy and vaccination J. Leukoc. Biol., July 1, 2008; 84(1): 27 - 49. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. A. Guethlein, A. M. Older Aguilar, L. Abi-Rached, and P. Parham Evolution of Killer Cell Ig-Like Receptor (KIR) Genes: Definition of an Orangutan KIR Haplotype Reveals Expansion of Lineage III KIR Associated with the Emergence of MHC-C J. Immunol., July 1, 2007; 179(1): 491 - 504. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. C. Fischer, H. Ottinger, S. Ferencik, M. Sribar, M. Punzel, D. W. Beelen, M. A. Schwan, H. Grosse-Wilde, P. Wernet, and M. Uhrberg Relevance of C1 and C2 Epitopes for Hemopoietic Stem Cell Transplantation: Role for Sequential Acquisition of HLA-C-Specific Inhibitory Killer Ig-Like Receptor J. Immunol., March 15, 2007; 178(6): 3918 - 3923. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. S. Warren, P. M. Rana, D. T. Rieger, K. A. Hewitt, J. E. Dahlstrom, and A. L. Kent CD8 T cells expressing killer Ig-like receptors and NKG2A are present in cord blood and express a more naive phenotype than their counterparts in adult blood J. Leukoc. Biol., June 1, 2006; 79(6): 1252 - 1259. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Xu, A. N. Vallejo, Y. Jiang, C. M. Weyand, and J. J. Goronzy Distinct Transcriptional Control Mechanisms of Killer Immunoglobulin-like Receptors in Natural Killer (NK) and in T Cells J. Biol. Chem., June 24, 2005; 280(25): 24277 - 24285. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-I. Trompeter, N. Gomez-Lozano, S. Santourlidis, B. Eisermann, P. Wernet, C. Vilches, and M. Uhrberg Three Structurally and Functionally Divergent Kinds of Promoters Regulate Expression of Clonally Distributed Killer Cell Ig-Like Receptors (KIR), of KIR2DL4, and of KIR3DL3 J. Immunol., April 1, 2005; 174(7): 4135 - 4143. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Anfossi, J.-M. Doisne, M.-A. Peyrat, S. Ugolini, O. Bonnaud, D. Bossy, V. Pitard, P. Merville, J.-F. Moreau, J.-F. Delfraissy, et al. Coordinated Expression of Ig-Like Inhibitory MHC Class I Receptors and Acquisition of Cytotoxic Function in Human CD8+ T Cells J. Immunol., December 15, 2004; 173(12): 7223 - 7229. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. van Bergen, A. Thompson, A. van der Slik, T. H. M. Ottenhoff, J. Gussekloo, and F. Koning Phenotypic and Functional Characterization of CD4 T Cells Expressing Killer Ig-Like Receptors J. Immunol., December 1, 2004; 173(11): 6719 - 6726. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Ikehara, S. K. Ikehara, and J. C. Paulson Negative Regulation of T Cell Receptor Signaling by Siglec-7 (p70/AIRM) and Siglec-9 J. Biol. Chem., October 8, 2004; 279(41): 43117 - 43125. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. R. Snyder, T. Nakajima, P. J. Leibson, C. M. Weyand, and J. J. Goronzy Stimulatory Killer Ig-Like Receptors Modulate T Cell Activation through DAP12-Dependent and DAP12-Independent Mechanisms J. Immunol., September 15, 2004; 173(6): 3725 - 3731. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. K. Epling-Burnette, J. S. Painter, P. Chaurasia, F. Bai, S. Wei, J. Y. Djeu, and T. P. Loughran Jr Dysregulated NK receptor expression in patients with lymphoproliferative disease of granular lymphocytes Blood, May 1, 2004; 103(9): 3431 - 3439. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. U. Saikh, B. Dyas, T. Kissner, and R. G. Ulrich CD56+-T-Cell Responses to Bacterial Superantigens and Immune Recognition of Attenuated Vaccines Clin. Vaccine Immunol., November 1, 2003; 10(6): 1065 - 1073. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. R. van der Slik, B. P.C. Koeleman, W. Verduijn, G. J. Bruining, B. O. Roep, and M. J. Giphart KIR in Type 1 Diabetes: Disparate Distribution of Activating and Inhibitory Natural Killer Cell Receptors in Patients Versus HLA-Matched Control Subjects Diabetes, October 1, 2003; 52(10): 2639 - 2642. