| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
*
Rheumatology/Immunology and Allergy, Department of Medicine, Tri-Service General Hospital;
Graduate Institute of Life Science;
Institute of Biology and Anatomy; and
Department of Parasitology and Tropical Medicine, National Defense Medical Center, Taiwan, Republic of China;
¶ School of Medical Technology, College of Medicine and Division of Infectious Disease, National Taiwan University, Taiwan, Republic of China; and
||
Immunology Division, Cheng-Hsin Rehabilitation Medical Center, Taiwan, Republic of China.
Dengue virus (DV) infection is a major problem in public health. It
can cause fatal diseases such as Dengue hemorrhagic fever and Dengue
shock syndrome. Dendritic cells (DC) are professional APCs required for
establishing a primary immune response. Here, we investigated the role
of human PBMC-derived DC in DV infection. Using different techniques,
including plaque assay, flow cytometry analysis, nested RT-PCR, and
confocal microscope and electron microscope examinations, we show that
DV can enter cultured human DC and produce virus particles. After
entrance, DV could be visualized in cystic vesicles, vacuoles, and the
endoplasmic reticulum. The DV-infected DC also showed proliferation and
hypertrophy of the endoplasmic reticulum as well as the swollen
mitochondria. In addition, the DV-stimulated DC could express
maturation markers such as B7-1, B7-2, HLA-DR, CD11b, and CD83.
Furthermore, the infection of DC by DV induced production of TNF-
and IFN-, but not IL-6 and IL-12. Although DC underwent spontaneous
apoptosis in the absence of feeding cytokines, this process appeared to
be delayed after DV infection. Our observations provide important
information in understanding the pathogenesis of DV
infection.
This article has been cited by other articles:
|
|
 |
|
  B. E. E. Martina, P. Koraka, and A. D. M. E. Osterhaus Dengue Virus Pathogenesis: an Integrated View Clin. Microbiol. Rev., October 1, 2009; 22(4): 564 - 581. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y.-W. Lin, S.-W. Wang, Y.-Y. Tung, and S.-H. Chen Enterovirus 71 Infection of Human Dendritic Cells Experimental Biology and Medicine, October 1, 2009; 234(10): 1166 - 1173. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Kamau, R. Takhampunya, T. Li, E. Kelly, K. K. Peachman, J. A. Lynch, P. Sun, and D. R. Palmer Dengue virus infection promotes translocation of high mobility group box 1 protein from the nucleus to the cytosol in dendritic cells, upregulates cytokine production and modulates virus replication J. Gen. Virol., August 1, 2009; 90(8): 1827 - 1835. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Ikeda, T. Kojima, S. Kuroda, Y. Endo, R. Sakai, M. Hioki, H. Kishimoto, F. Uno, S. Kagawa, Y. Watanabe, et al. A Novel Antiangiogenic Effect for Telomerase-Specific Virotherapy through Host Immune System J. Immunol., February 1, 2009; 182(3): 1763 - 1769. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-J. Cheng, C.-F. Lin, H.-Y. Lei, H.-S. Liu, T.-M. Yeh, Y.-H. Luo, and Y.-S. Lin Proteomic Analysis of Endothelial Cell Autoantigens Recognized by Anti-Dengue Virus Nonstructural Protein 1 Antibodies Experimental Biology and Medicine, January 1, 2009; 234(1): 63 - 73. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. D. Nightingale, C. Patkar, and A. L. Rothman Viral replication and paracrine effects result in distinct, functional responses of dendritic cells following infection with dengue 2 virus J. Leukoc. Biol., October 1, 2008; 84(4): 1028 - 1038. