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CUTTING EDGE |
T Cells Are Activated by Intermediates of the 2-C-methyl-D-erythritol 4-phosphate Pathway of Isoprenoid Biosynthesis1
*
Jomaa Pharmaka GmbH, Giessen, Germany;
Biochemisches Institut, Justus-Liebig-Universität Giessen, Giessen, Germany;
Departament de Bioquímica i Biología Molecular, Universitat de Barcelona, Barcelona, Spain; and
Institut Le Bel, Université Louis Pasteur/Centre National de la Recherche Scientifique, Strasbourg, France
Activation of V
9/V
2 T cells by small nonprotein Ags is
frequently observed after infection with various viruses, bacteria, and
eukaryotic parasites. We suggested earlier that compounds synthesized
by the 2-C-methyl-D-erythritol 4-phosphate
(MEP) pathway of isopentenyl pyrophosphate synthesis are responsible
for the V9/V2 T cell reactivity of many pathogens. Using
genetically engineered Escherichia coli knockout
strains, we now demonstrate that the ability of E. coli
extracts to stimulate T cell proliferation is abrogated when
genes coding for essential enzymes of the MEP pathway,
dxr or gcpE, are disrupted or deleted
from the bacterial genome.
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