| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
CUTTING EDGE |
Departments of
*
Cell Biology and Immunology and
Medical Chemistry, Institute for Immunology and Inflammation, Faculty of Medicine, Vrije University, Amsterdam, The Netherlands;
Wellcome Trust Biocentre, University of Dundee, Dundee, United Kingdom;
The Biomedical Research Centre, University of British Columbia, Vancouver, British Columbia, Canada;
¶ Institute of Cell Biology, University of Muenster, Muenster, Germany; and
||
Glycobiology Program, Burnham Institute, La Jolla, CA 42037
Sialoadhesin (Siglec-1) is a macrophage-restricted sialic acid-binding receptor that mediates interactions with hemopoietic cells, including lymphocytes. In this study, we identify sialoadhesin counterreceptors on T lymphocytes. Several major glycoproteins (85, 130, 240 kDa) were precipitated by sialoadhesin-Fc fusion proteins from a murine T cell line (TK-1). Binding of sialoadhesin to these glycoproteins was sialic acid dependent and was abolished by mutation of a critical residue (R97A) of the sialic acid binding site in the membrane distal Ig-like domain of sialoadhesin. The 130- and 240-kDa sialoadhesin-binding glycoproteins were identified as the sialomucins CD43 and P-selectin glycoprotein ligand 1 (CD162), respectively. CD43 expressed in COS cells supported increased binding to immobilized sialoadhesin. Finally, sialoadhesin bound different glycoforms of CD43 expressed in Chinese hamster ovary cells, including unbranched (core 1) and branched (core 2) O-linked glycans, that are normally found on CD43 in resting and activated T cells, respectively. These results identify CD43 as a T cell counterreceptor for sialoadhesin and suggest that in addition to its anti-adhesive role CD43 may promote cell-cell interactions.
This article has been cited by other articles:
|
|
 |
|
  A. Varki Natural ligands for CD33-related Siglecs? Glycobiology, August 1, 2009; 19(8): 810 - 812. [Full Text] [PDF]
|
|
|
|
 |
|
 C. Wu, U. Rauch, E. Korpos, J. Song, K. Loser, P. R. Crocker, and L. M. Sorokin Sialoadhesin-Positive Macrophages Bind Regulatory T Cells, Negatively Controlling Their Expansion and Autoimmune Disease Progression J. Immunol., May 15, 2009; 182(10): 6508 - 6516. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Bax, J. J. Garcia-Vallejo, J. Jang-Lee, S. J. North, T. J. Gilmartin, G. Hernandez, P. R. Crocker, H. Leffler, S. R. Head, S. M. Haslam, et al. Dendritic Cell Maturation Results in Pronounced Changes in Glycan Expression Affecting Recognition by Siglecs and Galectins J. Immunol., December 15, 2007; 179(12): 8216 - 8224. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. L. Delputte, W. Van Breedam, I. Delrue, C. Oetke, P. R. Crocker, and H. J. Nauwynck Porcine Arterivirus Attachment to the Macrophage-Specific Receptor Sialoadhesin Is Dependent on the Sialic Acid-Binding Activity of the N-Terminal Immunoglobulin Domain of Sialoadhesin J. Virol., September 1, 2007; 81(17): 9546 - 9550. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Matsumoto, A. Shigeta, Y. Furukawa, T. Tanaka, M. Miyasaka, and T. Hirata CD43 Collaborates with P-Selectin Glycoprotein Ligand-1 to Mediate E-Selectin-Dependent T Cell Migration into Inflamed Skin J. Immunol., February 15, 2007; 178(4): 2499 - 2506. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Avril, S. J. North, S. M. Haslam, H. J. Willison, and P. R. Crocker Probing the cis interactions of the inhibitory receptor Siglec-7 with {alpha}2,8-disialylated ligands on natural killer cells and other leukocytes using glycan-specific antibodies and by analysis of {alpha}2,8-sialyltransferase gene expression J. Leukoc. Biol., October 1, 2006; 80(4): 787 - 796. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-R. Jiang, L. Hwenda, K. Makinen, C. Oetke, P. R. Crocker, and J. V. Forrester Sialoadhesin Promotes the Inflammatory Response in Experimental Autoimmune Uveoretinitis J. Immunol., August 15, 2006; 177(4): 2258 - 2264. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. A. Fierro, G. Pedraza-Alva, and Y. Rosenstein TCR-Dependent Cell Response Is Modulated by the Timing of CD43 Engagement. J. Immunol., June 15, 2006; 176(12): 7346 - 7353. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Oetke, M. C. Vinson, C. Jones, and P. R. Crocker Sialoadhesin-Deficient Mice Exhibit Subtle Changes in B- and T-Cell Populations and Reduced Immunoglobulin M Levels Mol. Cell. Biol., February 15, 2006; 26(4): 1549 - 1557. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. C. Fuhlbrigge, S. L. King, R. Sackstein, and T. S. Kupper CD43 is a ligand for E-selectin on CLA+ human T cells Blood, February 15, 2006; 107(4): 1421 - 1426. