The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hara, M.
Right arrow Articles by Wood, K. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hara, M.
Right arrow Articles by Wood, K. J.
The Journal of Immunology, 2001, 166: 3789-3796.
Copyright © 2001 by The American Association of Immunologists

IL-10 Is Required for Regulatory T Cells to Mediate Tolerance to Alloantigens In Vivo1

Masaki Hara, Cherry I. Kingsley, Masanori Niimi, Simon Read, Stuart E. Turvey, Andrew R. Bushell, Peter J. Morris, Fiona Powrie and Kathryn J. Wood2

Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom

We present evidence that donor-reactive CD4+ T cells present in mice tolerant to donor alloantigens are phenotypically and functionally heterogeneous. CD4+ T cells contained within the CD45RBhigh fraction remained capable of mediating graft rejection when transferred to donor alloantigen-grafted T cell-depleted mice. In contrast, the CD45RBlow CD4+ and CD25+CD4+ populations failed to induce rejection, but rather, were able to inhibit rejection initiated by naive CD45RBhigh CD4+ T cells. Analysis of the mechanism of immunoregulation transferred by CD45RBlow CD4+ T cells in vivo revealed that it was donor Ag specific and could be inhibited by neutralizing Abs reactive with IL-10, but not IL-4. CD45RBlow CD4+ T cells from tolerant mice were also immune suppressive in vitro, as coculture of these cells with naive CD45RBhigh CD4+ T cells inhibited proliferation and Th1 cytokine production in response to donor alloantigens presented via the indirect pathway. These results demonstrate that alloantigen-specific regulatory T cells contained within the CD45RBlow CD4+ T cell population are responsible for the maintenance of tolerance to donor alloantigens in vivo and require IL-10 for functional activity.




This article has been cited by other articles:


Home page
 BloodHome page
M. Nikolova, J.-D. Lelievre, M. Carriere, A. Bensussan, and Y. Levy
Regulatory T cells differentially modulate the maturation and apoptosis of human CD8+ T-cell subsets
Blood, May 7, 2009; 113(19): 4556 - 4565.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. Schumacher, N. Brachwitz, S. Sohr, K. Engeland, S. Langwisch, M. Dolaptchieva, T. Alexander, A. Taran, S. F. Malfertheiner, S.-D. Costa, et al.
Human Chorionic Gonadotropin Attracts Regulatory T Cells into the Fetal-Maternal Interface during Early Human Pregnancy
J. Immunol., May 1, 2009; 182(9): 5488 - 5497.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
S. H. Wang, G.-H. Chen, Y. Fan, M. Van Antwerp, and J. R. Baker Jr.
Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Inhibits Experimental Autoimmune Thyroiditis by the Expansion of CD4+CD25+ Regulatory T Cells
Endocrinology, April 1, 2009; 150(4): 2000 - 2007.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
K. Nagahama, Z. Fehervari, T. Oida, T. Yamaguchi, O. Ogawa, and S. Sakaguchi
Differential control of allo-antigen-specific regulatory T cells and effector T cells by anti-CD4 and other agents in establishing transplantation tolerance
Int. Immunol., April 1, 2009; 21(4): 379 - 391.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
A. M. Waaga-Gasser, M. R. Grimm, J. Lutz, V. Lange, S. M. Lenhard, B. Aviles, J. E. Kist-van Holthe, T. Lebedeva, D. Samsonov, D. Meyer, et al.
Regulatory Allospecific T Cell Clones Abrogate Chronic Allograft Rejection
J. Am. Soc. Nephrol., April 1, 2009; 20(4): 820 - 830.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
H. Zhang, J. R. Podojil, X. Luo, and S. D. Miller
Intrinsic and Induced Regulation of the Age-Associated Onset of Spontaneous Experimental Autoimmune Encephalomyelitis
J. Immunol., October 1, 2008; 181(7): 4638 - 4647.
[Abstract] [Full Text] [PDF]

