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Division of Rheumatic Diseases, University of Connecticut Health Center, Farmington, CT 06030; and
Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104
The intestinal mucosal CD8 T cell response to infection with
Listeria monocytogenes was measured using MHC class I
tetramers and was compared with the response in peripheral blood,
secondary lymphoid tissue, and liver. To assess the vaccination
potential of Listeria and to analyze responses in
C57BL/6 mouse strains, a recombinant Listeria expressing
OVA (rLM-ova) was generated. The response peaked at 9 days
postinfection with a much larger fraction of the intestinal mucosa and
liver CD8 T cell pool OVA specific, as compared with the spleen.
However, these differences were not linked to bacterial titers in each
site. The higher responses in lamina propria and liver resulted in a
larger CD8 memory population in these tissues. Furthermore, the level
of memory induced was dependent on infectious dose and inversely
correlated with the magnitude of the recall response after oral
challenge. Recall responses in the tissues were most robust in the
lamina propria and liver, and reactivated Ag-specific T cells produced
IFN-
. Infection of CD40- or MHC class II-deficient mice induced poor
CD8 T cell responses in the intestinal mucosa, but only partially
reduced responses in the spleen and liver. Overall, the results point
to novel pathways of tissue-specific regulation of primary and memory
antimicrobial CD8 T cell responses.
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P. Sinai, R. E. Berg, J. M. Haynie, M. J. Egorin, R. L. Ilaria Jr, and J. Forman Imatinib Mesylate Inhibits Antigen-Specific Memory CD8 T Cell Responses In Vivo J. Immunol., February 15, 2007; 178(4): 2028 - 2037. [Abstract] [Full Text] [PDF]
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J. S. Haring and J. T. Harty Aberrant Contraction of Antigen-Specific CD4 T Cells after Infection in the Absence of Gamma Interferon or Its Receptor Infect. Immun., November 1, 2006; 74(11): 6252 - 6263. [Abstract] [Full Text] [PDF]
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M. Prlic, G. Hernandez-Hoyos, and M. J. Bevan Duration of the initial TCR stimulus controls the magnitude but not functionality of the CD8+ T cell response J. Exp. Med., September 4, 2006; 203(9): 2135 - 2143. [Abstract] [Full Text] [PDF]
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A. Jabbari and J. T. Harty Secondary memory CD8+ T cells are more protective but slower to acquire a central-memory phenotype J. Exp. Med., April 17, 2006; 203(4): 919 - 932. [Abstract] [Full Text] [PDF]
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B. B. Porter and J. T. Harty The Onset of CD8+-T-Cell Contraction Is Influenced by the Peak of Listeria monocytogenes Infection and Antigen Display Infect. Immun., March 1, 2006; 74(3): 1528 - 1536. [Abstract] [Full Text] [PDF]
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K. E. Foulds and H. Shen Clonal Competition Inhibits the Proliferation and Differentiation of Adoptively Transferred TCR Transgenic CD4 T Cells in Response to Infection. J. Immunol., March 1, 2006; 176(5): 3037 - 3043. [Abstract] [Full Text] [PDF]
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H. Xu, T. Chun, H.-J. Choi, B. Wang, and C.-R. Wang Impaired response to Listeria in H2-M3-deficient mice reveals a nonredundant role of MHC class Ib-specific T cells in host defense J. Exp. Med., February 21, 2006; 203(2): 449 - 459. [Abstract] [Full Text] [PDF]
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 K. Yoshimura, A. Jain, H. E. Allen, L. S. Laird, C. Y. Chia, S. Ravi, D. G. Brockstedt, M. A. Giedlin, K. S. Bahjat, M. L. Leong, et al. Selective Targeting of Antitumor Immune Responses with Engineered Live-Attenuated Listeria monocytogenes Cancer Res., January 15, 2006; 66(2): 1096 - 1104. [Abstract] [Full Text] [PDF]
