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CUTTING EDGE |
Divisions of
*
General Internal Medicine and
Gastroenterology and Hepatology, Department of Internal Medicine, University of Innsbruck, Innsbruck, Austria
Dendritic cells (DC) are highly motile and play a key role in
mediating immune responses in various tissues and lymphatic organs. We
investigated locomotion of mononuclear cell-derived DC at different
maturation stages toward gradients of sensory neuropeptides in vitro.
Calcitonin gene-related peptide, vasoactive intestinal polypeptide,
secretin, and secretoneurin induced immature DC chemotaxis comparable
to the potency of RANTES, whereas substance P and
macrophage-inflammatory protein-3
stimulated immature cell migration
only slightly. Checkerboard analyses revealed a true chemotactic
response induced by neuropeptides. Upon maturation of DC, neuropeptides
inhibited spontaneous, macrophage-inflammatory protein-3- and
6Ckine-induced cell migration. Maturation-dependent changes in
migratory behavior coincided with distinct neuropeptide-induced signal
transduction in DC. Peripheral neuropeptides might guide immature DC to
peripheral nerve fibers where high concentrations of these peptides can
arrest the meanwhile matured cells. It seems that one function of
sensory nerves is to fasten DC at sites of
inflammation.
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