Home page
 Ann Rheum DisHome page
F Forger, N Marcoli, S Gadola, B Moller, P M Villiger, and M Ostensen
Pregnancy induces numerical and functional changes of CD4+CD25high regulatory T cells in patients with rheumatoid arthritis
Ann Rheum Dis, July 1, 2008; 67(7): 984 - 990.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. Carvalho-Gaspar, N. D. Jones, S. Luo, L. Martin, M. O. Brook, and K. J. Wood
Location and Time-Dependent Control of Rejection by Regulatory T Cells Culminates in a Failure to Generate Memory T Cells
J. Immunol., May 15, 2008; 180(10): 6640 - 6648.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
A. Giorgini and A. Noble
Blockade of chronic graft-versus-host disease by alloantigen-induced CD4+CD25+Foxp3+ regulatory T cells in nonlymphopenic hosts
J. Leukoc. Biol., November 1, 2007; 82(5): 1053 - 1061.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
S. S. Lee, W. Gao, S. Mazzola, M. N. Thomas, E. Csizmadia, L. E Otterbein, F. H. Bach, and H. Wang
Heme oxygenase-1, carbon monoxide, and bilirubin induce tolerance in recipients toward islet allografts by modulating T regulatory cells
FASEB J, November 1, 2007; 21(13): 3450 - 3457.
[Abstract] [Full Text] [PDF]

