HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Wangoo, A. Articles by Young, D. B. Search for Related Content PubMed PubMed Citation Articles by Wangoo, A. Articles by Young, D. B.

Contribution of Th1 and Th2 Cells to Protection and Pathology in Experimental Models of Granulomatous Lung Disease¹

Arun Wangoo^*, Tim Sparer^*, Ivor N. Brown, Valerie A. Snewin, Riny Janssen, Jelle Thole, H. Terence Cook, Rory J. Shaw^* and Douglas B. Young^2,

^* Department of Respiratory Medicine, National Heart and Lung Institute, and Departments of Infectious Diseases and Microbiology and Histopathology, Imperial College School of Medicine, London, United Kingdom

Mice that had received adoptive transfer of DO11.10 TCR transgenic T cells polarized toward a Th1 or a Th2 phenotype were challenged with Ag-coated beads or with recombinant Mycobacterium tuberculosis expressing the OVA determinant. The resulting bead-induced pulmonary granulomas reflected the phenotype of the adoptively transferred T cells, with the Th2 cells promoting a fibrotic reaction. Mice receiving Th1 cells mounted an epitope-specific protective response to challenge with recombinant M. tuberculosis. Th2 recipients were characterized by enhanced weight loss and lung fibrosis during acute high-dose infection. The combination of TCR transgenic T cells and epitope-tagged mycobacteria provides a novel experimental model for investigation of the pathogenesis of tuberculosis.

This article has been cited by other articles:

				A. M. Gallegos, E. G. Pamer, and M. S. Glickman Delayed protection by ESAT-6-specific effector CD4+ T cells after airborne M. tuberculosis infection J. Exp. Med., September 29, 2008; 205(10): 2359 - 2368. [Abstract] [Full Text] [PDF]

				J. Yamahana, T. Wada, K. Furuichi, N. Sakai, H. Yokoyama, and S. Kaneko TAK-603, an anti-inflammatory compound, reduces crescentic glomerulonephritis and preserves renal function in WKY rats Nephrol. Dial. Transplant., October 1, 2006; 21(10): 2736 - 2744. [Abstract] [Full Text] [PDF]

				K. Dheda, J.-S. Chang, R. A. M. Breen, L. U. Kim, J. A. Haddock, J. F. Huggett, M. A. Johnson, G. A. W. Rook, and A. Zumla In Vivo and In Vitro Studies of a Novel Cytokine, Interleukin 4{delta}2, in Pulmonary Tuberculosis Am. J. Respir. Crit. Care Med., August 15, 2005; 172(4): 501 - 508. [Abstract] [Full Text] [PDF]

				T. Nishiwaki, H. Yoneyama, Y. Eishi, N. Matsuo, K. Tatsumi, H. Kimura, T. Kuriyama, and K. Matsushima Indigenous Pulmonary Propionibacterium acnes Primes the Host in the Development of Sarcoid-Like Pulmonary Granulomatosis in Mice Am. J. Pathol., August 1, 2004; 165(2): 631 - 639. [Abstract] [Full Text] [PDF]

				M. Hesse, M. Modolell, A. C. La Flamme, M. Schito, J. M. Fuentes, A. W. Cheever, E. J. Pearce, and T. A. Wynn Differential Regulation of Nitric Oxide Synthase-2 and Arginase-1 by Type 1/Type 2 Cytokines In Vivo: Granulomatous Pathology Is Shaped by the Pattern of L-Arginine Metabolism J. Immunol., December 1, 2001; 167(11): 6533 - 6544. [Abstract] [Full Text] [PDF]

				C. G. Lee, R. J. Homer, Z. Zhu, S. Lanone, X. Wang, V. Koteliansky, J. M. Shipley, P. Gotwals, P. Noble, Q. Chen, et al. Interleukin-13 Induces Tissue Fibrosis by Selectively Stimulating and Activating Transforming Growth Factor {beta}1 J. Exp. Med., September 17, 2001; 194(6): 809 - 822. [Abstract] [Full Text] [PDF]