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E. Y. Kim, J. J. Priatel, S.-J. Teh, and H.-S. Teh TNF Receptor Type 2 (p75) Functions as a Costimulator for Antigen-Driven T Cell Responses In Vivo J. Immunol., January 15, 2006; 176(2): 1026 - 1035. [Abstract] [Full Text] [PDF]
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T. Zaft, A. Sapoznikov, R. Krauthgamer, D. R. Littman, and S. Jung CD11chigh Dendritic Cell Ablation Impairs Lymphopenia-Driven Proliferation of Naive and Memory CD8+ T Cells J. Immunol., November 15, 2005; 175(10): 6428 - 6435. [Abstract] [Full Text] [PDF]
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A. Ploss, I. Leiner, and E. G. Pamer Distinct Regulation of H2-M3-Restricted Memory T Cell Responses in Lymph Node and Spleen J. Immunol., November 1, 2005; 175(9): 5998 - 6005. [Abstract] [Full Text] [PDF]
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A. Jabbari and J. T. Harty Cutting Edge: Differential Self-Peptide/MHC Requirement for Maintaining CD8 T Cell Function versus Homeostatic Proliferation J. Immunol., October 15, 2005; 175(8): 4829 - 4833. [Abstract] [Full Text] [PDF]
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S. Bertholet, A. Debrabant, F. Afrin, E. Caler, S. Mendez, K. S. Tabbara, Y. Belkaid, and D. L. Sacks Antigen Requirements for Efficient Priming of CD8+ T Cells by Leishmania major-Infected Dendritic Cells Infect. Immun., October 1, 2005; 73(10): 6620 - 6628. [Abstract] [Full Text] [PDF]
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J. S. Haring, V. P. Badovinac, M. R. Olson, S. M. Varga, and J. T. Harty In Vivo Generation of Pathogen-Specific Th1 Cells in the Absence of the IFN-{gamma} Receptor J. Immunol., September 1, 2005; 175(5): 3117 - 3122. [Abstract] [Full Text] [PDF]
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K. M. Kerksiek, F. Niedergang, P. Chavrier, D. H. Busch, and T. Brocker Selective Rac1 inhibition in dendritic cells diminishes apoptotic cell uptake and cross-presentation in vivo Blood, January 15, 2005; 105(2): 742 - 749. [Abstract] [Full Text] [PDF]
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A. B. Kamath, J. Woodworth, X. Xiong, C. Taylor, Y. Weng, and S. M. Behar Cytolytic CD8+ T Cells Recognizing CFP10 Are Recruited to the Lung after Mycobacterium tuberculosis Infection J. Exp. Med., December 6, 2004; 200(11): 1479 - 1489. [Abstract] [Full Text] [PDF]
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W. Li, T. Yajima, K. Saito, H. Nishimura, T. Fushimi, Y. Ohshima, Y. Tsukamoto, and Y. Yoshikai Immunostimulating Properties of Intragastrically Administered Acetobacter-Derived Soluble Branched (1,4)-{beta}-D-Glucans Decrease Murine Susceptibility to Listeria monocytogenes Infect. Immun., December 1, 2004; 72(12): 7005 - 7011. [Abstract] [Full Text] [PDF]
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M. Pepper, F. Dzierszinski, A. Crawford, C. A. Hunter, and D. Roos Development of a System To Study CD4+-T-Cell Responses to Transgenic Ovalbumin-Expressing Toxoplasma gondii during Toxoplasmosis Infect. Immun., December 1, 2004; 72(12): 7240 - 7246. [Abstract] [Full Text] [PDF]
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A. C. Kirby, M. Sundquist, and M. J. Wick In Vivo Compartmentalization of Functionally Distinct, Rapidly Responsive Antigen-Specific T-Cell Populations in DNA-Immunized or Salmonella enterica Serovar Typhimurium-Infected Mice Infect. Immun., November 1, 2004; 72(11): 6390 - 6400. [Abstract] [Full Text] [PDF]
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G. A. Corbin and J. T. Harty Duration of Infection and Antigen Display Have Minimal Influence on the Kinetics of the CD4+ T Cell Response to Listeria monocytogenes Infection J. Immunol., November 1, 2004; 173(9): 5679 - 5687. [Abstract] [Full Text] [PDF]
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M. A. Cannarile, N. Decanis, J. P. M. van Meerwijk, and T. Brocker The Role of Dendritic Cells in Selection of Classical and Nonclassical CD8+ T Cells In Vivo J. Immunol., October 15, 2004; 173(8): 4799 - 4805. [Abstract] [Full Text] [PDF]
