The JI PBL Intereron Source
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Dummer, W.
Right arrow Articles by Surh, C. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Dummer, W.
Right arrow Articles by Surh, C. D.
The Journal of Immunology, 2001, 166: 2460-2468.
Copyright © 2001 by The American Association of Immunologists

Autologous Regulation of Naive T Cell Homeostasis Within the T Cell Compartment1

Wolfgang Dummer, Bettina Ernst, Eric LeRoy, Dong-Sup Lee2 and Charles D. Surh3

Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037

Naive T cells undergo spontaneous slow proliferation on adoptive transfer into syngeneic T cell (T)-deficient hosts. Recent work has shown that such "homeostatic" T cell proliferation is driven by MHC molecules loaded with self-peptides rather than foreign peptides. Because naive T cells in normal T-sufficient hosts remain in interphase despite continuous contact with self-MHC/peptide ligands, T cells apparently inhibit homeostatic proliferation of neighboring T cells. To address this, we have investigated the requirements necessary for "bystander" T cells to inhibit homeostatic proliferation of other T cells. Three key findings are reported. First, homeostatic proliferation of T cells only occurs in specific microenvironments, namely the T cell compartment of the secondary lymphoid tissues. Second, direct entry into T cell compartments is also required for bystander inhibition of homeostatic proliferation. Third, bystander inhibition is mediated largely by naive rather than activated/memory T cells and does not require proliferation or TCR ligation. These findings suggest that homeostasis of naive T cells is unlikely to be regulated through competition for systemic soluble factors or for specific stimulatory self-MHC/peptide ligands. Rather, the data favor mechanisms that involve competition for local non-MHC stimulatory factors or direct cell-to-cell interactions between the T cells themselves within the T cell compartment.




This article has been cited by other articles:


Home page
 J. Immunol.Home page
V. F. Moxham, J. Karegli, R. E. Phillips, K. L. Brown, T. T. Tapmeier, R. Hangartner, S. H. Sacks, and W. Wong
Homeostatic Proliferation of Lymphocytes Results in Augmented Memory-Like Function and Accelerated Allograft Rejection
J. Immunol., March 15, 2008; 180(6): 3910 - 3918.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
R. Dudani, M. Russell, H. van Faassen, L. Krishnan, and S. Sad
Mutation in the Fas Pathway Impairs CD8+ T Cell Memory
J. Immunol., March 1, 2008; 180(5): 2933 - 2941.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
L. Strauss, C. Bergmann, W. Gooding, J. T. Johnson, and T. L. Whiteside
The Frequency and Suppressor Function of CD4+CD25highFoxp3+ T Cells in the Circulation of Patients with Squamous Cell Carcinoma of the Head and Neck
Clin. Cancer Res., November 1, 2007; 13(21): 6301 - 6311.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
H.-P. Raue and M. K. Slifka
Pivotal Advance: CTLA-4+ T cells exhibit normal antiviral functions during acute viral infection
J. Leukoc. Biol., May 1, 2007; 81(5): 1165 - 1175.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
I. E. Brown, C. Blank, J. Kline, A. K. Kacha, and T. F. Gajewski
Homeostatic Proliferation as an Isolated Variable Reverses CD8+ T Cell Anergy and Promotes Tumor Rejection
J. Immunol., October 1, 2006; 177(7): 4521 - 4529.
[Abstract] [Full Text] [PDF]

Home page
 Biophys. JHome page
J. R. Wedagedera and N. J. Burroughs
T-Cell Activation: A Queuing Theory Analysis at Low Agonist Density
Biophys. J., September 1, 2006; 91(5): 1604 - 1618.
[Abstract] [Full Text] [PDF]

