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CUTTING EDGE |
*
Institut National de la Santé et de la Recherche Médicale, Unité 395, Centre Hospitalier Universitaire Purpan, BP3028;
Centre National de la Recherche Scientifique, Unité Mixte de Recherche 5089; and
Centre National de la Recherche Scientifique, Unité Propre de Recherche 2163, Centre Hospitalier Universitaire Purpan, BP3028, Toulouse, France
Upon encounter of a CTL with a target cell carrying foreign Ags, the TCR internalizes with its ligand, the peptide-MHC class I complex. However, it is unclear how this can happen mechanistically because MHC molecules are anchored to the target cell’s surface via a transmembrane domain. By using antigenic peptides and lipids that were fluorescently labeled, we found that CTLs promptly capture target cell membranes together with the antigenic peptide as well as various other surface proteins. This efficient and specific capture process requires sustained TCR signaling. Our observations indicate that this process allows efficient acquisition of the Ag by CTL, which may in turn regulate lymphocyte activation or elimination.
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