| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
14-J281 Transgenic Nonobese Diabetic Mice Is Associated with a Th2 Shift Circumscribed Regionally to the Islets and Functionally to Islet Autoantigen1
Institut National de la Santé et de la Recherche Médicale, Unité 25, Hôpital Necker, Paris, France
The onset of autoimmune diabetes is related to defective immune
regulation. Recent studies have shown that NK T cells are deficient in
number and function in both diabetic patients and nonobese diabetic
(NOD) mice. NK T cells, which are CD1d restricted, express a TCR with
an invariant V
14-J281 chain and rapidly produce large amounts of
cytokines. V14-J281 transgenic NOD mice have increased numbers of
NK T cells and are protected against diabetes onset. In this study we
analyzed where and how NK T cells interfere with the development of the
anti-islet autoimmune response. NK T cells, which are usually rare
in lymph nodes, are abundant in pancreatic lymph nodes and are also
present in islets. IL-4 mRNA levels are increased and IFN-
mRNA
levels decreased in islets from diabetes-free V14-J281 transgenic
NOD mice; the IgG1/IgG2c ratio of autoantibodies against glutamic acid
decarboxylase is also increased in these mice. Treatment with IL-12 (a
pro-Th1 cytokine) or anti-IL-4 Ab abolishes the diabetes protection
in V14-J281 NOD mice. The protection from diabetes conferred by
NK T cells is thus associated with a Th2 shift within islets directed
against autoantigen such as glutamic acid decarboxylase. Our findings
also demonstrate the key role of IL-4.
This article has been cited by other articles:
|
|
 |
|
  D. V. Baev, S. Caielli, F. Ronchi, M. Coccia, F. Facciotti, K. E. Nichols, and M. Falcone Impaired SLAM-SLAM Homotypic Interaction between Invariant NKT Cells and Dendritic Cells Affects Differentiation of IL-4/IL-10-Secreting NKT2 Cells in Nonobese Diabetic Mice J. Immunol., July 15, 2008; 181(2): 869 - 877. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Chen, G. Han, J. Wang, R. Wang, R. Xu, B. Shen, J. Qian, and Y. Li Induction of Active Tolerance and Involvement of CD1d-Restricted Natural Killer T Cells in Anti-CD3 F(ab')2 Treatment-Reversed New-Onset Diabetes in Nonobese Diabetic Mice Am. J. Pathol., April 1, 2008; 172(4): 972 - 979. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Wu and L. V. Kaer Role of NKT Cells in the Digestive System. II. NKT cells and diabetes Am J Physiol Gastrointest Liver Physiol, November 1, 2007; 293(5): G919 - G922. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Cain, J. A. Smith, J. K. Ondr, B. Wang, and J. D. Katz NKT Cells and IFN-{gamma} Establish the Regulatory Environment for the Control of Diabetogenic T Cells in the Nonobese Diabetic Mouse J. Immunol., February 1, 2006; 176(3): 1645 - 1654. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. C. Kent, Y. Chen, S. M. Clemmings, V. Viglietta, N. S. Kenyon, C. Ricordi, B. Hering, and D. A. Hafler Loss of IL-4 Secretion from Human Type 1a Diabetic Pancreatic Draining Lymph Node NKT Cells J. Immunol., October 1, 2005; 175(7): 4458 - 4464. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-Y. Ko, H.-J. Ko, W.-S. Chang, S.-H. Park, M.-N. Kweon, and C.-Y. Kang {alpha}-Galactosylceramide Can Act As a Nasal Vaccine Adjuvant Inducing Protective Immune Responses against Viral Infection and Tumor J. Immunol., September 1, 2005; 175(5): 3309 - 3317. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Griseri, L. Beaudoin, J. Novak, L. T. Mars, F. Lepault, R. Liblau, and A. Lehuen Invariant NKT Cells Exacerbate Type 1 Diabetes Induced by CD8 T Cells J. Immunol., August 15, 2005; 175(4): 2091 - 2101. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Jorns, A. Gunther, H.-J. Hedrich, D. Wedekind, M. Tiedge, and S. Lenzen Immune Cell Infiltration, Cytokine Expression, and {beta}-Cell Apoptosis During the Development of Type 1 Diabetes in the Spontaneously Diabetic LEW.1AR1/Ztm-iddm Rat Diabetes, July 1, 2005; 54(7): 2041 - 2052. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. D. Wagner, S. Hussain, M. Mehan, J. M. Verdi, and T. L. Delovitch A Defect in Lineage Fate Decision during Fetal Thymic Invariant NKT Cell Development May Regulate Susceptibility to Type 1 Diabetes J. Immunol., June 1, 2005; 174(11): 6764 - 6771. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Novak, L. Beaudoin, T. Griseri, and A. Lehuen Inhibition of T Cell Differentiation into Effectors by NKT Cells Requires Cell Contacts J. Immunol., February 15, 2005; 174(4): 1954 - 1961. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Machen, J. Harnaha, R. Lakomy, A. Styche, M. Trucco, and N. Giannoukakis Antisense Oligonucleotides Down-Regulating Costimulation Confer Diabetes-Preventive Properties to Nonobese Diabetic Mouse Dendritic Cells J. Immunol., October 1, 2004; 173(7): 4331 - 4341. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Duarte, M. Stenstrom, S. Campino, M.-L. Bergman, M. Lundholm, D. Holmberg, and S. L. Cardell Prevention of Diabetes in Nonobese Diabetic Mice Mediated by CD1d-Restricted Nonclassical NKT Cells J. Immunol., September 1, 2004; 173(5): 3112 - 3118. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Saito, A. Okumura, H. Watanabe, M. Asano, A. Ishida-Okawara, J. Sakagami, K. Sudo, Y. Hatano-Yokoe, J. S. Bezbradica, S. Joyce, et al. Increase in Hepatic NKT Cells in Leukocyte Cell-Derived Chemotaxin 2-Deficient Mice Contributes to Severe Concanavalin A-Induced Hepatitis J. Immunol., July 1, 2004; 173(1): 579 - 585. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Yang, A. Ueno, M. Bao, Z. Wang, J. S. Im, S. Porcelli, and J.-W. Yoon Control of NKT Cell Differentiation by Tissue-Specific Microenvironments J. Immunol., December 1, 2003; 171(11): 5913 - 5920. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Capone, D. Cantarella, J. Schumann, O. V. Naidenko, C. Garavaglia, F. Beermann, M. Kronenberg, P. Dellabona, H. R. MacDonald, and G. Casorati Human Invariant V{alpha}24-J{alpha}Q TCR Supports the Development of CD1d-Dependent NK1.1+ and NK1.1- T Cells in Transgenic Mice J. Immunol., March 1, 2003; 170(5): 2390 - 2398. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. T. Mars, V. Laloux, K. Goude, S. Desbois, A. Saoudi, L. Van Kaer, H. Lassmann, A. Herbelin, A. Lehuen, and R. S. Liblau Cutting Edge: V{alpha}14-J{alpha}281 NKT Cells Naturally Regulate Experimental Autoimmune Encephalomyelitis in Nonobese Diabetic Mice J. Immunol., June 15, 2002; 168(12): 6007 - 6011. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Laloux, L. Beaudoin, C. Ronet, and A. Lehuen Phenotypic and Functional Differences Between NKT Cells Colonizing Splanchnic and Peripheral Lymph Nodes J. Immunol., April 1, 2002; 168(7): 3251 - 3258. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
