HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Gourley, T. S. Articles by Chang, C.-H. Search for Related Content PubMed PubMed Citation Articles by Gourley, T. S. Articles by Chang, C.-H. Pubmed/NCBI databases Compound via MeSH Substance via MeSH Hazardous Substances DB 12-O-TETRADECANOYLPHORBOL-13-ACETATE

Cutting Edge: The Class II Transactivator Prevents Activation-Induced Cell Death by Inhibiting Fas Ligand Gene Expression¹

Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109

The Fas:Fas ligand pathway is critical in regulating immune homeostasis by eliminating activated T cells that proliferated in response to an infection. Here, we show that the MHC class II transactivator (CIITA) can suppress this pathway by inhibiting transcription of the Fas ligand gene. CIITA can effectively repress transcription from the Fas ligand promoter in both T cell lines as well as primary cells. The repression appears to be at least partly due to interference of NFAT-mediated induction of Fas ligand gene transcription. T cells that express CIITA constitutively do not up-regulate Fas ligand on the cell surface after activation via the TCR. Consequently, these cells lack the ability to undergo activation-induced cell death, and to kill Fas-bearing target cells.

This article has been cited by other articles:

				X. Wu, X. Kong, L. Luchsinger, B. D. Smith, and Y. Xu Regulating the Activity of Class II Transactivator by Posttranslational Modifications: Exploring the Possibilities Mol. Cell. Biol., November 1, 2009; 29(21): 5639 - 5644. [Abstract] [Full Text] [PDF]

				K. Harnesk, M. Swanberg, J. Ockinger, M. Diez, O. Lidman, E. Wallstrom, A. Lobell, T. Olsson, and F. Piehl Vra4 Congenic Rats with Allelic Differences in the Class II Transactivator Gene Display Altered Susceptibility to Experimental Autoimmune Encephalomyelitis J. Immunol., March 1, 2008; 180(5): 3289 - 3296. [Abstract] [Full Text] [PDF]

				Y. Xu, J. A. Harton, and B. D. Smith CIITA Mediates Interferon-{gamma} Repression of Collagen Transcription through Phosphorylation-dependent Interactions with Co-repressor Molecules J. Biol. Chem., January 18, 2008; 283(3): 1243 - 1256. [Abstract] [Full Text] [PDF]

				A. Rivera and S. A. Maxwell The p53-induced Gene-6 (Proline Oxidase) Mediates Apoptosis through a Calcineurin-dependent Pathway J. Biol. Chem., August 12, 2005; 280(32): 29346 - 29354. [Abstract] [Full Text] [PDF]

				P. Sengupta, Y. Xu, L. Wang, R. Widom, and B. D. Smith Collagen {alpha}1(I) Gene (COL1A1) Is Repressed by RFX Family J. Biol. Chem., June 3, 2005; 280(22): 21004 - 21014. [Abstract] [Full Text] [PDF]

				N. Askenasy, E. S. Yolcu, I. Yaniv, and H. Shirwan Induction of tolerance using Fas ligand: a double-edged immunomodulator Blood, February 15, 2005; 105(4): 1396 - 1404. [Abstract] [Full Text] [PDF]

				C. S. K. Yee, Y. Yao, Q. Xu, B. McCarthy, D. Sun-Lin, M. Tone, H. Waldmann, and C.-H. Chang Enhanced Production of IL-10 by Dendritic Cells Deficient in CIITA J. Immunol., February 1, 2005; 174(3): 1222 - 1229. [Abstract] [Full Text] [PDF]

				Y. Xu, L. Wang, G. Buttice, P. K. Sengupta, and B. D. Smith Major Histocompatibility Class II Transactivator (CIITA) Mediates Repression of Collagen (COL1A2) Transcription by Interferon {gamma} (IFN-{gamma}) J. Biol. Chem., October 1, 2004; 279(40): 41319 - 41332. [Abstract] [Full Text] [PDF]

				W. S. Park, Y. Bae, D. H. Chung, Y.-L. Choi, B. K. Kim, Y. C. Sung, E. Y. Choi, S. H. Park, and K. C. Jung T cell expression of CIITA represses Th1 immunity Int. Immunol., October 1, 2004; 16(10): 1355 - 1364. [Abstract] [Full Text] [PDF]

				S. Nozell, Z. Ma, C. Wilson, R. Shah, and E. N. Benveniste Class II Major Histocompatibility Complex Transactivator (CIITA) Inhibits Matrix Metalloproteinase-9 Gene Expression J. Biol. Chem., September 10, 2004; 279(37): 38577 - 38589. [Abstract] [Full Text] [PDF]