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M. J. Montfort, H. G. A. Bouwer, C. R. Wagner, and D. J. Hinrichs The Development of Functional CD8 T Cell Memory after Listeria monocytogenes Infection Is Not Dependent on CD40 J. Immunol., September 15, 2004; 173(6): 4084 - 4090. [Abstract] [Full Text] [PDF]
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A. Srinivasan, J. Foley, R. Ravindran, and S. J. McSorley Low-Dose Salmonella Infection Evades Activation of Flagellin-Specific CD4 T Cells J. Immunol., September 15, 2004; 173(6): 4091 - 4099. [Abstract] [Full Text] [PDF]
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A. L. Marzo, V. Vezys, K. D. Klonowski, S.-J. Lee, G. Muralimohan, M. Moore, D. F. Tough, and L. Lefrancois Fully Functional Memory CD8 T Cells in the Absence of CD4 T Cells J. Immunol., July 15, 2004; 173(2): 969 - 975. [Abstract] [Full Text] [PDF]
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H. Starks, K. W. Bruhn, H. Shen, R. A. Barry, T. W. Dubensky, D. Brockstedt, D. J. Hinrichs, D. E. Higgins, J. F. Miller, M. Giedlin, et al. Listeria monocytogenes as a Vaccine Vector: Virulence Attenuation or Existing Antivector Immunity Does Not Diminish Therapeutic Efficacy J. Immunol., July 1, 2004; 173(1): 420 - 427. [Abstract] [Full Text] [PDF]
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H. Lauterbach, K. M. Kerksiek, D. H. Busch, E. Berto, A. Bozac, P. Mavromara, R. Manservigi, A. L. Epstein, P. Marconi, and T. Brocker Protection from Bacterial Infection by a Single Vaccination with Replication-Deficient Mutant Herpes Simplex Virus Type 1 J. Virol., April 15, 2004; 78(8): 4020 - 4028. [Abstract] [Full Text] [PDF]
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J. C. Sun and M. J. Bevan Cutting Edge: Long-Lived CD8 Memory and Protective Immunity in the Absence of CD40 Expression on CD8 T Cells J. Immunol., March 15, 2004; 172(6): 3385 - 3389. [Abstract] [Full Text] [PDF]
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L.-X. Wang, J. Kjaergaard, P. A. Cohen, S. Shu, and G. E. Plautz Memory T Cells Originate from Adoptively Transferred Effectors and Reconstituting Host Cells after Sequential Lymphodepletion and Adoptive Immunotherapy J. Immunol., March 15, 2004; 172(6): 3462 - 3468. [Abstract] [Full Text] [PDF]
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 M. Kursar, H.-W. Mittrucker, M. Koch, A. Kohler, M. Herma, and S. H. E. Kaufmann Protective T cell response against intracellular pathogens in the absence of Toll-like receptor signaling via myeloid differentiation factor 88 Int. Immunol., March 1, 2004; 16(3): 415 - 421. [Abstract] [Full Text] [PDF]
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A. J. Tyznik, J. C. Sun, and M. J. Bevan The CD8 Population in CD4-deficient Mice Is Heavily Contaminated with MHC Class II-restricted T Cells J. Exp. Med., February 17, 2004; 199(4): 559 - 565. [Abstract] [Full Text] [PDF]
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C. Johansson and M. J. Wick Liver Dendritic Cells Present Bacterial Antigens and Produce Cytokines upon Salmonella Encounter J. Immunol., February 15, 2004; 172(4): 2496 - 2503. [Abstract] [Full Text] [PDF]
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R. E. Berg, E. Crossley, S. Murray, and J. Forman Memory CD8+ T Cells Provide Innate Immune Protection against Listeria monocytogenes in the Absence of Cognate Antigen J. Exp. Med., November 17, 2003; 198(10): 1583 - 1593. [Abstract] [Full Text] [PDF]
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J. C. Salazar, C. D. Pope, T. J. Sellati, H. M. Feder Jr, T. G. Kiely, K. R. Dardick, R. L. Buckman, M. W. Moore, M. J. Caimano, J. G. Pope, et al. Coevolution of Markers of Innate and Adaptive Immunity in Skin and Peripheral Blood of Patients with Erythema Migrans J. Immunol., September 1, 2003; 171(5): 2660 - 2670. [Abstract] [Full Text] [PDF]
