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RIIb21
Departments of
*
Internal Medicine and
Physiology and Cell Biology, Ohio State University, Columbus, OH 43210;
Institut Curie, Paris, France; and
University of Bielefeld, Bielefeld, Germany
To evaluate the potential role of human placental endothelial cells
in the transport of IgG from maternal to fetal circulation, we studied
Fc
receptor (FcR) expression by immunohistology and
immunoblotting. Several pan-FcRII Abs that label the placental
endothelium displayed a distribution pattern that correlated well with
transport functions, being intense in the terminal villus and nil in
the cord. In contrast, the MHC class 1-like IgG transporter, FcRn, and
the classical FcRIIa were not expressed in transport-related
endothelium of the placenta. Our inference, that FcRIIb was the
likely receptor, we confirmed by analyzing purified placental villi,
enriched in endothelium, by immunoblotting with a new Ab specific for
the cytoplasmic tail of FcRIIb. These experiments showed that the
FcRII expressed in villus endothelium was the b2 isoform whose
cytoplasmic tail is known to include a phosphotyrosyl-based motif that
inhibits a variety of immune responses. We suggest that this receptor
is perfectly positioned to transport IgG although as well it may
scavenge immune complexes.
This article has been cited by other articles:
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  T. Takizawa, C. L. Anderson, and J. M. Robinson A Novel Fc{gamma}R-Defined, IgG-Containing Organelle in Placental Endothelium J. Immunol., August 15, 2005; 175(4): 2331 - 2339. [Abstract] [Full Text] [PDF]
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 Y. Liu, E. Masuda, M. C. Blank, K. A. Kirou, X. Gao, M.-S. Park, and L. Pricop Cytokine-mediated regulation of activating and inhibitory Fc{gamma} receptors in human monocytes J. Leukoc. Biol., May 1, 2005; 77(5): 767 - 776. [Abstract] [Full Text] [PDF]
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 C. L. Kepley, S. Taghavi, G. Mackay, D. Zhu, P. A. Morel, K. Zhang, J. J. Ryan, L. S. Satin, M. Zhang, P. P. Pandolfi, et al. Co-aggregation of Fc{gamma}RII with Fc{epsilon}RI on Human Mast Cells Inhibits Antigen-induced Secretion and Involves SHIP-Grb2-Dok Complexes J. Biol. Chem., August 20, 2004; 279(34): 35139 - 35149. [Abstract] [Full Text] [PDF]
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S. Tridandapani, R. Wardrop, C. P. Baran, Y. Wang, J. M. Opalek, M. A. Caligiuri, and C. B. Marsh TGF-{beta}1 Suppresses Myeloid Fc{gamma} Receptor Function by Regulating the Expression and Function of the Common {gamma}-Subunit J. Immunol., May 1, 2003; 170(9): 4572 - 4577. [Abstract] [Full Text] [PDF]
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 M. G. Kolonin, R. Pasqualini, and W. Arap Teratogenicity induced by targeting a placental immunoglobulin transporter PNAS, October 1, 2002; 99(20): 13055 - 13060. [Abstract] [Full Text] [PDF]
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S. Tridandapani, K. Siefker, J.-L. Teillaud, J. E. Carter, M. D. Wewers, and C. L. Anderson Regulated Expression and Inhibitory Function of Fcgamma RIIb in Human Monocytic Cells J. Biol. Chem., February 8, 2002; 277(7): 5082 - 5089. [Abstract] [Full Text] [PDF]
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