Home page
 J BiochemHome page
S. Hu, J. Dai, H. Wei, K. Fan, H. Wang, D. Zhang, W. Qian, B. Li, H. Wang, T. Zhu, et al.
Functional and Stable Expression of Recombinant Human FOXP3 in Bacterial Cells and Development of Antigen-specific Monoclonal Antibodies
J. Biochem., October 1, 2007; 142(4): 471 - 480.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
A. Joetham, K. Takeda, N. Miyahara, S. Matsubara, H. Ohnishi, T. Koya, A. Dakhama, and E. W. Gelfand
Activation of naturally occurring lung CD4+CD25+ regulatory T cells requires CD8 and MHC I interaction
PNAS, September 18, 2007; 104(38): 15057 - 15062.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
K. N. Taylor, V. R. Shinde-Patil, E. Cohick, and Y. L. Colson
Induction of FoxP3+CD4+25+ Regulatory T Cells Following Hemopoietic Stem Cell Transplantation: Role of Bone Marrow-Derived Facilitating Cells
J. Immunol., August 15, 2007; 179(4): 2153 - 2162.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. Dong, C. Ivascu, H.-D. Chang, P. Wu, R. Angeli, L. Maggi, F. Eckhardt, L. Tykocinski, C. Haefliger, B. Mowes, et al.
IL-10 Is Excluded from the Functional Cytokine Memory of Human CD4+ Memory T Lymphocytes
J. Immunol., August 15, 2007; 179(4): 2389 - 2396.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
C. Schmidt-Lucke, A. Aicher, P. Romagnani, B. Gareis, S. Romagnani, A. M. Zeiher, and S. Dimmeler
Specific recruitment of CD4+CD25++ regulatory T cells into the allograft in heart transplant recipients
Am J Physiol Heart Circ Physiol, May 1, 2007; 292(5): H2425 - H2431.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
Q. Xu, J. Lee, E. Jankowska-Gan, J. Schultz, D. A. Roennburg, L. D. Haynes, S. Kusaka, H. W. Sollinger, S. J. Knechtle, A. M. VanBuskirk, et al.
Human CD4+CD25low Adaptive T Regulatory Cells Suppress Delayed-Type Hypersensitivity during Transplant Tolerance
J. Immunol., March 15, 2007; 178(6): 3983 - 3995.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C. J. Callaghan, F. J. Rouhani, M. C. Negus, A. J. Curry, E. M. Bolton, J. A. Bradley, and G. J. Pettigrew
Abrogation of Antibody-Mediated Allograft Rejection by Regulatory CD4 T Cells with Indirect Allospecificity
J. Immunol., February 15, 2007; 178(4): 2221 - 2228.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
D. Golshayan, S. Jiang, J. Tsang, M. I. Garin, C. Mottet, and R. I. Lechler
In vitro-expanded donor alloantigen-specific CD4+CD25+ regulatory T cells promote experimental transplantation tolerance
Blood, January 15, 2007; 109(2): 827 - 835.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
M. Lopez, M. R. Clarkson, M. Albin, M. H. Sayegh, and N. Najafian
A Novel Mechanism of Action for Anti-Thymocyte Globulin: Induction of CD4+CD25+Foxp3+ Regulatory T Cells
J. Am. Soc. Nephrol., October 1, 2006; 17(10): 2844 - 2853.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
T. Mutis, R. S. van Rijn, E. R. Simonetti, T. Aarts-Riemens, M. E. Emmelot, L. van Bloois, A. Martens, L. F. Verdonck, and S. B. Ebeling
Human Regulatory T Cells Control Xenogeneic Graft-versus-Host Disease Induced by Autologous T Cells in RAG2-/-{gamma}c-/- Immunodeficient Mice.
Clin. Cancer Res., September 15, 2006; 12(18): 5520 - 5525.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
Q. Wang, Y. Liu, J. Wang, G. Ding, W. Zhang, G. Chen, M. Zhang, S. Zheng, and X. Cao
Induction of Allospecific Tolerance by Immature Dendritic Cells Genetically Modified to Express Soluble TNF Receptor
J. Immunol., August 15, 2006; 177(4): 2175 - 2185.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
M. Beyer and J. L. Schultze
Regulatory T cells in cancer
Blood, August 1, 2006; 108(3): 804 - 811.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
