| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
*
Institute for Virology and Immunobiology, University of Wurzburg, Wurzburg, Germany; and
Department of Molecular and Cell Biology and Cancer Research Laboratory, University of California, Berkeley, CA 94720
Inhibitory receptors specific for MHC class I molecules are expressed on partially overlapping subpopulations of NK cells and memory T cells. A central question pertinent to NK cell development and function is how the combinatorial expression of different receptors with distinct class I specificities affects functional recognition. We therefore studied the quantitative effects resulting from class I engagement of multiple inhibitory Ly49 receptors. We used a transgenic mouse model in which all NK cells and T cells express two different Ly49 receptors with shared class I specificity. Comparisons of cells from these mice with cells from single transgenic mice and wild-type mice revealed that Ly49 receptors cumulatively inhibit lymphocyte effector functions. Multiple Ly49 interactions also had a cumulative impact on NK cell development. The findings suggest that the interactions of inhibitory receptors with class I are interpreted quantitatively rather than as on/off switches. They have intriguing implications concerning NK cell tolerance and reactivity toward cells with extinguished expression of a limited number of class I molecules.
This article has been cited by other articles:
|
|
 |
|
  N. T. Joncker, N. C. Fernandez, E. Treiner, E. Vivier, and D. H. Raulet NK Cell Responsiveness Is Tuned Commensurate with the Number of Inhibitory Receptors for Self-MHC Class I: The Rheostat Model J. Immunol., April 15, 2009; 182(8): 4572 - 4580. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Scarpellino, F. Oeschger, P. Guillaume, J. D. Coudert, F. Levy, G. Leclercq, and W. Held Interactions of Ly49 Family Receptors with MHC Class I Ligands in trans and cis J. Immunol., February 1, 2007; 178(3): 1277 - 1284. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. C. Fernandez, E. Treiner, R. E. Vance, A. M. Jamieson, S. Lemieux, and D. H. Raulet A subset of natural killer cells achieves self-tolerance without expressing inhibitory receptors specific for self-MHC molecules Blood, June 1, 2005; 105(11): 4416 - 4423. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. M. Tanamachi, D. C. Moniot, D. Cado, S. D. Liu, J. K. Hsia, and D. H. Raulet Genomic Ly49A Transgenes: Basis of Variegated Ly49A Gene Expression and Identification of a Critical Regulatory Element J. Immunol., January 15, 2004; 172(2): 1074 - 1082. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S.-H. Lee, A. Zafer, Y. de Repentigny, R. Kothary, M. L. Tremblay, P. Gros, P. Duplay, J. R. Webb, and S. M. Vidal Transgenic Expression of the Activating Natural Killer Receptor Ly49H Confers Resistance to Cytomegalovirus in Genetically Susceptible Mice J. Exp. Med., February 17, 2003; 197(4): 515 - 526. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Morris, J. Liu, V. Arora, T. C. George, J. Klem, J. D. Schatzle, V. Kumar, and M. Bennett B6 Strain Ly49I Inhibitory Gene Expression on T Cells in FVB.Ly49IB6 Transgenic Mice Fails to Prevent Normal T Cell Functions J. Immunol., October 1, 2002; 169(7): 3661 - 3666. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Ioannidis, J. Zimmer, F. Beermann, and W. Held Cre Recombinase-Mediated Inactivation of H-2Dd Transgene Expression: Evidence for Partial Missing Self-Recognition by Ly49A NK Cells J. Immunol., December 1, 2001; 167(11): 6256 - 6262. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
