| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
*
Department of Microbiology, University of Western Australia and the Western Australian Institute for Medical Research, Nedlands, Western Australia, Australia; and
Division of Virology, Animal Health Trust, Kentford, Suffolk, United Kingdom
NK cells mediate early host defense against viral infection. In murine CMV (MCMV) infection NK cells play a critical role in controlling viral replication in target organs, such as spleen and liver. Until now it has not been possible to directly examine the role of NK cells in MCMV-induced inflammation in situ due to the inability to stain specifically for NK cells in infected tissues. In this study, we describe a method of in vivo fixation, resulting in the first identification of NK cells in situ using NK1.1 as the marker. Using this method, we characterize the NK1.1+ cellular component of the inflammatory response to wild-type MCMV in the spleen, liver, and lung of genetically susceptible and resistant mice following i.p. infection. This study provides the first in situ description of the cellular response mediated specifically by NK cells following MCMV infection.
This article has been cited by other articles:
|
|
 |
|
  N. Fodil-Cornu, S.-H. Lee, S. Belanger, A. P. Makrigiannis, C. A. Biron, R. M. Buller, and S. M. Vidal Ly49h-Deficient C57BL/6 Mice: A New Mouse Cytomegalovirus-Susceptible Model Remains Resistant to Unrelated Pathogens Controlled by the NK Gene Complex J. Immunol., November 1, 2008; 181(9): 6394 - 6405. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Walzer, M. Blery, J. Chaix, N. Fuseri, L. Chasson, S. H. Robbins, S. Jaeger, P. Andre, L. Gauthier, L. Daniel, et al. Identification, activation, and selective in vivo ablation of mouse NK cells via NKp46 PNAS, February 27, 2007; 104(9): 3384 - 3389. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Roland, V. Soulard, C. Sellier, A.-M. Drapier, J. P. Di Santo, P.-A. Cazenave, and S. Pied NK Cell Responses to Plasmodium Infection and Control of Intrahepatic Parasite Development J. Immunol., July 15, 2006; 177(2): 1229 - 1239. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Bajenoff, B. Breart, A. Y.C. Huang, H. Qi, J. Cazareth, V. M. Braud, R. N. Germain, and N. Glaichenhaus Natural killer cell behavior in lymph nodes revealed by static and real-time imaging J. Exp. Med., March 20, 2006; 203(3): 619 - 631. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A.-C. Iversen, P. S. Norris, C. F. Ware, and C. A. Benedict Human NK Cells Inhibit Cytomegalovirus Replication through a Noncytolytic Mechanism Involving Lymphotoxin-Dependent Induction of IFN-{beta} J. Immunol., December 1, 2005; 175(11): 7568 - 7574. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. E. Berg, E. Crossley, S. Murray, and J. Forman Relative Contributions of NK and CD8 T Cells to IFN-{gamma} Mediated Innate Immune Protection against Listeria monocytogenes J. Immunol., August 1, 2005; 175(3): 1751 - 1757. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. J. Redwood, M. Messerle, N. L. Harvey, C. M. Hardy, U. H. Koszinowski, M. A. Lawson, and G. R. Shellam Use of a Murine Cytomegalovirus K181-Derived Bacterial Artificial Chromosome as a Vaccine Vector for Immunocontraception J. Virol., March 1, 2005; 79(5): 2998 - 3008. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Yuan, R. Bibi, and T. Dang The role of adjuvant on the regulatory effects of NK cells on B cell responses as revealed by a new model of NK cell deficiency Int. Immunol., May 1, 2004; 16(5): 707 - 716. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. G. Dorner, H. R.C. Smith, A. R. French, S. Kim, J. Poursine-Laurent, D. L. Beckman, J. T. Pingel, R. A. Kroczek, and W. M. Yokoyama Coordinate Expression of Cytokines and Chemokines by NK Cells during Murine Cytomegalovirus Infection J. Immunol., March 1, 2004; 172(5): 3119 - 3131. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. J. Cavanaugh, Y. Deng, M. P. Birkenbach, J. S. Slater, and A. E. Campbell Vigorous Innate and Virus-Specific Cytotoxic T-Lymphocyte Responses to Murine Cytomegalovirus in the Submaxillary Salivary Gland J. Virol., February 1, 2003; 77(3): 1703 - 1717. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. W. McVicar, R. Winkler-Pickett, L. S. Taylor, A. Makrigiannis, M. Bennett, S. K. Anderson, and J. R. Ortaldo Aberrant DAP12 Signaling in the 129 Strain of Mice: Implications for the Analysis of Gene-Targeted Mice J. Immunol., August 15, 2002; 169(4): 1721 - 1728. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. O. Dokun, D. T. Chu, L. Yang, A. S. Bendelac, and W. M. Yokoyama Analysis of In Situ NK Cell Responses During Viral Infection J. Immunol., November 1, 2001; 167(9): 5286 - 5293. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