K. S. Nicolson, E. J. O'Neill, A. Sundstedt, H. B. Streeter, S. Minaee, and D. C. Wraith
Antigen-Induced IL-10+ Regulatory T Cells Are Independent of CD25+ Regulatory Cells for Their Growth, Differentiation, and Function
J. Immunol., May 1, 2006; 176(9): 5329 - 5337.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
H. Keino, M. Takeuchi, T. Kezuka, T. Hattori, M. Usui, O. Taguchi, J. W. Streilein, and J. Stein-Streilein
Induction of Eye-Derived Tolerance Does Not Depend on Naturally Occurring CD4+CD25+ T Regulatory Cells.
Invest. Ophthalmol. Vis. Sci., March 1, 2006; 47(3): 1047 - 1055.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
K. Rieger, C. Loddenkemper, J. Maul, T. Fietz, D. Wolff, H. Terpe, B. Steiner, E. Berg, S. Miehlke, M. Bornhauser, et al.
Mucosal FOXP3+ regulatory T cells are numerically deficient in acute and chronic GvHD
Blood, February 15, 2006; 107(4): 1717 - 1723.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
J. J. A. Coenen, H. J. P. M. Koenen, E. van Rijssen, L. B. Hilbrands, and I. Joosten
Rapamycin, and not cyclosporin A, preserves the highly suppressive CD27+ subset of human CD4+CD25+ regulatory T cells
Blood, February 1, 2006; 107(3): 1018 - 1023.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. Trenado, M. Sudres, Q. Tang, S. Maury, F. Charlotte, S. Gregoire, M. Bonyhadi, D. Klatzmann, B. L. Salomon, and J. L. Cohen
Ex Vivo-Expanded CD4+CD25+ Immunoregulatory T Cells Prevent Graft-versus-Host-Disease by Inhibiting Activation/Differentiation of Pathogenic T Cells
J. Immunol., January 15, 2006; 176(2): 1266 - 1273.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. Sanchez-Fueyo, S. Sandner, A. Habicht, C. Mariat, J. Kenny, N. Degauque, X. X. Zheng, T. B. Strom, L. A. Turka, and M. H. Sayegh
Specificity of CD4+CD25+ Regulatory T Cell Function in Alloimmunity
J. Immunol., January 1, 2006; 176(1): 329 - 334.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C. K. Asiedu, K. J. Goodwin, G. Balgansuren, S. M. Jenkins, S. Le Bas-Bernardet, U. Jargal, D. M. Neville Jr, and J. M. Thomas
Elevated T Regulatory Cells in Long-Term Stable Transplant Tolerance in Rhesus Macaques Induced by Anti-CD3 Immunotoxin and Deoxyspergualin
J. Immunol., December 15, 2005; 175(12): 8060 - 8068.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. T. Endharti, M. Rifa' I, Z. Shi, Y. Fukuoka, Y. Nakahara, Y. Kawamoto, K. Takeda, K.-i. Isobe, and H. Suzuki
Cutting Edge: CD8+CD122+ Regulatory T Cells Produce IL-10 to Suppress IFN-{gamma} Production and Proliferation of CD8+ T Cells
J. Immunol., December 1, 2005; 175(11): 7093 - 7097.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
C. A. Wysocki, Q. Jiang, A. Panoskaltsis-Mortari, P. A. Taylor, K. P. McKinnon, L. Su, B. R. Blazar, and J. S. Serody
Critical role for CCR5 in the function of donor CD4+CD25+ regulatory T cells during acute graft-versus-host disease
Blood, November 1, 2005; 106(9): 3300 - 3307.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
H. Kitade, M. Kawai, O. Rutgeerts, W. Landuyt, M. Waer, C. Mathieu, and J. Pirenne
Early Presence of Regulatory Cells in Transplanted Rats Rendered Tolerant by Donor-Specific Blood Transfusion
J. Immunol., October 15, 2005; 175(8): 4963 - 4970.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
T. Yokoyama, O. Aramaki, T. Takayama, S. Takano, Q. Zhang, M. Shimazu, M. Kitajima, Y. Ikeda, N. Shirasugi, and M. Niimi
Selective cyclooxygenase 2 inhibitor induces indefinite survival of fully allogeneic cardiac grafts and generates CD4+ regulatory cells
J. Thorac. Cardiovasc. Surg., October 1, 2005; 130(4): 1167 - 1174.
[Abstract] [Full Text] [PDF]