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Varki and T. Angata Siglecs--the major subfamily of I-type lectins Glycobiology, January 1, 2006; 16(1): 1R - 27R. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Matsumoto, K. Atarashi, E. Umemoto, Y. Furukawa, A. Shigeta, M. Miyasaka, and T. Hirata CD43 Functions as a Ligand for E-Selectin on Activated T Cells J. Immunol., December 15, 2005; 175(12): 8042 - 8050. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Alblas, H. Honing, C. Renardel de Lavalette, M. H. Brown, C. D. Dijkstra, and T. K. van den Berg Signal Regulatory Protein {alpha} Ligation Induces Macrophage Nitric Oxide Production through JAK/STAT- and Phosphatidylinositol 3-Kinase/Rac1/NAPDH Oxidase/H2O2-Dependent Pathways Mol. Cell. Biol., August 15, 2005; 25(16): 7181 - 7192. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. K. Randhawa, H. J. Ziltener, J. S. Merzaban, and R. W. Stokes CD43 Is Required for Optimal Growth Inhibition of Mycobacterium tuberculosis in Macrophages and in Mice J. Immunol., August 1, 2005; 175(3): 1805 - 1812. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Kirchberger, O. Majdic, P. Steinberger, S. Bluml, K. Pfistershammer, G. Zlabinger, L. Deszcz, E. Kuechler, W. Knapp, and J. Stockl Human Rhinoviruses Inhibit the Accessory Function of Dendritic Cells by Inducing Sialoadhesin and B7-H1 Expression J. Immunol., July 15, 2005; 175(2): 1145 - 1152. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. S. Bochner, R. A. Alvarez, P. Mehta, N. V. Bovin, O. Blixt, J. R. White, and R. L. Schnaar Glycan Array Screening Reveals a Candidate Ligand for Siglec-8 J. Biol. Chem., February 11, 2005; 280(6): 4307 - 4312. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Tong, E. J. Allenspach, S. M. Takahashi, P. D. Mody, C. Park, J. K. Burkhardt, and A. I. Sperling CD43 Regulation of T Cell Activation Is Not through Steric Inhibition of T Cell-APC Interactions but through an Intracellular Mechanism J. Exp. Med., May 3, 2004; 199(9): 1277 - 1283. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Vanderheijden, P. L. Delputte, H. W. Favoreel, J. Vandekerckhove, J. Van Damme, P. A. van Woensel, and H. J. Nauwynck Involvement of Sialoadhesin in Entry of Porcine Reproductive and Respiratory Syndrome Virus into Porcine Alveolar Macrophages J. Virol., August 1, 2003; 77(15): 8207 - 8215. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. D. Dick, D. Carter, M. Robertson, C. Broderick, E. Hughes, J. V. Forrester, and J. Liversidge Control of myeloid activity during retinal inflammation J. Leukoc. Biol., August 1, 2003; 74(2): 161 - 166. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. R. Todeschini, M. F. Girard, J.-M. Wieruszeski, M. P. Nunes, G. A. DosReis, L. Mendonca-Previato, and J. O. Previato trans-Sialidase from Trypanosoma cruzi Binds Host T-lymphocytes in a Lectin Manner J. Biol. Chem., November 22, 2002; 277(48): 45962 - 45968. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Da Silva, A. Bharti, and C. S. Shelley hnRNP-K and Puralpha act together to repress the transcriptional activity of the CD43 gene promoter Blood, November 15, 2002; 100(10): 3536 - 3544. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Barat and M. J. Tremblay Engagement of CD43 Enhances Human Immunodeficiency Virus Type 1 Transcriptional Activity and Virus Production That Is Induced upon TCR/CD3 Stimulation J. Biol. Chem., August 2, 2002; 277(32): 28714 - 28724. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. M. Onami, L. E. Harrington, M. A. Williams, M. Galvan, C. P. Larsen, T. C. Pearson, N. Manjunath, L. G. Baum, B. D. Pearce, and R. Ahmed Dynamic Regulation of T Cell Immunity by CD43 J. Immunol., June 15, 2002; 168(12): 6022 - 6031. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Grobe and L. D. Powell Role of protein kinase C in the phosphorylation of CD33 (Siglec-3) and its effect on lectin activity Blood, May 1, 2002; 99(9): 3188 - 3196. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Nakamura, T. Yamaji, P. R. Crocker, A. Suzuki, and Y. Hashimoto Lymph node macrophages, but not spleen macrophages, express high levels of unmasked sialoadhesin: implication for the adhesive properties of macrophages in vivo Glycobiology, March 1, 2002; 12(3): 209 - 216. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Cermak, S. Simova, A. Pintzas, V. Horejsi, and L. Andera Molecular Mechanisms Involved in CD43-mediated Apoptosis of TF-1 Cells. ROLES OF TRANSCRIPTION, Daxx EXPRESSION, AND ADHESION MOLECULES J. Biol. Chem., March 1, 2002; 277(10): 7955 - 7961. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
