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Division of Rheumatic Diseases, University of Connecticut Health Center, Farmington, CT 06030; and
Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104
The intestinal mucosal CD8 T cell response to infection with
Listeria monocytogenes was measured using MHC class I
tetramers and was compared with the response in peripheral blood,
secondary lymphoid tissue, and liver. To assess the vaccination
potential of Listeria and to analyze responses in
C57BL/6 mouse strains, a recombinant Listeria expressing
OVA (rLM-ova) was generated. The response peaked at 9 days
postinfection with a much larger fraction of the intestinal mucosa and
liver CD8 T cell pool OVA specific, as compared with the spleen.
However, these differences were not linked to bacterial titers in each
site. The higher responses in lamina propria and liver resulted in a
larger CD8 memory population in these tissues. Furthermore, the level
of memory induced was dependent on infectious dose and inversely
correlated with the magnitude of the recall response after oral
challenge. Recall responses in the tissues were most robust in the
lamina propria and liver, and reactivated Ag-specific T cells produced
IFN-
. Infection of CD40- or MHC class II-deficient mice induced poor
CD8 T cell responses in the intestinal mucosa, but only partially
reduced responses in the spleen and liver. Overall, the results point
to novel pathways of tissue-specific regulation of primary and memory
antimicrobial CD8 T cell responses.
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J. S. Haring, V. P. Badovinac, M. R. Olson, S. M. Varga, and J. T. Harty In Vivo Generation of Pathogen-Specific Th1 Cells in the Absence of the IFN-{gamma} Receptor J. Immunol., September 1, 2005; 175(5): 3117 - 3122. [Abstract] [Full Text] [PDF]
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D. M. Lindell, T. A. Moore, R. A. McDonald, G. B. Toews, and G. B. Huffnagle Generation of Antifungal Effector CD8+ T Cells in the Absence of CD4+ T Cells during Cryptococcus neoformans Infection J. Immunol., June 15, 2005; 174(12): 7920 - 7928. [Abstract] [Full Text] [PDF]
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J. S. Haring, G. A. Corbin, and J. T. Harty Dynamic Regulation of IFN-{gamma} Signaling in Antigen-Specific CD8+ T Cells Responding to Infection J. Immunol., June 1, 2005; 174(11): 6791 - 6802. [Abstract] [Full Text] [PDF]
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F. Liu and J. L. Whitton Cutting Edge: Re-evaluating the In Vivo Cytokine Responses of CD8+ T Cells during Primary and Secondary Viral Infections J. Immunol., May 15, 2005; 174(10): 5936 - 5940. [Abstract] [Full Text] [PDF]
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 R. Irons, P. Pinge-Filho, and K. L. Fritsche Dietary (n-3) Polyunsaturated Fatty Acids Do Not Affect the In Vivo Development and Function of Listeria-Specific CD4+ and CD8+ Effector and Memory/Effector T Cells in Mice J. Nutr., May 1, 2005; 135(5): 1151 - 1156. [Abstract] [Full Text] [PDF]
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G. Tully, C. Kortsik, H. Hohn, I. Zehbe, W. E. Hitzler, C. Neukirch, K. Freitag, K. Kayser, and M. J. Maeurer Highly Focused T Cell Responses in Latent Human Pulmonary Mycobacterium tuberculosis Infection J. Immunol., February 15, 2005; 174(4): 2174 - 2184. [Abstract] [Full Text] [PDF]
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G. A. Corbin and J. T. Harty T Cells Undergo Rapid ON/OFF but Not ON/OFF/ON Cycling of Cytokine Production in Response to Antigen J. Immunol., January 15, 2005; 174(2): 718 - 726. [Abstract] [Full Text] [PDF]
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A. B. Kamath, J. Woodworth, X. Xiong, C. Taylor, Y. Weng, and S. M. Behar Cytolytic CD8+ T Cells Recognizing CFP10 Are Recruited to the Lung after Mycobacterium tuberculosis Infection J. Exp. Med., December 6, 2004; 200(11): 1479 - 1489. [Abstract] [Full Text] [PDF]
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