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*
Department of Respiratory Medicine,
Molecular Preventive Medicine, and Core Research for Evolutional Science and Technology, School of Medicine, University of Tokyo, Tokyo, Japan;
Second Department of Physiology, Showa University School of Medicine, Tokyo, Japan; and
Department of Bacteriology, Kinki University School of Medicine, Osaka, Japan
Thymus- and activation-regulated chemokine (TARC; CCL17) is a lymphocyte-directed CC chemokine that specifically chemoattracts CC chemokine receptor 4-positive (CCR4+) Th2 cells. To establish the pathophysiological roles of TARC in vivo, we investigated here whether an mAb against TARC could inhibit the induction of asthmatic reaction in mice elicited by OVA. TARC was constitutively expressed in the lung and was up-regulated in allergic inflammation. The specific Ab against TARC attenuated OVA-induced airway eosinophilia and diminished the degree of airway hyperresponsiveness with a concomitant decrease in Th2 cytokine levels. Our results for the first time indicate that TARC is a pivotal chemokine for the development of Th2-dominated experimental allergen-induced asthma with eosinophilia and AHR. This study also represents the first success in controlling Th2 cytokine production in vivo by targeting a chemokine.
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B. Bishop and C. M. Lloyd CC Chemokine Ligand 1 Promotes Recruitment of Eosinophils But Not Th2 Cells During the Development of Allergic Airways Disease J. Immunol., May 1, 2003; 170(9): 4810 - 4817. [Abstract] [Full Text] [PDF]
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 T.F. Leung, C.K. Wong, C.W.K. Lam, A.M. Li, W.K. Ip, G.W.K. Wong, and T.F. Fok Plasma TARC concentration may be a useful marker for asthmatic exacerbation in children Eur. Respir. J., April 1, 2003; 21(4): 616 - 620. [Abstract] [Full Text] [PDF]
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I. Goya, R. Villares, A. Zaballos, J. Gutierrez, L. Kremer, J.-A. Gonzalo, R. Varona, L. Carramolino, A. Serrano, P. Pallares, et al. Absence of CCR8 Does Not Impair the Response to Ovalbumin-Induced Allergic Airway Disease J. Immunol., February 15, 2003; 170(4): 2138 - 2146. [Abstract] [Full Text] [PDF]
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C. D. Chung, F. Kuo, J. Kumer, A. S. Motani, C. E. Lawrence, W. R. Henderson Jr., and C. Venkataraman CCR8 Is Not Essential for the Development of Inflammation in a Mouse Model of Allergic Airway Disease J. Immunol., January 1, 2003; 170(1): 581 - 587. [Abstract] [Full Text] [PDF]
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G. Cheng, M. Arima, K. Honda, H. Hirata, F. Eda, N. Yoshida, F. Fukushima, Y. Ishii, and T. Fukuda Anti-Interleukin-9 Antibody Treatment Inhibits Airway Inflammation and Hyperreactivity in Mouse Asthma Model Am. J. Respir. Crit. Care Med., August 1, 2002; 166(3): 409 - 416. [Abstract] [Full Text] [PDF]
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T. Horikawa, T. Nakayama, I. Hikita, H. Yamada, R. Fujisawa, T. Bito, S. Harada, A. Fukunaga, D. Chantry, P. W. Gray, et al. IFN-{gamma}-inducible expression of thymus and activation-regulated chemokine/CCL17 and macrophage-derived chemokine/CCL22 in epidermal keratinocytes and their roles in atopic dermatitis Int. Immunol., July 1, 2002; 14(7): 767 - 773. [Abstract] [Full Text] [PDF]
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E. Miyazaki, S.-i. Nureki, T. Fukami, T. Shigenaga, M. Ando, K. Ito, H. Ando, K. Sugisaki, T. Kumamoto, and T. Tsuda Elevated Levels of Thymus- and Activation-regulated Chemokine in Bronchoalveolar Lavage Fluid from Patients with Eosinophilic Pneumonia Am. J. Respir. Crit. Care Med., April 15, 2002; 165(8): 1125 - 1131. [Abstract] [Full Text] [PDF]
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