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The Journal of Immunology, 2001, 166: 2824-2830.
Copyright © 2001 by The American Association of Immunologists

Differential Susceptibility of Heart, Skin, and Islet Allografts to T Cell-Mediated Rejection1

Nick D. Jones2,3,*, Stuart E. Turvey3,*, Andre Van Maurik*, Masaki Hara4,*, Cherry I. Kingsley*, Clare H. Smith*, Andrew L. Mellor*, Peter J. Morris{dagger} and Kathryn J. Wood*

* Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom; and {dagger} Medical College of Georgia, Institute of Molecular Medicine and Genetics, Augusta, GA 30912

Although it is widely accepted that there is a hierarchy in the susceptibility of different allografts to rejection, the mechanisms responsible are unknown. We show that the increased susceptibility of H-2Kb+ skin and islet allografts to rejection is not based on their ability to activate more H-2Kb-specific T cells in vivo; heart allografts stimulate the activation and proliferation of many more H-2Kb-specific T cells than either skin or islet allografts. Rejection of all three types of graft generate memory cells by 25 days posttransplant. These data provide evidence that neither tissue-specific Ags nor, surprisingly, the number of APCs carried in the graft dictate their susceptibility to T cell-mediated rejection and suggest that the graft microenvironment and size may play a more important role in determining the susceptibility of an allograft to rejection and resistance to tolerance induction.




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