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The Journal of Immunology, 2001, 166: 1659-1666.
Copyright © 2001 by The American Association of Immunologists

Chemokine Receptor Expressions and Responsiveness of Cord Blood T Cells

Katsuaki Sato*, Hiroshi Kawasaki{dagger}, Hitomi Nagayama*, Makoto Enomoto*, Chikao Morimoto{dagger}, Kenji Tadokoro{ddagger}, Takeo Juji{ddagger} and Tsuneo A. Takahashi1,*

Departments of * Cell Processing and {dagger} Clinical Immunology and AIDS Research Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan; and {ddagger} Japanese Red Cross Central Blood Center, Tokyo, Japan

Chemokines and their receptors play a critical role in the selective attraction of various subsets of leukocytes. We examined the chemokine receptor expressions and responsiveness of cord blood (CB) T cells. Flow-cytometric analysis revealed that peripheral blood (PB) T cells expressed CCR-1, CCR-2, CCR-5, CCR-6, CXC chemokine receptor-3 (CXCR-3), and CXCR-4, while CB T cells expressed only CXCR-4 on their surface. Chemotactic migratory response of CB T cells to macrophage-inflammatory protein (MIP)-1{alpha}, monocyte chemoattractant protein-1, RANTES, MIP-3{alpha}, monokine induced by IFN-{gamma}, and IFN-{gamma}-inducible protein-10 was significantly impaired compared with those of PB T cells. In contrast, the ability of CB T cells to migrate to MIP-3{beta}, 6Ckine, and stromal cell-derived factor-1{alpha} was greater than that of PB T cells, and these events were correlated with the expression levels of CCR-7 and CXCR-4, respectively. Engagement of CD3 and CD28 specifically up-regulated CXCR-3 expression and chemotaxis to monokine induced by IFN-{gamma} and IFN-{gamma}-inducible protein-10, whereas this stimulation down-regulated CCR-7 expression and chemotaxis to MIP-3{beta} and 6Ckine in PB T cells, but not in CB T cells. These results suggest that PB T cells and CB T cells exhibit distinct chemokine responsiveness via different chemokine receptor repertoire.




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