Home page
 CVIHome page
T. W. Schacker, J. M. Brenchley, G. J. Beilman, C. Reilly, S. E. Pambuccian, J. Taylor, D. Skarda, M. Larson, D. C. Douek, and A. T. Haase
Lymphatic Tissue Fibrosis Is Associated with Reduced Numbers of Naive CD4+ T Cells in Human Immunodeficiency Virus Type 1 Infection.
Clin. Vaccine Immunol., May 1, 2006; 13(5): 556 - 560.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
P. J. Staton, A. B. Carpenter, and S. H. Jackman
IL-7 Is a Critical Factor in Modulating Lesion Development in Skn-Directed Autoimmunity
J. Immunol., April 1, 2006; 176(7): 3978 - 3986.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
R. M. Ribeiro, M. D. Hazenberg, A. S. Perelson, and M. P. Davenport
Naive and Memory Cell Turnover as Drivers of CCR5-to-CXCR4 Tropism Switch in Human Immunodeficiency Virus Type 1: Implications for Therapy
J. Virol., January 15, 2006; 80(2): 802 - 809.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
D. Homann, W. Dummer, T. Wolfe, E. Rodrigo, A. N. Theofilopoulos, M. B. A. Oldstone, and M. G. von Herrath
Lack of Intrinsic CTLA-4 Expression Has Minimal Effect on Regulation of Antiviral T-Cell Immunity
J. Virol., January 1, 2006; 80(1): 270 - 280.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
T. Zaft, A. Sapoznikov, R. Krauthgamer, D. R. Littman, and S. Jung
CD11chigh Dendritic Cell Ablation Impairs Lymphopenia-Driven Proliferation of Naive and Memory CD8+ T Cells
J. Immunol., November 15, 2005; 175(10): 6428 - 6435.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. Su, R. E. Berg, S. Murray, and J. Forman
Thymus-Dependent Memory Phenotype CD8 T Cells in Naive B6.H-2Kb-/-Db-/- Animals Mediate an Antigen-Specific Response against Listeria monocytogenes
J. Immunol., November 15, 2005; 175(10): 6450 - 6457.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
L. Gattinoni, S. E. Finkelstein, C. A. Klebanoff, P. A. Antony, D. C. Palmer, P. J. Spiess, L. N. Hwang, Z. Yu, C. Wrzesinski, D. M. Heimann, et al.
Removal of homeostatic cytokine sinks by lymphodepletion enhances the efficacy of adoptively transferred tumor-specific CD8+ T cells
J. Exp. Med., October 3, 2005; 202(7): 907 - 912.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
K. A. Fortner and R. C. Budd
The Death Receptor Fas (CD95/APO-1) Mediates the Deletion of T Lymphocytes Undergoing Homeostatic Proliferation
J. Immunol., October 1, 2005; 175(7): 4374 - 4382.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
A. M. Marleau and N. Sarvetnick
T cell homeostasis in tolerance and immunity
J. Leukoc. Biol., September 1, 2005; 78(3): 575 - 584.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
N. Bosco, F. Agenes, and R. Ceredig
Effects of Increasing IL-7 Availability on Lymphocytes during and after Lymphopenia-Induced Proliferation
J. Immunol., July 1, 2005; 175(1): 162 - 170.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. Gruber and T. Brocker
MHC Class I-Positive Dendritic Cells (DC) Control CD8 T Cell Homeostasis In Vivo: T Cell Lymphopenia as a Prerequisite for DC-Mediated Homeostatic Proliferation of Naive CD8 T Cells
J. Immunol., July 1, 2005; 175(1): 201 - 206.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
B. Min, H. Yamane, J. Hu-Li, and W. E. Paul
Spontaneous and Homeostatic Proliferation of CD4 T Cells Are Regulated by Different Mechanisms
J. Immunol., May 15, 2005; 174(10): 6039 - 6044.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
I. Messaoudi, J. LeMaoult, J. A. Guevara-Patino, B. M. Metzner, and J. Nikolich-Zugich
Age-related CD8 T Cell Clonal Expansions Constrict CD8 T Cell Repertoire and Have the Potential to Impair Immune Defense
J. Exp. Med., November 15, 2004; 200(10): 1347 - 1358.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
B. A. Sullivan, L. M. Reed-Loisel, G. J. Kersh, and P. E. Jensen
Homeostatic Proliferation of a Qa-1b-Restricted T Cell: A Distinction between the Ligands Required for Positive Selection and for Proliferation in Lymphopenic Hosts
J. Immunol., November 15, 2004; 173(10): 6065 - 6071.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. A. Mihalyo, A. D. H. Doody, J. P. McAleer, E. C. Nowak, M. Long, Y. Yang, and A. J. Adler
In Vivo Cyclophosphamide and IL-2 Treatment Impedes Self-Antigen-Induced Effector CD4 Cell Tolerization: Implications for Adoptive Immunotherapy
J. Immunol., May 1, 2004; 172(9): 5338 - 5345.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
B. Min, G. Foucras, M. Meier-Schellersheim, and W. E. Paul
Spontaneous proliferation, a response of naive CD4 T cells determined by the diversity of the memory cell repertoire
PNAS, March 16, 2004; 101(11): 3874 - 3879.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
Q. Ge, A. Bai, B. Jones, H. N. Eisen, and J. Chen
Competition for self-peptide-MHC complexes and cytokines between naive and memory CD8+ T cells expressing the same or different T cell receptors
PNAS, March 2, 2004; 101(9): 3041 - 3046.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
T. Schuler, G. J. Hammerling, and B. Arnold
Cutting Edge: IL-7-Dependent Homeostatic Proliferation of CD8+ T Cells in Neonatal Mice Allows the Generation of Long-Lived Natural Memory T Cells
