HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Xia, G. Articles by Waer, M. Search for Related Content PubMed PubMed Citation Articles by Xia, G. Articles by Waer, M.

Transplantation Tolerance and Autoimmunity After Xenogeneic Thymus Transplantation¹

Laboratory for Experimental Transplantation, University of Leuven, Leuven, Belgium

Successful grafting of vascularized xenografts (Xgs) depends on the ability to reliably induce both T cell-independent and -dependent immune tolerance. After temporary NK cell depletion, B cell suppression, and pretransplant infusion of donor Ags, athymic rats simultaneously transplanted with hamster heart and thymus Xgs developed immunocompetent rat-derived T cells that tolerated the hamster Xgs but provoked multiple-organ autoimmunity. The autoimmune syndrome was probably due to an insufficient development of tolerance for some rat organs; for example, it led to thyroiditis in the recipient rat thyroid, but not in simultaneously transplanted donor hamster thyroid. Moreover, grafting a mixed hamster/rat thymic epithelial cell graft could prevent the autoimmune syndrome. These experiments indicate that host-type thymic epithelial cells may be essential for the establishment of complete self-tolerance and that mixed host/donor thymus grafts may induce T cell xenotolerance while maintaining self-tolerance in the recipient.

This article has been cited by other articles:

				Y. Fudaba, T. Onoe, M. Chittenden, A. Shimizu, J. M. Shaffer, R. Bronson, and M. Sykes Abnormal Regulatory and Effector T Cell Function Predispose to Autoimmunity following Xenogeneic Thymic Transplantation J. Immunol., December 1, 2008; 181(11): 7649 - 7659. [Abstract] [Full Text] [PDF]

				S. Li, Y. Yan, Y. Lin, D. M. Bullens, O. Rutgeerts, J. Goebels, C. Segers, L. Boon, A. Kasran, R. De Vos, et al. Rapidly induced, T-cell independent xenoantibody production is mediated by marginal zone B cells and requires help from NK cells Blood, December 1, 2007; 110(12): 3926 - 3935. [Abstract] [Full Text] [PDF]

				P. Lan, N. Tonomura, A. Shimizu, S. Wang, and Y.-G. Yang Reconstitution of a functional human immune system in immunodeficient mice through combined human fetal thymus/liver and CD34+ cell transplantation Blood, July 15, 2006; 108(2): 487 - 492. [Abstract] [Full Text] [PDF]

				Y. Yan, T. Devos, L. Yu, G. Xia, O. Rutgeerts, J. Goebels, C. Segers, Y. Lin, M. Vandeputte, and M. Waer Pathogenesis of Autoimmunity After Xenogeneic Thymus Transplantation J. Immunol., June 15, 2003; 170(12): 5936 - 5946. [Abstract] [Full Text] [PDF]