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. A. Stewart, J. van Bergen, and J. Trowsdale Different and Divergent Regulation of the KIR2DL4 and KIR3DL1 Promoters J. Immunol., June 15, 2003; 170(12): 6073 - 6081. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. R. Snyder, M. Lucas, E. Vivier, C. M. Weyand, and J. J. Goronzy Selective Activation of the c-Jun NH2-terminal Protein Kinase Signaling Pathway by Stimulatory KIR in the Absence of KARAP/DAP12 in CD4+ T Cells J. Exp. Med., February 17, 2003; 197(4): 437 - 449. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Hummel, D. Wilms, M. Vitacolonna, and M. Zoller Donor T cell and host NK depletion improve the therapeutic efficacy of allogeneic bone marrow cell reconstitution in the nonmyeloablatively conditioned tumor-bearing host J. Leukoc. Biol., November 1, 2002; 72(5): 898 - 912. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. C. Hsu, X.-R. Liu, A. Selvakumar, E. Mickelson, R. J. O'Reilly, and B. Dupont Killer Ig-Like Receptor Haplotype Analysis by Gene Content: Evidence for Genomic Diversity with a Minimum of Six Basic Framework Haplotypes, Each with Multiple Subsets J. Immunol., November 1, 2002; 169(9): 5118 - 5129. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Santourlidis, H.-I. Trompeter, S. Weinhold, B. Eisermann, K. L. Meyer, P. Wernet, and M. Uhrberg Crucial Role of DNA Methylation in Determination of Clonally Distributed Killer Cell Ig-like Receptor Expression Patterns in NK Cells J. Immunol., October 15, 2002; 169(8): 4253 - 4261. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.-J. Chwae, M. J. Chang, S. M. Park, H. Yoon, H.-J. Park, S. J. Kim, and J. Kim Molecular Mechanism of the Activation-Induced Cell Death Inhibition Mediated by a p70 Inhibitory Killer Cell Ig-Like Receptor in Jurkat T Cells J. Immunol., October 1, 2002; 169(7): 3726 - 3735. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Dulphy, C. Rabian, C. Douay, O. Flinois, S. Laoussadi, J. Kuipers, R. Tamouza, D. Charron, and A. Toubert Functional modulation of expanded CD8+ synovial fluid T cells by NK cell receptor expression in HLA-B27-associated reactive arthritis Int. Immunol., May 1, 2002; 14(5): 471 - 479. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. R. Snyder, L.-O. Muegge, C. Offord, W. M. O'Fallon, Z. Bajzer, C. M. Weyand, and J. J. Goronzy Formation of the Killer Ig-Like Receptor Repertoire on CD4+CD28null T Cells J. Immunol., April 15, 2002; 168(8): 3839 - 3846. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Y. Djeu, K. Jiang, and S. Wei A View to a Kill: Signals Triggering Cytotoxicity Clin. Cancer Res., March 1, 2002; 8(3): 636 - 640. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. G. Shilling, L. A. Guethlein, N. W. Cheng, C. M. Gardiner, R. Rodriguez, D. Tyan, and P. Parham Allelic Polymorphism Synergizes with Variable Gene Content to Individualize Human KIR Genotype J. Immunol., March 1, 2002; 168(5): 2307 - 2315. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Canavez, N. T. Young, L. A. Guethlein, R. Rajalingam, S. I. Khakoo, B. P. Shum, and P. Parham Comparison of Chimpanzee and Human Leukocyte Ig-Like Receptor Genes Reveals Framework and Rapidly Evolving Genes J. Immunol., November 15, 2001; 167(10): 5786 - 5794. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. T. Young, M. Uhrberg, J. H. Phillips, L. L. Lanier, and P. Parham Differential Expression of Leukocyte Receptor Complex-Encoded Ig-Like Receptors Correlates with the Transition from Effector to Memory CTL J. Immunol., March 15, 2001; 166(6): 3933 - 3941. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