J. Immunol., January 1, 2004; 172(1): 15 - 19.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
W. C. Kieper, J. T. Burghardt, and C. D. Surh
A Role for TCR Affinity in Regulating Naive T Cell Homeostasis
J. Immunol., January 1, 2004; 172(1): 40 - 44.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. L. Cornish, M. M. Chong, G. M. Davey, R. Darwiche, N. A. Nicola, D. J. Hilton, T. W. Kay, R. Starr, and W. S. Alexander
Suppressor of Cytokine Signaling-1 Regulates Signaling in Response to Interleukin-2 and Other {gamma}c-dependent Cytokines in Peripheral T Cells
J. Biol. Chem., June 13, 2003; 278(25): 22755 - 22761.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
Z. Kurepa, J. Su, and J. Forman
Memory Phenotype of CD8+ T Cells in MHC Class Ia-Deficient Mice
J. Immunol., June 1, 2003; 170(11): 5414 - 5420.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
B. Martin, C. Bourgeois, N. Dautigny, and B. Lucas
On the role of MHC class II molecules in the survival and lymphopenia-induced proliferation of peripheral CD4+ T cells
PNAS, May 13, 2003; 100(10): 6021 - 6026.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
T. Barthlott, G. Kassiotis, and B. Stockinger
T Cell Regulation as a Side Effect of Homeostasis and Competition
J. Exp. Med., February 17, 2003; 197(4): 451 - 460.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
C. T. Moses, K. M. Thorstenson, S. C. Jameson, and A. Khoruts
Competition for self ligands restrains homeostatic proliferation of naive CD4 T cells
PNAS, February 4, 2003; 100(3): 1185 - 1190.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. E. Troy and H. Shen
Cutting Edge: Homeostatic Proliferation of Peripheral T Lymphocytes Is Regulated by Clonal Competition
J. Immunol., January 15, 2003; 170(2): 672 - 676.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. S. Cabatingan, M. R. Schmidt, R. Sen, and R. T. Woodland
Naive B Lymphocytes Undergo Homeostatic Proliferation in Response to B Cell Deficit
J. Immunol., December 15, 2002; 169(12): 6795 - 6805.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. H. Yen, N. Lepak, and S. L. Swain
Induction of CD4 T Cell Changes in Murine AIDS Is Dependent on Costimulation and Involves a Dysregulation of Homeostasis
J. Immunol., July 15, 2002; 169(2): 722 - 731.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
J. T. Tan, B. Ernst, W. C. Kieper, E. LeRoy, J. Sprent, and C. D. Surh
Interleukin (IL)-15 and IL-7 Jointly Regulate Homeostatic Proliferation of Memory Phenotype CD8+ Cells but Are Not Required for Memory Phenotype CD4+ Cells
J. Exp. Med., June 17, 2002; 195(12): 1523 - 1532.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
R. S. McHugh and E. M. Shevach
Cutting Edge: Depletion of CD4+CD25+ Regulatory T Cells Is Necessary, But Not Sufficient, for Induction of Organ-Specific Autoimmune Disease
J. Immunol., June 15, 2002; 168(12): 5979 - 5983.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
S. Kimmig, G. K. Przybylski, C. A. Schmidt, K. Laurisch, B. Mowes, A. Radbruch, and A. Thiel
Two Subsets of Naive T Helper Cells with Distinct T Cell Receptor Excision Circle Content in Human Adult Peripheral Blood
J. Exp. Med., March 18, 2002; 195(6): 789 - 794.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
Q. Ge, D. Palliser, H. N. Eisen, and J. Chen
Homeostatic T cell proliferation in a T cell-dendritic cell coculture system
PNAS, February 14, 2002; (2002) 52714199.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
Z. Dai and F. G. Lakkis
Cutting Edge: Secondary Lymphoid Organs Are Essential for Maintaining the CD4, But Not CD8, Naive T Cell Pool
J. Immunol., December 15, 2001; 167(12): 6711 - 6715.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
J. Geginat, F. Sallusto, and A. Lanzavecchia
Cytokine-driven Proliferation and Differentiation of Human Naive, Central Memory, and Effector Memory CD4+ T Cells
J. Exp. Med., December 10, 2001; 194(12): 1711 - 1720.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
B. R. Lawson, S. I. Koundouris, M. Barnhouse, W. Dummer, R. Baccala, D. H. Kono, and A. N. Theofilopoulos
The Role of {alpha}{beta}+ T Cells and Homeostatic T Cell Proliferation in Y-Chromosome-Associated Murine Lupus
J. Immunol., August 15, 2001; 167(4): 2354 - 2360.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
J. T. Tan, E. Dudl, E. LeRoy, R. Murray, J. Sprent, K. I. Weinberg, and C. D. Surh
IL-7 is critical for homeostatic proliferation and survival of naive T cells
PNAS, July 5, 2001; (2001) 161126098.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
Q. Ge, D. Palliser, H. N. Eisen, and J. Chen
Homeostatic T cell proliferation in a T cell-dendritic cell coculture system
PNAS, March 5, 2002; 99(5): 2983 - 2988.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
J. T. Tan, E. Dudl, E. LeRoy, R. Murray, J. Sprent, K. I. Weinberg, and C. D. Surh
IL-7 is critical for homeostatic proliferation and survival of naive T cells
PNAS, July 17, 2001; 98(15): 8732 - 8737.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 2001 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 2001 by The American Association of Immunologists, Inc. All rights reserved.