Home page
 Phil Trans R Soc BHome page
Z. Fehervari and S. Sakaguchi
CD4+ regulatory cells as a potential immunotherapy
Phil Trans R Soc B, September 29, 2005; 360(1461): 1647 - 1661.
[Abstract] [Full Text] [PDF]

Home page
 Phil Trans R Soc BHome page
S. P Hickman and L. A Turka
Homeostatic T cell proliferation as a barrier to T cell tolerance
Phil Trans R Soc B, September 29, 2005; 360(1461): 1713 - 1721.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. A. Quezada, K. Bennett, B. R. Blazar, A. Y. Rudensky, S. Sakaguchi, and R. J. Noelle
Analysis of the Underlying Cellular Mechanisms of Anti-CD154-Induced Graft Tolerance: The Interplay of Clonal Anergy and Immune Regulation
J. Immunol., July 15, 2005; 175(2): 771 - 779.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C. Domenig, A. Sanchez-Fueyo, J. Kurtz, S. P. Alexopoulos, C. Mariat, M. Sykes, T. B. Strom, and X. X. Zheng
Roles of Deletion and Regulation in Creating Mixed Chimerism and Allograft Tolerance Using a Nonlymphoablative Irradiation-Free Protocol
J. Immunol., July 1, 2005; 175(1): 51 - 60.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
B. Sawitzki, C. I. Kingsley, V. Oliveira, M. Karim, M. Herber, and K. J. Wood
IFN-{gamma} production by alloantigen-reactive regulatory T cells is important for their regulatory function in vivo
J. Exp. Med., June 20, 2005; 201(12): 1925 - 1935.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
H. J. P. M. Koenen, E. Fasse, and I. Joosten
CD27/CFSE-Based Ex Vivo Selection of Highly Suppressive Alloantigen-Specific Human Regulatory T Cells
J. Immunol., June 15, 2005; 174(12): 7573 - 7583.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
L. Myers, M. Croft, B. S. Kwon, R. S. Mittler, and A. T. Vella
Peptide-Specific CD8 T Regulatory Cells Use IFN-{gamma} to Elaborate TGF-{beta}-Based Suppression
J. Immunol., June 15, 2005; 174(12): 7625 - 7632.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
M. Karim, G. Feng, K. J. Wood, and A. R. Bushell
CD25+CD4+ regulatory T cells generated by exposure to a model protein antigen prevent allograft rejection: antigen-specific reactivation in vivo is critical for bystander regulation
Blood, June 15, 2005; 105(12): 4871 - 4877.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
E. Gangi, C. Vasu, D. Cheatem, and B. S. Prabhakar
IL-10-Producing CD4+CD25+ Regulatory T Cells Play a Critical Role in Granulocyte-Macrophage Colony-Stimulating Factor-Induced Suppression of Experimental Autoimmune Thyroiditis
J. Immunol., June 1, 2005; 174(11): 7006 - 7013.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
I. W. Nasr, Y. Wang, G. Gao, S. Deng, L. Diggs, D. M. Rothstein, G. Tellides, F. G. Lakkis, and Z. Dai
Testicular Immune Privilege Promotes Transplantation Tolerance by Altering the Balance between Memory and Regulatory T Cells
J. Immunol., May 15, 2005; 174(10): 6161 - 6168.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. S. Kang and P. M. Allen
Priming in the Presence of IL-10 Results in Direct Enhancement of CD8+ T Cell Primary Responses and Inhibition of Secondary Responses
J. Immunol., May 1, 2005; 174(9): 5382 - 5389.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. Bushell, E. Jones, A. Gallimore, and K. Wood
The Generation of CD25+CD4+ Regulatory T Cells That Prevent Allograft Rejection Does Not Compromise Immunity to a Viral Pathogen
J. Immunol., March 15, 2005; 174(6): 3290 - 3297.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
A. C. Zenclussen, K. Gerlof, M. L. Zenclussen, A. Sollwedel, A. Z. Bertoja, T. Ritter, K. Kotsch, J. Leber, and H.-D. Volk
Abnormal T-Cell Reactivity against Paternal Antigens in Spontaneous Abortion: Adoptive Transfer of Pregnancy-Induced CD4+CD25+ T Regulatory Cells Prevents Fetal Rejection in a Murine Abortion Model
Am. J. Pathol., March 1, 2005; 166(3): 811 - 822.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
A. M. Hanash and R. B. Levy
Donor CD4+CD25+ T cells promote engraftment and tolerance following MHC-mismatched hematopoietic cell transplantation
Blood, February 15, 2005; 105(4): 1828 - 1836.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
P. A. Taylor, A. Panoskaltsis-Mortari, J. M. Swedin, P. J. Lucas, R. E. Gress, B. L. Levine, C. H. June, J. S. Serody, and B. R. Blazar
L-Selectinhi but not the L-selectinlo CD4+25+ T-regulatory cells are potent inhibitors of GVHD and BM graft rejection
Blood, December 1, 2004; 104(12): 3804 - 3812.
[Abstract] [Full Text] [PDF]

