| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Unité du Développement des Lymphocytes, Centre National de la Recherche Scientifique, Unité de Recherche Associée 1961, Institut Pasteur, Paris, France
The mechanisms by which the immune system achieves constant T cell numbers throughout life, thereby controlling autoaggressive cell expansions, are to date not completely understood. Here, we show that the CD25+ subpopulation of naturally activated (CD45RBlow) CD4 T cells, but not CD25- CD45RBlow CD4 T cells, inhibits the accumulation of cotransferred CD45RBhigh CD4 T cells in lymphocyte-deficient mice. However, both CD25+ and CD25- CD45RBlow CD4 T cell subpopulations contain regulatory cells, since they can prevent naive CD4 T cell-induced wasting disease. In the absence of a correlation between disease and the number of recovered CD4+ cells, we conclude that expansion control and disease prevention are largely independent processes. CD25+ CD45RBlow CD4 T cells from IL-10-deficient mice do not protect from disease. They accumulate to a higher cell number and cannot prevent the expansion of CD45RBhigh CD4 T cells upon transfer compared with their wild-type counterparts. Although CD25+ CD45RBlow CD4 T cells are capable of expanding when transferred in vivo, they reach a homeostatic equilibrium at lower cell numbers than CD25- CD45RBlow or CD45RBhigh CD4 T cells. We conclude that CD25+ CD45RBlow CD4 T cells from nonmanipulated mice control the number of peripheral CD4 T cells through a mechanism involving the production of IL-10 by regulatory T cells.
This article has been cited by other articles:
|
|
 |
|
  A. Fragale, L. Gabriele, E. Stellacci, P. Borghi, E. Perrotti, R. Ilari, A. Lanciotti, A. L. Remoli, M. Venditti, F. Belardelli, et al. IFN Regulatory Factor-1 Negatively Regulates CD4+CD25+ Regulatory T Cell Differentiation by Repressing Foxp3 Expression J. Immunol., August 1, 2008; 181(3): 1673 - 1682. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. J. Winstead, J. M. Fraser, and A. Khoruts Regulatory CD4+CD25+Foxp3+ T Cells Selectively Inhibit the Spontaneous Form of Lymphopenia-Induced Proliferation of Naive T Cells J. Immunol., June 1, 2008; 180(11): 7305 - 7317. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Fang, G. C. Sharp, and H. Braley-Mullen Interleukin-10 Promotes Resolution of Granulomatous Experimental Autoimmune Thyroiditis Am. J. Pathol., June 1, 2008; 172(6): 1591 - 1602. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Carvalho-Gaspar, N. D. Jones, S. Luo, L. Martin, M. O. Brook, and K. J. Wood Location and Time-Dependent Control of Rejection by Regulatory T Cells Culminates in a Failure to Generate Memory T Cells J. Immunol., May 15, 2008; 180(10): 6640 - 6648. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Wakkach, S. Augier, J.-P. Breittmayer, C. Blin-Wakkach, and G. F. Carle Characterization of IL-10-Secreting T Cells Derived from Regulatory CD4+CD25+ Cells by the TIRC7 Surface Marker J. Immunol., May 1, 2008; 180(9): 6054 - 6063. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Hu, K. Fernando, H. Ni, and D. Weissman HIV Envelope Suppresses CD4+ T Cell Activation Independent of T Regulatory Cells J. Immunol., April 15, 2008; 180(8): 5593 - 5600. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Mirmonsef, G. Tan, G. Zhou, T. Morino, K. Noonan, I. Borrello, and H. I. Levitsky Escape from suppression: tumor-specific effector cells outcompete regulatory T cells following stem-cell transplantation Blood, February 15, 2008; 111(4): 2112 - 2121. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-G. Chai, D. Coe, D. Chen, E. Simpson, J. Dyson, and D. Scott In Vitro Expansion Improves In Vivo Regulation by CD4+CD25+ Regulatory T Cells J. Immunol., January 15, 2008; 180(2): 858 - 869. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Zhou, L. L'italien, D. Hodges, and X. M. Schebye Pivotal Roles of CD4+ Effector T cells in Mediating Agonistic Anti-GITR mAb-Induced-Immune Activation and Tumor Immunity in CT26 Tumors J. Immunol., December 1, 2007; 179(11): 7365 - 7375. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C.-W. Lee, V. P. Rao, A. B. Rogers, Z. Ge, S. E. Erdman, M. T. Whary, and J. G. Fox Wild-Type and Interleukin-10-Deficient Regulatory T Cells Reduce Effector T-Cell-Mediated Gastroduodenitis in Rag2-/- Mice, but Only Wild-Type Regulatory T Cells Suppress Helicobacter pylori Gastritis Infect. Immun., June 1, 2007; 75(6): 2699 - 2707. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. E. Pereira, F. Villinger, N. Onlamoon, P. Bryan, A. Cardona, K. Pattanapanysat, K. Mori, S. Hagen, L. Picker, and A. A. Ansari Simian Immunodeficiency Virus (SIV) Infection Influences the Level and Function of Regulatory T Cells in SIV-Infected Rhesus Macaques but Not SIV-Infected Sooty Mangabeys J. Virol., May 1, 2007; 81(9): 4445 - 4456. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Baatar, P. Olkhanud, K. Sumitomo, D. Taub, R. Gress, and A. Biragyn Human Peripheral Blood T Regulatory Cells (Tregs), Functionally Primed CCR4+ Tregs and Unprimed CCR4- Tregs, Regulate Effector T Cells Using FasL J. Immunol., April 15, 2007; 178(8): 4891 - 4900. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. L. Bayer, A. Yu, and T. R. Malek Function of the IL-2R for Thymic and Peripheral CD4+CD25+ Foxp3+ T Regulatory Cells J. Immunol., April 1, 2007; 178(7): 4062 - 4071. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Joetham, K. Takada, C. Taube, N. Miyahara, S. Matsubara, T. Koya, Y.-H. Rha, A. Dakhama, and E. W. Gelfand Naturally Occurring Lung CD4+CD25+ T Cell Regulation of Airway Allergic Responses Depends on IL-10 Induction of TGF-beta J. Immunol., February 1, 2007; 178(3): 1433 - 1442. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Nagato, H. Kobayashi, M. Yanai, K. Sato, N. Aoki, K. Oikawa, S. Kimura, Y. Abe, E. Celis, Y. Harabuchi, et al. Functional Analysis of Birch Pollen Allergen Bet v 1-Specific Regulatory T Cells J. Immunol., January 15, 2007; 178(2): 1189 - 1198. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Zelenay, A. Chora, M. P. Soares, and J. Demengeot Heme oxygenase-1 is not required for mouse regulatory T cell development and function Int. Immunol., January 1, 2007; 19(1): 11 - 18. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. M. Venturi, R. M. Conway, D. A. Steeber, and T. F. Tedder CD25+CD4+ Regulatory T Cell Migration Requires L-Selectin Expression: L-Selectin Transcriptional Regulation Balances Constitutive Receptor Turnover J. Immunol., January 1, 2007; 178(1): 291 - 300. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-L. Hillebrands, B. Whalen, J. T. J. Visser, J. Koning, K. D. Bishop, J. Leif, J. Rozing, J. P. Mordes, D. L. Greiner, and A. A. Rossini A Regulatory CD4+ T Cell Subset in the BB Rat Model of Autoimmune Diabetes Expresses Neither CD25 Nor Foxp3 J. Immunol., December 1, 2006; 177(11): 7820 - 7832. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. OFFNER and M. POLANCZYK A Potential Role for Estrogen in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis Ann. N.Y. Acad. Sci., November 1, 2006; 1089(1): 343 - 372. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Tischner, A. Weishaupt, J. v. d. Brandt, N. Muller, N. Beyersdorf, C. W. Ip, K. V. Toyka, T. Hunig, R. Gold, T. Kerkau, et al. Polyclonal expansion of regulatory T cells interferes with effector cell migration in a model of multiple sclerosis Brain, October 1, 2006; 129(10): 2635 - 2647. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Mahajan, Y. Wang, X. Qin, Y. Wang, G. Zheng, Y. M. Wang, S. I. Alexander, and D. C.H. Harris CD4+CD25+ Regulatory T Cells Protect against Injury in an Innate Murine Model of Chronic Kidney Disease J. Am. Soc. Nephrol., October 1, 2006; 17(10): 2731 - 2741. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Kryczek, S. Wei, L. Zou, G. Zhu, P. Mottram, H. Xu, L. Chen, and W. Zou Cutting Edge: Induction of B7-H4 on APCs through IL-10: Novel Suppressive Mode for Regulatory T Cells J. Immunol., July 1, 2006; 177(1): 40 - 44. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. R. M. Almeida, B. Zaragoza, and A. A. Freitas Indexation as a Novel Mechanism of Lymphocyte Homeostasis: The Number of CD4+CD25+ Regulatory T Cells Is Indexed to the Number of IL-2-Producing Cells J. Immunol., July 1, 2006; 177(1): 192 - 200. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Noble, A. Giorgini, and J. A. Leggat Cytokine-induced IL-10-secreting CD8 T cells represent a phenotypically distinct suppressor T-cell lineage Blood, June 1, 2006; 107(11): 4475 - 4483. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Beyer, M. Kochanek, T. Giese, E. Endl, M. R. Weihrauch, P. A. Knolle, S. Classen, and J. L. Schultze In vivo peripheral expansion of naive CD4+CD25high FoxP3+ regulatory T cells in patients with multiple myeloma Blood, May 15, 2006; 107(10): 3940 - 3949. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Gad, D. Lundsgaard, S. Kjellev, N. N Kristensen, T. Seremet, P. t. Straten, and M. H Claesson Reactivity of naive CD4+CD25- T cells against gut microflora in healthy mice Int. Immunol., May 1, 2006; 18(5): 817 - 825. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Baumgart, F. Tompkins, J. Leng, and M. Hesse Naturally Occurring CD4+Foxp3+ Regulatory T Cells Are an Essential, IL-10-Independent Part of the Immunoregulatory Network in Schistosoma mansoni Egg-Induced Inflammation J. Immunol., May 1, 2006; 176(9): 5374 - 5387. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Baecher-Allan, E. Wolf, and D. A. Hafler MHC class II expression identifies functionally distinct human regulatory T cells. J. Immunol., April 15, 2006; 176(8): 4622 - 4631. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Ono, J. Shimizu, Y. Miyachi, and S. Sakaguchi Control of Autoimmune Myocarditis and Multiorgan Inflammation by Glucocorticoid-Induced TNF Receptor Family-Related Proteinhigh, Foxp3-Expressing CD25+ and CD25- Regulatory T Cells. J. Immunol., April 15, 2006; 176(8): 4748 - 4756. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Barao, A. M. Hanash, W. Hallett, L. A. Welniak, K. Sun, D. Redelman, B. R. Blazar, R. B. Levy, and W. J. Murphy Suppression of natural killer cell-mediated bone marrow cell rejection by CD4+CD25+ regulatory T cells PNAS, April 4, 2006; 103(14): 5460 - 5465. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. S. Longhi, M. J. Hussain, R. R. Mitry, S. K. Arora, G. Mieli-Vergani, D. Vergani, and Y. Ma Functional Study of CD4+CD25+ Regulatory T Cells in Health and Autoimmune Hepatitis J. Immunol., April 1, 2006; 176(7): 4484 - 4491. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Lepage and R. Lapointe Melanosomal Targeting Sequences from gp100 Are Essential for MHC Class II-Restricted Endogenous Epitope Presentation and Mobilization to Endosomal Compartments Cancer Res., February 15, 2006; 66(4): 2423 - 2432. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Ghoreishi and J. P. Dutz Tolerance Induction by Transcutaneous Immunization through Ultraviolet-Irradiated Skin Is Transferable through CD4+CD25+ T Regulatory Cells and Is Dependent on Host-Derived IL-10 J. Immunol., February 15, 2006; 176(4): 2635 - 2644. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. G. Zheng, L. Meng, J. H. Wang, M. Watanabe, M. L. Barr, D. V. Cramer, J. D. Gray, and D. A. Horwitz Transfer of regulatory T cells generated ex vivo modifies graft rejection through induction of tolerogenic CD4+CD25+ cells in the recipient Int. Immunol., February 1, 2006; 18(2): 279 - 289. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. D. Zwar, S. Read, I. R. van Driel, and P. A. Gleeson CD4+CD25+ Regulatory T Cells Inhibit the Antigen-Dependent Expansion of Self-Reactive T Cells In Vivo J. Immunol., February 1, 2006; 176(3): 1609 - 1617. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Mesel-Lemoine, M. Cherai, S. Le Gouvello, M. Guillot, V. Leclercq, D. Klatzmann, V. Thomas-Vaslin, and F. M. Lemoine Initial depletion of regulatory T cells: the missing solution to preserve the immune functions of T lymphocytes designed for cell therapy Blood, January 1, 2006; 107(1): 381 - 388. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. K. Asiedu, K. J. Goodwin, G. Balgansuren, S. M. Jenkins, S. Le Bas-Bernardet, U. Jargal, D. M. Neville Jr, and J. M. Thomas Elevated T Regulatory Cells in Long-Term Stable Transplant Tolerance in Rhesus Macaques Induced by Anti-CD3 Immunotoxin and Deoxyspergualin J. Immunol., December 15, 2005; 175(12): 8060 - 8068. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. T. Endharti, M. Rifa' I, Z. Shi, Y. Fukuoka, Y. Nakahara, Y. Kawamoto, K. Takeda, K.-i. Isobe, and H. Suzuki Cutting Edge: CD8+CD122+ Regulatory T Cells Produce IL-10 to Suppress IFN-{gamma} Production and Proliferation of CD8+ T Cells J. Immunol., December 1, 2005; 175(11): 7093 - 7097. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. K. Sojka, A. Hughson, T. L. Sukiennicki, and D. J. Fowell Early Kinetic Window of Target T Cell Susceptibility to CD25+ Regulatory T Cell Activity J. Immunol., December 1, 2005; 175(11): 7274 - 7280. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Chen, A. E. Herman, M. Matos, D. Mathis, and C. Benoist Where CD4+CD25+ T reg cells impinge on autoimmune diabetes J. Exp. Med., November 21, 2005; 202(10): 1387 - 1397. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Ruiz-Perez, D. R. Chung, A. H. Sharpe, H. Yagita, W. M. Kalka-Moll, M. H. Sayegh, D. L. Kasper, and A. O. Tzianabos Modulation of surgical fibrosis by microbial zwitterionic polysaccharides PNAS, November 15, 2005; 102(46): 16753 - 16758. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Annacker, J. L. Coombes, V. Malmstrom, H. H. Uhlig, T. Bourne, B. Johansson-Lindbom, W. W. Agace, C. M. Parker, and F. Powrie Essential role for CD103 in the T cell-mediated regulation of experimental colitis J. Exp. Med., October 17, 2005; 202(8): 1051 - 1061. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Huang, J. Zhu, and Y. Yang Protection against Autoimmunity in Nonlymphopenic Hosts by CD4+CD25+ Regulatory T Cells Is Antigen-Specific and Requires IL-10 and TGF-{beta} J. Immunol., October 1, 2005; 175(7): 4283 - 4291. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. L. Denning, G. Kim, and M. Kronenberg Cutting Edge: CD4+CD25+ Regulatory T Cells Impaired for Intestinal Homing Can Prevent Colitis J. Immunol., June 15, 2005; 174(12): 7487 - 7491. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Pace, C. Pioli, and G. Doria IL-4 Modulation of CD4+CD25+ T Regulatory Cell-Mediated Suppression J. Immunol., June 15, 2005; 174(12): 7645 - 7653. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Darrasse-Jeze, G. Marodon, B. L. Salomon, M. Catala, and D. Klatzmann Ontogeny of CD4+CD25+ regulatory/suppressor T cells in human fetuses Blood, June 15, 2005; 105(12): 4715 - 4721. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E TOUBI, A KESSEL, Z MAHMUDOV, K HALLAS, M ROZENBAUM, and I ROSNER Increased Spontaneous Apoptosis of CD4+CD25+ T Cells in Patients with Active Rheumatoid Arthritis Is Reduced by Infliximab Ann. N.Y. Acad. Sci., June 1, 2005; 1051(1): 506 - 514. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. G. Heuer, T. Zhang, J. Zhao, C. Ding, M. Cramer, K. L. Justen, S. L. Vonderfecht, and S. Na Adoptive Transfer of In Vitro-Stimulated CD4+CD25+ Regulatory T Cells Increases Bacterial Clearance and Improves Survival in Polymicrobial Sepsis J. Immunol., June 1, 2005; 174(11): 7141 - 7146. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Verginis, H. S. Li, and G. Carayanniotis Tolerogenic Semimature Dendritic Cells Suppress Experimental Autoimmune Thyroiditis by Activation of Thyroglobulin-Specific CD4+CD25+ T Cells J. Immunol., June 1, 2005; 174(11): 7433 - 7439. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. S. Kang and P. M. Allen Priming in the Presence of IL-10 Results in Direct Enhancement of CD8+ T Cell Primary Responses and Inhibition of Secondary Responses J. Immunol., May 1, 2005; 174(9): 5382 - 5389. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Lundsgaard, T. L. Holm, L. Hornum, and H. Markholst In Vivo Control of Diabetogenic T-Cells by Regulatory CD4+CD25+ T-Cells Expressing Foxp3 Diabetes, April 1, 2005; 54(4): 1040 - 1047. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. M. Thorstenson, L. Herzovi, and A. Khoruts A model of suppression of the antigen-specific CD4 T cell response by regulatory CD25+CD4 T cells in vivo Int. Immunol., April 1, 2005; 17(4): 335 - 342. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. P. Eggena, B. Barugahare, N. Jones, M. Okello, S. Mutalya, C. Kityo, P. Mugyenyi, and H. Cao Depletion of Regulatory T Cells in HIV Infection Is Associated with Immune Activation J. Immunol., April 1, 2005; 174(7): 4407 - 4414. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Zelenay, T. Lopes-Carvalho, I. Caramalho, M. F. Moraes-Fontes, M. Rebelo, and J. Demengeot Foxp3+ CD25- CD4 T cells constitute a reservoir of committed regulatory cells that regain CD25 expression upon homeostatic expansion PNAS, March 15, 2005; 102(11): 4091 - 4096. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Setoguchi, S. Hori, T. Takahashi, and S. Sakaguchi Homeostatic maintenance of natural Foxp3+ CD25+ CD4+ regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization J. Exp. Med., March 7, 2005; 201(5): 723 - 735. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Barthlott, H. Moncrieffe, M. Veldhoen, C. J. Atkins, J. Christensen, A. O'Garra, and B. Stockinger CD25+CD4+ T cells compete with naive CD4+ T cells for IL-2 and exploit it for the induction of IL-10 production Int. Immunol., March 1, 2005; 17(3): 279 - 288. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Freeman, B.-C. Chiu, V. R. Stolberg, J. Hu, K. Zeibecoglou, N. W. Lukacs, S. A. Lira, S. L. Kunkel, and S. W. Chensue CCR8 Is Expressed by Antigen-Elicited, IL-10-Producing CD4+CD25+ T Cells, Which Regulate Th2-Mediated Granuloma Formation in Mice J. Immunol., February 15, 2005; 174(4): 1962 - 1970. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Hanash and R. B. Levy Donor CD4+CD25+ T cells promote engraftment and tolerance following MHC-mismatched hematopoietic cell transplantation Blood, February 15, 2005; 105(4): 1828 - 1836. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C Veltkamp, R B Sartor, T Giese, F Autschbach, I Kaden, R Veltkamp, D Rost, B Kallinowski, and W Stremmel Regulatory CD4+CD25+ cells reverse imbalances in the T cell pool of bone marrow transplanted TG{varepsilon}26 mice leading to the prevention of colitis Gut, February 1, 2005; 54(2): 207 - 214. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. J. Workman and D. A. A. Vignali Negative Regulation of T Cell Homeostasis by Lymphocyte Activation Gene-3 (CD223) J. Immunol., January 15, 2005; 174(2): 688 - 695. [Abstract] [Full Text] [PDF]
|
|
