The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Blease, K.
Right arrow Articles by Hogaboam, C. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Blease, K.
Right arrow Articles by Hogaboam, C. M.
The Journal of Immunology, 2001, 166: 1832-1842.
Copyright © 2001 by The American Association of Immunologists

Antifungal and Airway Remodeling Roles for Murine Monocyte Chemoattractant Protein-1/CCL2 During Pulmonary Exposure to Asperigillus fumigatus Conidia1

Kate Blease*, Borna Mehrad{dagger}, Nicholas W. Lukacs*, Steven L. Kunkel*, Theodore J. Standiford{dagger} and Cory M. Hogaboam2,*

* Departments of Pathology and {dagger} Internal Medicine, Division of Pulmonary and Critical Care, University of Michigan Medical School, Ann Arbor, MI 48109

Asperigillus fumigatus spores or conidia are quickly eliminated from the airways of nonsensitized individuals but persist in individuals with allergic pulmonary responsiveness to fungus. A. fumigatus-induced allergic airway disease is characterized by persistent airway hyperreactivity, inflammation, and fibrosis. The present study explored the role of CCR2 ligands in the murine airway response to A. fumigatus conidia. Nonsensitized and A. fumigatus-sensitized CBA/J mice received an intratracheal challenge of A. fumigatus conidia, and pulmonary changes were analyzed at various times after conidia. Whole lung levels of monocyte chemoattractant protein-1 (MCP-1/CCL2), but neither MCP-3/CCL7 nor MCP-5/CCL12, were significantly elevated at days 3 and 7 after conidia in nonsensitized mice. MCP-1/CCL2 was significantly increased in lung samples from A. fumigatus-sensitized mice at days 14 and 30 after a conidia challenge. Administration of anti-MCP-1/CCL2 antiserum to nonsensitized mice for14 days after the conidia challenge attenuated the clearance of conidia and significantly increased airway hyperreactivity, eosinophilia, and peribronchial fibrosis compared with nonsensitized mice that received conidia and normal serum. Adenovirus-directed overexpression of MCP-1/CCL2 in A. fumigatus-sensitized mice markedly reduced the number of conidia, airway inflammation, and airway hyperresponsiveness at day 7 after the conidia challenge in these mice. Immunoneutralization of MCP-1/CCL2 levels in A. fumigatus-sensitized mice during days14–30 after the conidia challenge did not affect the conidia burden but significantly reduced airway hyperreactivity, lung IL-4 levels, and lymphocyte recruitment into the airways compared with the control group. These data suggest that MCP-1/CCL2 participates in the pulmonary antifungal and allergic responses to A. fumigatus conidia.




This article has been cited by other articles:


Home page
 Clin. Microbiol. Rev.Home page
S. J. Park and B. Mehrad
Innate Immunity to Aspergillus Species
Clin. Microbiol. Rev., October 1, 2009; 22(4): 535 - 551.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
X. Li, C. Hanson, J. L. Cmarik, and S. Ruscetti
Neurodegeneration Induced by PVC-211 Murine Leukemia Virus Is Associated with Increased Levels of Vascular Endothelial Growth Factor and Macrophage Inflammatory Protein 1{alpha} and Is Inhibited by Blocking Activation of Microglia
J. Virol., May 15, 2009; 83(10): 4912 - 4922.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
H. Ramaprakash, T. Ito, T. J. Standiford, S. L. Kunkel, and C. M. Hogaboam
Toll-Like Receptor 9 Modulates Immune Responses to Aspergillus fumigatus Conidia in Immunodeficient and Allergic Mice
Infect. Immun., January 1, 2009; 77(1): 108 - 119.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
F. Hildebrand, W. J. Hubbard, M. A. Choudhry, M. Frink, H.-C. Pape, S. L. Kunkel, and I. H. Chaudry
Kupffer Cells and Their Mediators: The Culprits in Producing Distant Organ Damage after Trauma-Hemorrhage
Am. J. Pathol., September 1, 2006; 169(3): 784 - 794.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
D. W. Denning, B. R. O'Driscoll, C. M. Hogaboam, P. Bowyer, and R. M. Niven
The link between fungi and severe asthma: a summary of the evidence.
Eur. Respir. J., March 1, 2006; 27(3): 615 - 626.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
C. M. Hogaboam, K. Takahashi, R. A. B. Ezekowitz, S. L. Kunkel, and J. M. Schuh
Mannose-binding lectin deficiency alters the development of fungal asthma: effects on airway response, inflammation, and cytokine profile
J. Leukoc. Biol., May 1, 2004; 75(5): 805 - 814.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
G. C. Hildebrandt, U. A. Duffner, K. M. Olkiewicz, L. A. Corrion, N. E. Willmarth, D. L. Williams, S. G. Clouthier, C. M. Hogaboam, P. R. Reddy, B. B. Moore, et al.
A critical role for CCR2/MCP-1 interactions in the development of idiopathic pneumonia syndrome after allogeneic bone marrow transplantation
Blood, March 15, 2004; 103(6): 2417 - 2426.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
A. Panoskaltsis-Mortari, J. R. Hermanson, E. Taras, O. D. Wangensteen, I. F. Charo, B. J. Rollins, and B. R. Blazar
Post-BMT lung injury occurs independently of the expression of CCL2 or its receptor, CCR2, on host cells
Am J Physiol Lung Cell Mol Physiol, February 1, 2004; 286(2): L284 - L292.
[Abstract] [Full Text] [PDF]

Home page
 J Antimicrob ChemotherHome page
M. J. Becker, S. de Marie, M. H. A. M. Fens, H. A. Verbrugh, and I. A. J. M. Bakker-Woudenberg
Effect of amphotericin B treatment on kinetics of cytokines and parameters of fungal load in neutropenic rats with invasive pulmonary aspergillosis
J. Antimicrob. Chemother., September 1, 2003; 52(3): 428 - 434.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. N. Ajuebor, C. M. Hogaboam, T. Le, and M. G. Swain
C-C Chemokine Ligand 2/Monocyte Chemoattractant Protein-1 Directly Inhibits NKT Cell IL-4 Production and Is Hepatoprotective in T Cell-Mediated Hepatitis in the Mouse
J. Immunol., May 15, 2003; 170(10): 5252 - 5259.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
J. M. Schuh, K. Blease, S. L. Kunkel, and C. M. Hogaboam
Eotaxin/CCL11 is involved in acute, but not chronic, allergic airway responses to Aspergillus fumigatus
Am J Physiol Lung Cell Mol Physiol, July 1, 2002; 283(1): L198 - L204.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. S. Cheng, N. W. Lukacs, and S. L. Kunkel
Eotaxin/CCL11 Suppresses IL-8/CXCL8 Secretion from Human Dermal Microvascular Endothelial Cells
J. Immunol., March 15, 2002; 168(6): 2887 - 2894.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. M. Schuh, K. Blease, and C. M. Hogaboam
CXCR2 Is Necessary for the Development and Persistence of Chronic Fungal Asthma in Mice
J. Immunol., February 1, 2002; 168(3): 1447 - 1456.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
K. Blease, C. Jakubzick, J. M. Schuh, B. H. Joshi, R. K. Puri, and C. M. Hogaboam
IL-13 Fusion Cytotoxin Ameliorates Chronic Fungal-Induced Allergic Airway Disease in Mice
J. Immunol., December 1, 2001; 167(11): 6583 - 6592.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 2001 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 2001 by The American Association of Immunologists, Inc. All rights reserved.