Home page
 CVIHome page
D. T. Nardelli, M. A. Burchill, D. M. England, J. Torrealba, S. M. Callister, and R. F. Schell
Association of CD4+ CD25+ T Cells with Prevention of Severe Destructive Arthritis in Borrelia burgdorferi-Vaccinated and Challenged Gamma Interferon-Deficient Mice Treated with Anti-Interleukin-17 Antibody
Clin. Vaccine Immunol., November 1, 2004; 11(6): 1075 - 1084.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. Machen, J. Harnaha, R. Lakomy, A. Styche, M. Trucco, and N. Giannoukakis
Antisense Oligonucleotides Down-Regulating Costimulation Confer Diabetes-Preventive Properties to Nonobese Diabetic Mouse Dendritic Cells
J. Immunol., October 1, 2004; 173(7): 4331 - 4341.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
K. Yamaura, K.-i. Ito, K. Tsukioka, Y. Wada, A. Makiuchi, M. Sakaguchi, T. Akashima, M. Fujimori, Y. Sawa, R. Morishita, et al.
Suppression of Acute and Chronic Rejection by Hepatocyte Growth Factor in a Murine Model of Cardiac Transplantation: Induction of Tolerance and Prevention of Cardiac Allograft Vasculopathy
Circulation, September 21, 2004; 110(12): 1650 - 1657.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
F. Burke, A. J. Stagg, P. A. Bedford, N. English, and S. C. Knight
IL-10-Producing B220+CD11c- APC in Mouse Spleen
J. Immunol., August 15, 2004; 173(4): 2362 - 2372.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C. Vasu, B. S. Prabhakar, and M. J. Holterman
Targeted CTLA-4 Engagement Induces CD4+CD25+CTLA-4high T Regulatory Cells with Target (Allo)antigen Specificity
J. Immunol., August 15, 2004; 173(4): 2866 - 2876.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
E. Nishimura, T. Sakihama, R. Setoguchi, K. Tanaka, and S. Sakaguchi
Induction of antigen-specific immunologic tolerance by in vivo and in vitro antigen-specific expansion of naturally arising Foxp3+CD25+CD4+ regulatory T cells
Int. Immunol., August 1, 2004; 16(8): 1189 - 1201.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
D. P. Beiting, S. K. Bliss, D. H. Schlafer, V. L. Roberts, and J. A. Appleton
Interleukin-10 Limits Local and Body Cavity Inflammation during Infection with Muscle-Stage Trichinella spiralis
Infect. Immun., June 1, 2004; 72(6): 3129 - 3137.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
T. L. Sumpter and D. S. Wilkes
Role of autoimmunity in organ allograft rejection: a focus on immunity to type V collagen in the pathogenesis of lung transplant rejection
Am J Physiol Lung Cell Mol Physiol, June 1, 2004; 286(6): L1129 - L1139.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. K. Lee IV, D. J. Moore, B. P. Jarrett, M. M. Lian, S. Deng, X. Huang, J. W. Markmann, M. Chiaccio, C. F. Barker, A. J. Caton, et al.
Promotion of Allograft Survival by CD4+CD25+ Regulatory T Cells: Evidence for In Vivo Inhibition of Effector Cell Proliferation
J. Immunol., June 1, 2004; 172(11): 6539 - 6544.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
O. Joffre, N. Gorsse, P. Romagnoli, D. Hudrisier, and J. P. M. van Meerwijk
Induction of antigen-specific tolerance to bone marrow allografts with CD4+CD25+ T lymphocytes
Blood, June 1, 2004; 103(11): 4216 - 4221.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
J. Kurtz, J. Shaffer, A. Lie, N. Anosova, G. Benichou, and M. Sykes
Mechanisms of early peripheral CD4 T-cell tolerance induction by anti-CD154 monoclonal antibody and allogeneic bone marrow transplantation: evidence for anergy and deletion but not regulatory cells
Blood, June 1, 2004; 103(11): 4336 - 4343.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
T.-C. Chen, S. P. Cobbold, P. J. Fairchild, and H. Waldmann
Generation of Anergic and Regulatory T Cells following Prolonged Exposure to a Harmless Antigen
J. Immunol., May 15, 2004; 172(10): 5900 - 5907.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
P. L. Vieira, J. R. Christensen, S. Minaee, E. J. O'Neill, F. J. Barrat, A. Boonstra, T. Barthlott, B. Stockinger, D. C. Wraith, and A. O'Garra
IL-10-Secreting Regulatory T Cells Do Not Express Foxp3 but Have Comparable Regulatory Function to Naturally Occurring CD4+CD25+ Regulatory T Cells
J. Immunol., May 15, 2004; 172(10): 5986 - 5993.
[Abstract] [Full Text] [PDF]

