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*
Division of Immunology, Department of Medicine, University of Connecticut Health Center, Farmington, CT 06030; and
Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104
The CD8 T cell response to vesicular stomatitis virus infection was
characterized in the spleen and intestinal mucosa using MHC tetramers.
Surprisingly, the primary response persisted in the lamina propria long
after the splenic response had declined. Furthermore, the response was
characterized by a protracted effector phase in which cytolytic
activity in the lamina propria, but not in the spleen, was maintained.
The appearance of Ag-specific cells in the intestinal mucosa was
largely, though not exclusively, a result of 
7
integrin-mediated migration. Infection with Listeria
monocytogenes or with vaccinia virus also led to sustained
mucosal responses. After reinfection of vesicular stomatitis
virus-primed mice with a serotypically distinct virus, a sustained
recall response was detected in all tissues. In CD40-/-
mice, the mucosal, but not the splenic, response was compromised,
resulting in diminished mucosal memory. The recall response was CD40
independent and correlated with memory levels, indicating that the
mucosal and systemic responses operated independently. These findings
illustrated the integrated yet distinct nature of systemic vs mucosal
immune responses.
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