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Impaired Pulmonary Host Defense in Mice Lacking Expression of the CXC Chemokine Lungkine¹

Shu-Cheng Chen^*, Borna Mehrad, Jane C. Deng, Galya Vassileva^*, Denise J. Manfra^*, Donald N. Cook^*, Maria T. Wiekowski^*, Albert Zlotnik, Theodore J. Standiford and Sergio A. Lira^2,*

^* Department of Immunology, Schering-Plough Research Institute, Kenilworth, NJ 07033; Division of Pulmonary and Critical Care Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390; Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan Medical School, Ann Arbor, MI 48109; and DNAX Research Institute, Palo Alto, CA 94304

Lungkine (CXCL15) is a novel CXC chemokine that is highly expressed in the adult mouse lung. To determine the biologic function of Lungkine, we generated Lungkine null mice by targeted gene disruption. These mice did not differ from wild-type mice in their hematocrits or in the relative number of cells in leukocyte populations of peripheral blood or other tissues, including lung and bone marrow. However, Lungkine null mice were more susceptible to Klebsiella pneumonia infection, with a decreased survival and increased lung bacterial burden compared with infected wild-type mice. Histologic analysis of the lung and assessment of leukocytes in the bronchioalveolar lavage revealed that neutrophil numbers were normal in the lung parenchyma, but reduced in the airspace. The production of other neutrophil chemoattractants in the Lungkine null mice did not differ from that in wild-type mice, and neutrophil migration into other tissues was normal. Taken together, these findings demonstrate that Lungkine is an important mediator of neutrophil migration from the lung parenchyma into the airspace.

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