				C. S. K. Yee, Y. Yao, P. Li, M. J. Klemsz, J. S. Blum, and C.-H. Chang Cathepsin E: A Novel Target for Regulation by Class II Transactivator J. Immunol., May 1, 2004; 172(9): 5528 - 5534. [Abstract] [Full Text] [PDF]

				S. Cenci, G. Toraldo, M. N. Weitzmann, C. Roggia, Y. Gao, W. P. Qian, O. Sierra, and R. Pacifici Estrogen deficiency induces bone loss by increasing T cell proliferation and lifespan through IFN-{gamma}-induced class II transactivator PNAS, September 2, 2003; 100(18): 10405 - 10410. [Abstract] [Full Text] [PDF]

				E. V. Acosta Rodriguez, E. Zuniga, C. L. Montes, and A. Gruppi Interleukin-4 biases differentiation of B cells from Trypanosoma cruzi-infected mice and restrains their fratricide: role of Fas ligand down-regulation and MHC class II-transactivator up-regulation J. Leukoc. Biol., January 1, 2003; 73(1): 127 - 136. [Abstract] [Full Text] [PDF]

				U. M. Nagarajan, A. Bushey, and J. M. Boss Modulation of Gene Expression by the MHC Class II Transactivator J. Immunol., November 1, 2002; 169(9): 5078 - 5088. [Abstract] [Full Text] [PDF]

				G. Barbieri, V. Deffrennes, T. Prod'homme, J. Vedrenne, F. Baton, C. Cortes, A. Fischer, M.-R. Bono, B. Lisowska-Grospierre, D. Charron, et al. Isoforms of the class II transactivator protein Int. Immunol., August 1, 2002; 14(8): 839 - 848. [Abstract] [Full Text] [PDF]

				P. K. Sengupta, J. Fargo, and B. D. Smith The RFX Family Interacts at the Collagen (COL1A2) Start Site and Represses Transcription J. Biol. Chem., July 5, 2002; 277(28): 24926 - 24937. [Abstract] [Full Text] [PDF]

				A. C. Morris, G. W. Beresford, M. R. Mooney, and J. M. Boss Kinetics of a Gamma Interferon Response: Expression and Assembly of CIITA Promoter IV and Inhibition by Methylation Mol. Cell. Biol., July 1, 2002; 22(13): 4781 - 4791. [Abstract] [Full Text] [PDF]

				R. Naves, A. M. Lennon, G. Barbieri, L. Reyes, G. Puga, L. Salas, V. Deffrennes, M. Rosemblatt, M. Fellous, D. Charron, et al. MHC class II-deficient tumor cell lines with a defective expression of the class II transactivator Int. Immunol., May 1, 2002; 14(5): 481 - 491. [Abstract] [Full Text] [PDF]

				T. S. Gourley, D. R. Patel, K. Nickerson, S.-C. Hong, and C.-H. Chang Aberrant Expression of Fas Ligand in Mice Deficient for the MHC Class II Transactivator J. Immunol., May 1, 2002; 168(9): 4414 - 4419. [Abstract] [Full Text] [PDF]

				T. M. Holling, N. van der Stoep, E. Quinten, and P. J. van den Elsen Activated Human T Cells Accomplish MHC Class II Expression Through T Cell-Specific Occupation of Class II Transactivator Promoter III J. Immunol., January 15, 2002; 168(2): 763 - 770. [Abstract] [Full Text] [PDF]

				J. Roger, A. Chalifour, S. Lemieux, and P. Duplay Cutting Edge: Ly49A Inhibits TCR/CD3-Induced Apoptosis and IL-2 Secretion J. Immunol., July 1, 2001; 167(1): 6 - 10. [Abstract] [Full Text] [PDF]

				V. Deffrennes, J. Vedrenne, M.-C. Stolzenberg, J. Piskurich, G. Barbieri, J. P. Ting, D. Charron, and C. Alcaide-Loridan Constitutive Expression of MHC Class II Genes in Melanoma Cell Lines Results from the Transcription of Class II Transactivator Abnormally Initiated from Its B Cell-Specific Promoter J. Immunol., July 1, 2001; 167(1): 98 - 106. [Abstract] [Full Text] [PDF]

				A. Kretsovali, C. Spilianakis, A. Dimakopoulos, T. Makatounakis, and J. Papamatheakis Self-association of Class II Transactivator Correlates with Its Intracellular Localization and Transactivation J. Biol. Chem., August 17, 2001; 276(34): 32191 - 32197. [Abstract] [Full Text] [PDF]