HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Trobonjaca, Z. Articles by Reimann, J. Search for Related Content PubMed PubMed Citation Articles by Trobonjaca, Z. Articles by Reimann, J.

MHC-II-Independent CD4⁺ T Cells Induce Colitis in Immunodeficient RAG^-/- Hosts¹

Zlatko Trobonjaca^*, Frank Leithäuser, Peter Möller, Horst Bluethmann, Yasuhiko Koezuka, H. Robson MacDonald^¶ and Jörg Reimann^2,*

Departments of ^* Medical Microbiology and Immunology and Pathology, University of Ulm, Ulm, Germany; Roche Genetics, F. Hoffmann LaRoche, Basel, Switzerland; Kirin Brewery, Pharmaceutical Research Laboratory, Gunma, Japan; and ^¶ Ludwig Institute for Cancer Research, Epalinges, Switzerland

CD4⁺ T cells from either normal C57BL/6 (B6) or MHC-II-deficient (A^-/- or A^-/-) B6 donor mice engrafted into congenic immunodeficient RAG1^-/- B6 hosts induced an aggressive inflammatory bowel disease (IBD). Furthermore, CD4⁺ T cells from CD1d^-/- knockout (KO) B6 donor mice but not those from MHC-I^-/- (homozygous transgenic mice deficient for ₂-microglobulin) KO B6 mice induced a colitis in RAG^-/- hosts. Abundant numbers of in vivo activated (CD69^highCD44^highCD28^high) NK1⁺ and NK1^- CD4⁺ T cells were isolated from the inflamed colonic lamina propria (cLP) of transplanted mice with IBD that produced large amounts of TNF- and IFN- but low amounts of IL-4 and IL-10. IBD-associated cLP Th1 CD4⁺ T cell populations were polyclonal and MHC-II-restricted when derived from normal B6 donor mice, but oligoclonal and apparently MHC-I-restricted when derived from MHC-II-deficient (A^-/- or A^-/-) B6 donor mice. cLP CD4⁺ T cell populations from homozygous transgenic mice deficient for ₂-microglobulin KO B6 donor mice engrafted into RAG^-/- hosts were Th2 and MHC-II restricted. These data indicate that MHC-II-dependent as well as MHC-II-independent CD4⁺ T cells can induce a severe and lethal IBD in congenic, immunodeficient hosts, but that the former need the latter to express its IBD-inducing potential.

This article has been cited by other articles:

				P. Bochtler, C. Wahl, R. Schirmbeck, and J. Reimann Functional Adaptive CD4 Foxp3 T Cells Develop in MHC Class II-Deficient Mice J. Immunol., December 15, 2006; 177(12): 8307 - 8314. [Abstract] [Full Text] [PDF]

				B. Bienvenu, B. Martin, C. Auffray, C. Cordier, C. Becourt, and B. Lucas Peripheral CD8+CD25+ T Lymphocytes from MHC Class II-Deficient Mice Exhibit Regulatory Activity J. Immunol., July 1, 2005; 175(1): 246 - 253. [Abstract] [Full Text] [PDF]

				K. Takeshita, T. Yamasaki, S. Akira, F. Gantner, and K. B. Bacon Essential role of MHC II-independent CD4+ T cells, IL-4 and STAT6 in contact hypersensitivity induced by fluorescein isothiocyanate in the mouse Int. Immunol., May 1, 2004; 16(5): 685 - 695. [Abstract] [Full Text] [PDF]

				L. H. Boyle and J. S. Hill Gaston Breaking the rules: the unconventional recognition of HLA-B27 by CD4+ T lymphocytes as an insight into the pathogenesis of the spondyloarthropathies Rheumatology, March 1, 2003; 42(3): 404 - 412. [Abstract] [Full Text] [PDF]

				M. J. Pinkoski, N. M. Droin, and D. R. Green Tumor Necrosis Factor alpha Up-regulates Non-lymphoid Fas-ligand following Superantigen-induced Peripheral Lymphocyte Activation J. Biol. Chem., October 25, 2002; 277(44): 42380 - 42385. [Abstract] [Full Text] [PDF]

				L. H. Boyle, J. C. Goodall, S. S. Opat, and J. S. H. Gaston The Recognition of HLA-B27 by Human CD4+ T Lymphocytes J. Immunol., September 1, 2001; 167(5): 2619 - 2624. [Abstract] [Full Text] [PDF]