Home page
 CVIHome page
L. Aurelian
Herpes Simplex Virus Type 2 Vaccines: New Ground for Optimism?
Clin. Vaccine Immunol., May 1, 2004; 11(3): 437 - 445.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
B. K. Choi, J. S. Bae, E. M. Choi, W. J. Kang, S. Sakaguchi, D. S. Vinay, and B. S. Kwon
4-1BB-dependent inhibition of immunosuppression by activated CD4+CD25+ T cells
J. Leukoc. Biol., May 1, 2004; 75(5): 785 - 791.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. R. Torrealba, M. Katayama, J. H. Fechner Jr., E. Jankowska-Gan, S. Kusaka, Q. Xu, J. M. Schultz, T. D. Oberley, H. Hu, M. M. Hamawy, et al.
Metastable Tolerance to Rhesus Monkey Renal Transplants Is Correlated with Allograft TGF-{beta}1+CD4+ T Regulatory Cell Infiltrates
J. Immunol., May 1, 2004; 172(9): 5753 - 5764.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
E. S. Morris, K. P. A. MacDonald, V. Rowe, D. H. Johnson, T. Banovic, A. D. Clouston, and G. R. Hill
Donor treatment with pegylated G-CSF augments the generation of IL-10-producing regulatory T cells and promotes transplantation tolerance
Blood, May 1, 2004; 103(9): 3573 - 3581.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
J. Cai, J. Lee, E. Jankowska-Gan, R. Derks, J. Pool, T. Mutis, E. Goulmy, and W. J. Burlingham
Minor H Antigen HA-1-specific Regulator and Effector CD8+ T Cells, and HA-1 Microchimerism, in Allograft Tolerance
J. Exp. Med., April 5, 2004; 199(7): 1017 - 1023.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
B. Martin, A. Banz, B. Bienvenu, C. Cordier, N. Dautigny, C. Becourt, and B. Lucas
Suppression of CD4+ T Lymphocyte Effector Functions by CD4+CD25+ Cells In Vivo
J. Immunol., March 15, 2004; 172(6): 3391 - 3398.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
E. M. Aandahl, J. Michaelsson, W. J. Moretto, F. M. Hecht, and D. F. Nixon
Human CD4+ CD25+ Regulatory T Cells Control T-Cell Responses to Human Immunodeficiency Virus and Cytomegalovirus Antigens
J. Virol., March 1, 2004; 78(5): 2454 - 2459.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
X. Zhang, D. N. Koldzic, L. Izikson, J. Reddy, R. F. Nazareno, S. Sakaguchi, V. K. Kuchroo, and H. L. Weiner
IL-10 is involved in the suppression of experimental autoimmune encephalomyelitis by CD25+CD4+ regulatory T cells
Int. Immunol., February 1, 2004; 16(2): 249 - 256.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
L. A. Stephens, A. N. Barclay, and D. Mason
Phenotypic characterization of regulatory CD4+CD25+ T cells in rats
Int. Immunol., February 1, 2004; 16(2): 365 - 375.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. Karim, C. I. Kingsley, A. R. Bushell, B. S. Sawitzki, and K. J. Wood
Alloantigen-Induced CD25+CD4+ Regulatory T Cells Can Develop In Vivo from CD25-CD4+ Precursors in a Thymus-Independent Process
J. Immunol., January 15, 2004; 172(2): 923 - 928.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
L. E. Marra, Z. X. Zhang, B. Joe, J. Campbell, G. A. Levy, J. Penninger, and L. Zhang
IL-10 Induces Regulatory T Cell Apoptosis by Up-Regulation of the Membrane Form of TNF-{alpha}
J. Immunol., January 15, 2004; 172(2): 1028 - 1035.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. Andrassy, S. Kusaka, E. Jankowska-Gan, J. R. Torrealba, L. D. Haynes, B. R. Marthaler, R. C. Tam, B. M.-W. Illigens, N. Anosova, G. Benichou, et al.
Tolerance to Noninherited Maternal MHC Antigens in Mice
J. Immunol., November 15, 2003; 171(10): 5554 - 5561.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
S. Bozza, K. Perruccio, C. Montagnoli, R. Gaziano, S. Bellocchio, E. Burchielli, G. Nkwanyuo, L. Pitzurra, A. Velardi, and L. Romani
A dendritic cell vaccine against invasive aspergillosis in allogeneic hematopoietic transplantation
Blood, November 15, 2003; 102(10): 3807 - 3814.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. Gregori, N. Giarratana, S. Smiroldo, and L. Adorini
Dynamics of Pathogenic and Suppressor T Cells in Autoimmune Diabetes Development
J. Immunol., October 15, 2003; 171(8): 4040 - 4047.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
H. Nishikawa, T. Kato, K. Tanida, A. Hiasa, I. Tawara, H. Ikeda, Y. Ikarashi, H. Wakasugi, M. Kronenberg, T. Nakayama, et al.
CD4+ CD25+ T cells responding to serologically defined autoantigens suppress antitumor immune responses
PNAS, September 16, 2003; 100(19): 10902 - 10906.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
S. Jiang, N. Camara, G. Lombardi, and R. I. Lechler
Induction of allopeptide-specific human CD4+CD25+ regulatory T cells ex vivo
Blood, September 15, 2003; 102(6): 2180 - 2186.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
S. Fisson, G. Darrasse-Jeze, E. Litvinova, F. Septier, D. Klatzmann, R. Liblau, and B. L. Salomon
Continuous Activation of Autoreactive CD4+ CD25+ Regulatory T Cells in the Steady State
J. Exp. Med., September 2, 2003; 198(5): 737 - 746.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C. Asseman, S. Read, and F. Powrie
Colitogenic Th1 Cells Are Present in the Antigen-Experienced T Cell Pool in Normal Mice: Control by CD4+ Regulatory T Cells and IL-10
J. Immunol., July 15, 2003; 171(2): 971 - 978.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
T. Pearson, T. G. Markees, D. V. Serreze, M. A. Pierce, M. P. Marron, L. S. Wicker, L. B. Peterson, L. D. Shultz, J. P. Mordes, A. A. Rossini, et al.
Genetic Disassociation of Autoimmunity and Resistance to Costimulation Blockade-Induced Transplantation Tolerance in Nonobese Diabetic Mice
J. Immunol., July 1, 2003; 171(1): 185 - 195.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. Kataoka, J. A. Margenthaler, G. Ku, and M. W. Flye
Development of Infectious Tolerance After Donor-Specific Transfusion and Rat Heart Transplantation
J. Immunol., July 1, 2003; 171(1): 204 - 211.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C. Seifarth, S. Pop, B. Liu, C. P. Wong, and R. Tisch
More Stringent Conditions of Plasmid DNA Vaccination Are Required to Protect Grafted Versus Endogenous Islets in Nonobese Diabetic Mice
J. Immunol., July 1, 2003; 171(1): 469 - 476.
[Abstract] [Full Text] [PDF]

