| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
,
,,
*
Departments of Neurology and
Immunology, Juntendo University School of Medicine, Tokyo, Japan;
Core Research for Evolutional Science and Technology of Japan Science and Technology Corp., Tokyo, Japan;
Department of Joint Disease and Rheumatism, Nippon Medical School, Tokyo, Japan;
¶ Third Department of Medicine (Neurology), Shinshu University School of Medicine, Matsumoto, Japan; and
||
Department of Surgery, Faculty of Medicine, University of Tokyo, Tokyo, Japan
OX40 (CD134) and its ligand (OX40L) have been implicated in T cell
activation and migration. In this study, we examined the contribution
of these molecules to the pathogenesis of experimental autoimmune
encephalomyelitis (EAE) by administering a neutralizing mAb against
murine OX40L (RM134L) to proteolipid protein (139–151) peptide-induced
EAE in SJL mice. Administration of RM134L effectively ameliorated the
disease in both actively induced and adoptively transferred EAE models.
Histological examination showed that the RM134L treatment greatly
reduced mononuclear cell infiltration into the spinal cord. The RM134L
treatment did not inhibit the development of pathogenic T cells, given
that proliferative response and IFN-
production by draining lymph
node cells were not reduced or rather enhanced upon restimulation with
proteolipid protein (139–151) in vitro, and these cells effectively
transferred EAE to naive SJL mice. Flow cytometric analyses showed that
the RM134L treatment inhibited the accumulation of OX40-expressing
CD4+ T cells and the migration of adoptively transferred
CD4+ T cells in the spinal cord. Immunohistochemical
staining showed that OX40L was most prominently expressed on
endothelial cells in the inflamed spinal cord. These results suggest
that the OX40/OX40L interaction plays a critical role for the migration
of pathogenic T cells into the CNS in the pathogenesis of
EAE.
This article has been cited by other articles:
|
|
 |
|
  W. L. Redmond, M. J. Gough, B. Charbonneau, T. L. Ratliff, and A. D. Weinberg Defects in the Acquisition of CD8 T Cell Effector Function after Priming with Tumor or Soluble Antigen Can Be Overcome by the Addition of an OX40 Agonist J. Immunol., December 1, 2007; 179(11): 7244 - 7253. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. J. Lepisto, M. Xu, H. Yagita, A. D. Weinberg, and R. L. Hendricks Expression and function of the OX40/OX40L costimulatory pair during herpes stromal keratitis J. Leukoc. Biol., March 1, 2007; 81(3): 766 - 774. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. J.A van Wanrooij, G. H.M van Puijvelde, P. de Vos, H. Yagita, T. J.C. van Berkel, and J. Kuiper Interruption of the Tnfrsf4/Tnfsf4 (OX40/OX40L) Pathway Attenuates Atherogenesis in Low-Density Lipoprotein Receptor-Deficient Mice Arterioscler Thromb Vasc Biol, January 1, 2007; 27(1): 204 - 210. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Aktas, T. Prozorovski, and F. Zipp Death Ligands and Autoimmune Demyelination Neuroscientist, August 1, 2006; 12(4): 305 - 316. [Abstract] [PDF]
|
|
|
|
|
|
J. R. Maxwell, R. Yadav, R. J. Rossi, C. E. Ruby, A. D. Weinberg, H. L. Aguila, and A. T. Vella IL-18 Bridges Innate and Adaptive Immunity through IFN-{gamma} and the CD134 Pathway J. Immunol., July 1, 2006; 177(1): 234 - 245. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Salek-Ardakani, T. So, B. S. Halteman, A. Altman, and M. Croft Protein Kinase C{theta} Controls Th1 Cells in Experimental Autoimmune Encephalomyelitis J. Immunol., December 1, 2005; 175(11): 7635 - 7641. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. S. Schmidt, J. Zhao, J. Chain, D. Hepburn, B. Gitter, G. Sandusky, S. Chintalacharuvu, A. Glasebrook, and S. Na Resistance to Myelin Oligodendrocyte Glycoprotein-Induced Experimental Autoimmune Encephalomyelitis by Death Receptor 6-Deficient Mice J. Immunol., August 15, 2005; 175(4): 2286 - 2292. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Mestas, S. P. Crampton, T. Hori, and C. C. W. Hughes Endothelial cell co-stimulation through OX40 augments and prolongs T cell cytokine synthesis by stabilization of cytokine mRNA Int. Immunol., June 1, 2005; 17(6): 737 - 747. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Florido, M. Borges, H. Yagita, and R. Appelberg Contribution of CD30/CD153 but not of CD27/CD70, CD134/OX40L, or CD137/4-1BBL to the optimal induction of protective immunity to Mycobacterium avium J. Leukoc. Biol., November 1, 2004; 76(5): 1039 - 1046. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. D. Weinberg, D. E. Evans, C. Thalhofer, T. Shi, and R. A. Prell The generation of T cell memory: a review describing the molecular and cellular events following OX40 (CD134) engagement J. Leukoc. Biol., June 1, 2004; 75(6): 962 - 972. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. A. Stephens, A. N. Barclay, and D. Mason Phenotypic characterization of regulatory CD4+CD25+ T cells in rats Int. Immunol., February 1, 2004; 16(2): 365 - 375. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Martin-Orozco, Z. Chen, L. Poirot, E. Hyatt, A. Chen, O. Kanagawa, A. Sharpe, D. Mathis, and C. Benoist Paradoxical Dampening of Anti-Islet Self-Reactivity but Promotion of Diabetes by OX40 Ligand J. Immunol., December 15, 2003; 171(12): 6954 - 6960. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Salek-Ardakani, J. Song, B. S. Halteman, A. G.-H. Jember, H. Akiba, H. Yagita, and M. Croft OX40 (CD134) Controls Memory T Helper 2 Cells that Drive Lung Inflammation J. Exp. Med., July 21, 2003; 198(2): 315 - 324. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Totsuka, T. Kanai, K. Uraushihara, R. Iiyama, M. Yamazaki, H. Akiba, H. Yagita, K. Okumura, and M. Watanabe Therapeutic effect of anti-OX40L and anti-TNF-alpha MAbs in a murine model of chronic colitis Am J Physiol Gastrointest Liver Physiol, April 1, 2003; 284(4): G595 - G603. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Yuan, A. D. Salama, V. Dong, I. Schmitt, N. Najafian, A. Chandraker, H. Akiba, H. Yagita, and M. H. Sayegh The Role of the CD134-CD134 Ligand Costimulatory Pathway in Alloimmune Responses In Vivo J. Immunol., March 15, 2003; 170(6): 2949 - 2955. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Taylor, M. Bachler, I. Duncan, S. Keen, R. Fallon, C. Mair, T. T. McDonald, and H. Schwarz In vitro and in vivo activities of OX40 (CD134)-IgG fusion protein isoforms with different levels of immune-effector functions J. Leukoc. Biol., September 1, 2002; 72(3): 522 - 529. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Yamada, A. D. Salama, and M. H. Sayegh The Role of Novel T Cell Costimulatory Pathways in Autoimmunity and Transplantation J. Am. Soc. Nephrol., February 1, 2002; 13(2): 559 - 575. [Full Text] [PDF]
|
|
|
|
|
|
L. C. Ndhlovu, N. Ishii, K. Murata, T. Sato, and K. Sugamura Critical Involvement of OX40 Ligand Signals in the T Cell Priming Events During Experimental Autoimmune Encephalomyelitis J. Immunol., September 1, 2001; 167(5): 2991 - 2999. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
