HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Hsu, P.-N. Articles by Huber, B. T. Search for Related Content PubMed PubMed Citation Articles by Hsu, P.-N. Articles by Huber, B. T.

Association of Mouse Mammary Tumor Virus Superantigen with MHC Class II During Biosynthesis¹

Ping-Ning Hsu^2,*, Paula Wolf Bryant^3,, Natalie Sutkowski^*, Brian McLellan^*, Hidde L. Ploegh and Brigitte T. Huber^6,*

^* Program in Immunology, Department of Pathology, Tufts University School of Medicine, Boston, MA 02111; and Department of Pathology, Harvard Medical School, Boston, MA 02115

Mouse mammary tumor viruses encode superantigens that interact with MHC class II proteins and stimulate T cells. We show here that presentation of mouse mammary tumor virus superantigen does not require DM. Furthermore, we have identified a strong class II peptide binding motif in the Mtv-7 superantigen, and we show that this motif is necessary for association with class II molecules in in vitro translation and in vivo functional assays. Our results suggest that endogenously synthesized viral superantigen can bind to MHC class II heterodimers during biosynthesis in the endoplasmic reticulum in a manner analogous to that used by the class II-associated invariant chain.

This article has been cited by other articles:

				G. A. Azar, R.-P. Sekaly, and J. Thibodeau A Defective Viral Superantigen-Presenting Phenotype in HLA-DR Transfectants Is Corrected by CIITA J. Immunol., June 15, 2005; 174(12): 7548 - 7557. [Abstract] [Full Text] [PDF]

				J. Neumann, A. M. Eis-Hubinger, and N. Koch Herpes Simplex Virus Type 1 Targets the MHC Class II Processing Pathway for Immune Evasion J. Immunol., September 15, 2003; 171(6): 3075 - 3083. [Abstract] [Full Text] [PDF]

				S. Wirth, A. Vessaz, C. Krummenacher, F. Baribaud, H. Acha-Orbea, and H. Diggelmann Regions of Mouse Mammary Tumor Virus Superantigen Involved in Interaction with the Major Histocompatibility Complex Class II I-A Molecule J. Virol., October 2, 2002; 76(21): 11172 - 11175. [Abstract] [Full Text] [PDF]