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V. P. Badovinac, K. A. Nordyke Messingham, S. E. Hamilton, and J. T. Harty Regulation of CD8+ T Cells Undergoing Primary and Secondary Responses to Infection in the Same Host J. Immunol., May 15, 2003; 170(10): 4933 - 4942. [Abstract] [Full Text] [PDF]
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C. Peters, X. Peng, D. Douven, Z.-K. Pan, and Y. Paterson The Induction of HIV Gag-Specific CD8+ T Cells in the Spleen and Gut-Associated Lymphoid Tissue by Parenteral or Mucosal Immunization with Recombinant Listeria monocytogenes HIV Gag J. Immunol., May 15, 2003; 170(10): 5176 - 5187. [Abstract] [Full Text] [PDF]
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H. Saklani-Jusforgues, E. Fontan, N. Soussi, G. Milon, and P. L. Goossens Enteral Immunization with Attenuated Recombinant Listeria monocytogenes as a Live Vaccine Vector: Organ-Dependent Dynamics of CD4 T Lymphocytes Reactive to a Leishmania major Tracer Epitope Infect. Immun., March 1, 2003; 71(3): 1083 - 1090. [Abstract] [Full Text] [PDF]
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J. K. Leavey and R. L. Tarleton Cutting Edge: Dysfunctional CD8+ T Cells Reside in Nonlymphoid Tissues During Chronic Trypanosoma cruzi Infection J. Immunol., March 1, 2003; 170(5): 2264 - 2268. [Abstract] [Full Text] [PDF]
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D. J. Shedlock, J. K. Whitmire, J. Tan, A. S. MacDonald, R. Ahmed, and H. Shen Role of CD4 T Cell Help and Costimulation in CD8 T Cell Responses During Listeria monocytogenes Infection J. Immunol., February 15, 2003; 170(4): 2053 - 2063. [Abstract] [Full Text] [PDF]
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H.-W. Mittrucker, M. Kursar, A. Kohler, D. Yanagihara, S. K. Yoshinaga, and S. H. E. Kaufmann Inducible Costimulator Protein Controls the Protective T Cell Response Against Listeria monocytogenes J. Immunol., November 15, 2002; 169(10): 5813 - 5817. [Abstract] [Full Text] [PDF]
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L.-Y. Kwok, H. Miletic, S. Lutjen, S. Soltek, M. Deckert, and D. Schluter Protective Immunosurveillance of the Central Nervous System by Listeria-Specific CD4 and CD8 T Cells in Systemic Listeriosis in the Absence of Intracerebral Listeria J. Immunol., August 15, 2002; 169(4): 2010 - 2019. [Abstract] [Full Text] [PDF]
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M. Kursar, K. Bonhagen, A. Kohler, T. Kamradt, S. H. E. Kaufmann, and H.-W. Mittrucker Organ-Specific CD4+ T Cell Response During Listeria monocytogenes Infection J. Immunol., June 15, 2002; 168(12): 6382 - 6387. [Abstract] [Full Text] [PDF]
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W. N. D'Souza, K. S. Schluns, D. Masopust, and L. Lefrancois Essential Role for IL-2 in the Regulation of Antiviral Extralymphoid CD8 T Cell Responses J. Immunol., June 1, 2002; 168(11): 5566 - 5572. [Abstract] [Full Text] [PDF]
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A. L. Marzo, V. Vezys, K. Williams, D. F. Tough, and L. Lefrancois Tissue-Level Regulation of Th1 and Th2 Primary and Memory CD4 T Cells in Response to Listeria Infection J. Immunol., May 1, 2002; 168(9): 4504 - 4510. [Abstract] [Full Text] [PDF]
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K. E. Foulds, L. A. Zenewicz, D. J. Shedlock, J. Jiang, A. E. Troy, and H. Shen Cutting Edge: CD4 and CD8 T Cells Are Intrinsically Different in Their Proliferative Responses J. Immunol., February 15, 2002; 168(4): 1528 - 1532. [Abstract] [Full Text] [PDF]
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M. Rayevskaya, N. Kushnir, and F. R. Frankel Safety and Immunogenicity in Neonatal Mice of a Hyperattenuated Listeria Vaccine Directed against Human Immunodeficiency Virus J. Virol., January 15, 2002; 76(2): 918 - 922. [Abstract] [Full Text] [PDF]
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