Home page
 Pharmacol. Rev.Home page
K. Asadullah, W. Sterry, and H. D. Volk
Interleukin-10 Therapy--Review of a New Approach
Pharmacol. Rev., June 1, 2003; 55(2): 241 - 269.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
A. D. Salama, N. Najafian, M. R. Clarkson, W. E. Harmon, and M. H. Sayegh
Regulatory CD25+ T Cells in Human Kidney Transplant Recipients
J. Am. Soc. Nephrol., June 1, 2003; 14(6): 1643 - 1651.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
Y. Zhai and J. W. Kupiec-Weglinski
Regulatory T Cells in Kidney Transplant Recipients: Active Players but to What Extent?
J. Am. Soc. Nephrol., June 1, 2003; 14(6): 1706 - 1708.
[Full Text] [PDF]

Home page
 BloodHome page
C. Guillot, S. Menoret, C. Guillonneau, C. Braudeau, M. G. Castro, P. Lowenstein, and I. Anegon
Active suppression of allogeneic proliferative responses by dendritic cells after induction of long-term allograft survival by CTLA4Ig
Blood, April 15, 2003; 101(8): 3325 - 3333.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
N. E. Phillips, T. G. Markees, J. P. Mordes, D. L. Greiner, and A. A. Rossini
Blockade of CD40-Mediated Signaling Is Sufficient for Inducing Islet But Not Skin Transplantation Tolerance
J. Immunol., March 15, 2003; 170(6): 3015 - 3023.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. Sundstedt, E. J. O'Neill, K. S. Nicolson, and D. C. Wraith
Role for IL-10 in Suppression Mediated by Peptide-Induced Regulatory T Cells In Vivo
J. Immunol., February 1, 2003; 170(3): 1240 - 1248.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
W.-P. Min, D. Zhou, T. E. Ichim, G. H. Strejan, X. Xia, J. Yang, X. Huang, B. Garcia, D. White, P. Dutartre, et al.
Inhibitory Feedback Loop Between Tolerogenic Dendritic Cells and Regulatory T Cells in Transplant Tolerance
J. Immunol., February 1, 2003; 170(3): 1304 - 1312.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
D. Yin, N. Dujovny, L. Ma, A. Varghese, J. Shen, D. K. Bishop, and A. S. Chong
IFN-{gamma} Production Is Specifically Regulated by IL-10 in Mice Made Tolerant with Anti-CD40 Ligand Antibody and Intact Active Bone
J. Immunol., January 15, 2003; 170(2): 853 - 860.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. Sho, A. Yamada, N. Najafian, A. D. Salama, H. Harada, S. E. Sandner, A. Sanchez-Fueyo, X. X. Zheng, T. B. Strom, and M. H. Sayegh
Physiological Mechanisms of Regulating Alloimmunity: Cytokines, CTLA-4, CD25+ Cells, and the Alloreactive T Cell Clone Size
J. Immunol., October 1, 2002; 169(7): 3744 - 3751.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
J. L. Cohen, A. Trenado, D. Vasey, D. Klatzmann, and B. L. Salomon
CD4+CD25+ Immunoregulatory T Cells: New Therapeutics for Graft-Versus-Host Disease
J. Exp. Med., August 5, 2002; 196(3): 401 - 406.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. Banz, C. Pontoux, and M. Papiernik
Modulation of Fas-Dependent Apoptosis: A Dynamic Process Controlling Both the Persistence and Death of CD4 Regulatory T Cells and Effector T Cells
J. Immunol., July 15, 2002; 169(2): 750 - 757.
[Abstract] [Full Text] [PDF]

Home page
 Rheumatology (Oxford)Home page
P. M. Cobelens, A. Kavelaars, R. van der Zee, W. van Eden, and C. J. Heijnen
Dynamics of mycobacterial HSP65-induced T-cell cytokine expression during oral tolerance induction in adjuvant arthritis
Rheumatology, July 1, 2002; 41(7): 775 - 779.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
S. Hori, M. Haury, A. Coutinho, and J. Demengeot
Specificity requirements for selection and effector functions of CD25+4+ regulatory T cells in anti-myelin basic protein T cell receptor transgenic mice
PNAS, June 11, 2002; 99(12): 8213 - 8218.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
L. Graca, S. Thompson, C.-Y. Lin, E. Adams, S. P. Cobbold, and H. Waldmann
Both CD4+CD25+ and CD4+CD25- Regulatory Cells Mediate Dominant Transplantation Tolerance
J. Immunol., June 1, 2002; 168(11): 5558 - 5565.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
P. A. Taylor, T. M. Friedman, R. Korngold, R. J. Noelle, and B. R. Blazar
Tolerance induction of alloreactive T cells via ex vivo blockade of the CD40:CD40L costimulatory pathway results in the generation of a potent immune regulatory cell
Blood, May 29, 2002; 99(12): 4601 - 4609.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 2001 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 2001 by The American Association of Immunologists, Inc. All rights reserved.