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. O. Weinzierl, G. Szalay, H. Wolburg, M. Sauter, H.-G. Rammensee, R. Kandolf, S. Stevanovic, and K. Klingel Effective Chemokine Secretion by Dendritic Cells and Expansion of Cross-Presenting CD4-/CD8+ Dendritic Cells Define a Protective Phenotype in the Mouse Model of Coxsackievirus Myocarditis J. Virol., August 15, 2008; 82(16): 8149 - 8160. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Boonnak, B. M. Slike, T. H. Burgess, R. M. Mason, S.-J. Wu, P. Sun, K. Porter, I. F. Rudiman, D. Yuwono, P. Puthavathana, et al. Role of Dendritic Cells in Antibody-Dependent Enhancement of Dengue Virus Infection J. Virol., April 15, 2008; 82(8): 3939 - 3951. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. C. Silva, A. Guerrero-Plata, F. D. Gilfoy, R. P. Garofalo, and P. W. Mason Differential Activation of Human Monocyte-Derived and Plasmacytoid Dendritic Cells by West Nile Virus Generated in Different Host Cells J. Virol., December 15, 2007; 81(24): 13640 - 13648. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Wati, P. Li, C. J. Burrell, and J. M. Carr Dengue Virus (DV) Replication in Monocyte-Derived Macrophages Is Not Affected by Tumor Necrosis Factor Alpha (TNF-{alpha}), and DV Infection Induces Altered Responsiveness to TNF-{alpha} Stimulation J. Virol., September 15, 2007; 81(18): 10161 - 10171. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. DEAUVIEAU, V. SANCHEZ, C. BALAS, A. KENNEL, A. DE MONTFORT, J. LANG, and B. GUY INNATE IMMUNE RESPONSES IN HUMAN DENDRITIC CELLS UPON INFECTION BY CHIMERIC YELLOW-FEVER DENGUE VACCINE SEROTYPES 1-4 Am J Trop Med Hyg, January 1, 2007; 76(1): 144 - 154. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. N. Harman, J. Wilkinson, C. R. Bye, L. Bosnjak, J. L. Stern, M. Nicholle, J. Lai, and A. L. Cunningham HIV Induces Maturation of Monocyte-Derived Dendritic Cells and Langerhans Cells J. Immunol., November 15, 2006; 177(10): 7103 - 7113. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Sun, C. M. Celluzzi, M. Marovich, H. Subramanian, M. Eller, S. Widjaja, D. Palmer, K. Porter, W. Sun, and T. Burgess CD40 Ligand Enhances Dengue Viral Infection of Dendritic Cells: A Possible Mechanism for T Cell-Mediated Immunopathology J. Immunol., November 1, 2006; 177(9): 6497 - 6503. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Shrestha, T. Wang, M. A. Samuel, K. Whitby, J. Craft, E. Fikrig, and M. S. Diamond Gamma Interferon Plays a Crucial Early Antiviral Role in Protection against West Nile Virus Infection. J. Virol., June 1, 2006; 80(11): 5338 - 5348. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Zhou and S. Perlman Preferential Infection of Mature Dendritic Cells by Mouse Hepatitis Virus Strain JHM J. Virol., March 1, 2006; 80(5): 2506 - 2514. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Shrestha, M. A. Samuel, and M. S. Diamond CD8+ T Cells Require Perforin To Clear West Nile Virus from Infected Neurons J. Virol., January 1, 2006; 80(1): 119 - 129. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. F. Narvaez, J. Angel, and M. A. Franco Interaction of Rotavirus with Human Myeloid Dendritic Cells J. Virol., December 1, 2005; 79(23): 14526 - 14535. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Shresta, K. L. Sharar, D. M. Prigozhin, H. M. Snider, P. R. Beatty, and E. Harris Critical Roles for Both STAT1-Dependent and STAT1-Independent Pathways in the Control of Primary Dengue Virus Infection in Mice J. Immunol., September 15, 2005; 175(6): 3946 - 3954. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. L. Medin, K. A. Fitzgerald, and A. L. Rothman Dengue Virus Nonstructural Protein NS5 Induces Interleukin-8 Transcription and Secretion J. Virol., September 1, 2005; 79(17): 11053 - 11061. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. R. Lambeth, L. J. White, R. E. Johnston, and A. M. de Silva Flow Cytometry-Based Assay for Titrating Dengue Virus J. Clin. Microbiol., July 1, 2005; 43(7): 3267 - 3272. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P.-Y. Lozach, L. Burleigh, I. Staropoli, E. Navarro-Sanchez, J. Harriague, J.-L. Virelizier, F. A. Rey, P. Despres, F. Arenzana-Seisdedos, and A. Amara Dendritic Cell-specific Intercellular Adhesion Molecule 3-grabbing Non-integrin (DC-SIGN)-mediated Enhancement of Dengue Virus Infection Is Independent of DC-SIGN Internalization Signals J. Biol. Chem., June 24, 2005; 280(25): 23698 - 23708. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W.-H. Kwan, A.-M. Helt, C. Maranon, J.-B. Barbaroux, A. Hosmalin, E. Harris, W. H. Fridman, and C. G. F. Mueller Dendritic Cell Precursors Are Permissive to Dengue Virus and Human Immunodeficiency Virus Infection J. Virol., June 15, 2005; 79(12): 7291 - 7299. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Mehlhop, K. Whitby, T. Oliphant, A. Marri, M. Engle, and M. S. Diamond Complement Activation Is Required for Induction of a Protective Antibody Response against West Nile Virus Infection J. Virol., June 15, 2005; 79(12): 7466 - 7477. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L.-J. Ho, L.-F. Hung, C.-Y. Weng, W.-L. Wu, P. Chou, Y.-L. Lin, D.-M. Chang, T.-Y. Tai, and J.-H. Lai Dengue Virus Type 2 Antagonizes IFN-{alpha} but Not IFN-{gamma} Antiviral Effect via Down-Regulating Tyk2-STAT Signaling in the Human Dendritic Cell J. Immunol., June 15, 2005; 174(12): 8163 - 8172. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. P. Ribeiro, A. M. Paradiso, U. Schwab, J. Perez-Vilar, L. Jones, W. O'Neal, and R. C. Boucher Chronic Airway Infection/Inflammation Induces a Ca2+i-dependent Hyperinflammatory Response in Human Cystic Fibrosis Airway Epithelia J. Biol. Chem., May 6, 2005; 280(18): 17798 - 17806. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. R. Palmer, P. Sun, C. Celluzzi, J. Bisbing, S. Pang, W. Sun, M. A. Marovich, and T. Burgess Differential Effects of Dengue Virus on Infected and Bystander Dendritic Cells J. Virol., February 15, 2005; 79(4): 2432 - 2439. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. BRANDLER, N. BROWN, T. H. ERMAK, F. MITCHELL, M. PARSONS, Z. ZHANG, J. LANG, T. P. MONATH, and F. GUIRAKHOO REPLICATION OF CHIMERIC YELLOW FEVER VIRUS-DENGUE SEROTYPE 1-4 VIRUS VACCINE STRAINS IN DENDRITIC AND HEPATIC CELLS Am J Trop Med Hyg, January 1, 2005; 72(1): 74 - 81. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-F. Lin, S.-C. Chiu, Y.-L. Hsiao, S.-W. Wan, H.-Y. Lei, A.-L. Shiau, H.-S. Liu, T.-M. Yeh, S.-H. Chen, C.-C. Liu, et al. Expression of Cytokine, Chemokine, and Adhesion Molecules during Endothelial Cell Activation Induced by Antibodies against Dengue Virus Nonstructural Protein 1 J. Immunol., January 1, 2005; 174(1): 395 - 403. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G N Malavige, S Fernando, D J Fernando, and S L Seneviratne Dengue viral infections Postgrad. Med. J., October 1, 2004; 80(948): 588 - 601. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Fantuzzi, C. Purificato, K. Donato, F. Belardelli, and S. Gessani Human Immunodeficiency Virus Type 1 gp120 Induces Abnormal Maturation and Functional Alterations of Dendritic Cells: a Novel Mechanism for AIDS Pathogenesis J. Virol., September 15, 2004; 78(18): 9763 - 9772. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Niiya, T. Azuma, L. Jin, N. Uchida, A. Inoue, H. Hasegawa, S. Fujita, M. Tohyama, K. Hashimoto, and M. Yasukawa Transcriptional downregulation of DC-SIGN in human herpesvirus 6-infected dendritic cells J. Gen. Virol., September 1, 2004; 85(9): 2639 - 2642. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R.-J. Lin, C.-L. Liao, E. Lin, and Y.-L. Lin Blocking of the Alpha Interferon-Induced Jak-Stat Signaling Pathway by Japanese Encephalitis Virus Infection J. Virol., September 1, 2004; 78(17): 9285 - 9294. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. P. Carrasco, R. C. Rigden, I. E. Vincent, C. Balmelli, M. Ceppi, O. Bauhofer, V. Tache, B. Hjertner, F. McNeilly, H. G. van Gennip, et al. Interaction of classical swine fever virus with dendritic cells J. Gen. Virol., June 1, 2004; 85(6): 1633 - 1641. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Granelli-Piperno, A. Golebiowska, C. Trumpfheller, F. P. Siegal, and R. M. Steinman HIV-1-infected monocyte-derived dendritic cells do not undergo maturation but can elicit IL-10 production and T cell regulation PNAS, May 18, 2004; 101(20): 7669 - 7674. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Shresta, J. L. Kyle, H. M. Snider, M. Basavapatna, P. R. Beatty, and E. Harris Interferon-Dependent Immunity Is Essential for Resistance to Primary Dengue Virus Infection in Mice, Whereas T- and B-Cell-Dependent Immunity Are Less Critical J. Virol., March 15, 2004; 78(6): 2701 - 2710. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-J. Hung, M.-T. Hsieh, M.-J. Young, C.-L. Kao, C.-C. King, and W. Chang An External Loop Region of Domain III of Dengue Virus Type 2 Envelope Protein Is Involved in Serotype-Specific Binding to Mosquito but Not Mammalian Cells J. Virol., January 1, 2004; 78(1): 378 - 388. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. E. Vincent, C. P. Carrasco, B. Herrmann, B. M. Meehan, G. M. Allan, A. Summerfield, and K. C. McCullough Dendritic Cells Harbor Infectious Porcine Circovirus Type 2 in the Absence of Apparent Cell Modulation or Replication of the Virus J. Virol., December 15, 2003; 77(24): 13288 - 13300. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. W. Geisbert, L. E. Hensley, T. Larsen, H. A. Young, D. S. Reed, J. B. Geisbert, D. P. Scott, E. Kagan, P. B. Jahrling, and K. J. Davis Pathogenesis of Ebola Hemorrhagic Fever in Cynomolgus Macaques: Evidence that Dendritic Cells Are Early and Sustained Targets of Infection Am. J. Pathol., December 1, 2003; 163(6): 2347 - 2370. [Abstract] [Full Text]
|
|
|
|
|
|
S. Pichyangkul, T. P. Endy, S. Kalayanarooj, A. Nisalak, K. Yongvanitchit, S. Green, A. L. Rothman, F. A. Ennis, and D. H. Libraty A Blunted Blood Plasmacytoid Dendritic Cell Response to an Acute Systemic Viral Infection Is Associated with Increased Disease Severity J. Immunol., November 15, 2003; 171(10): 5571 - 5578. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Tassaneetrithep, T. H. Burgess, A. Granelli-Piperno, C. Trumpfheller, J. Finke, W. Sun, M. A. Eller, K. Pattanapanyasat, S. Sarasombath, D. L. Birx, et al. DC-SIGN (CD209) Mediates Dengue Virus Infection of Human Dendritic Cells J. Exp. Med., April 7, 2003; 197(7): 823 - 829. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Cologna and R. Rico-Hesse American Genotype Structures Decrease Dengue Virus Output from Human Monocytes and Dendritic Cells J. Virol., April 1, 2003; 77(7): 3929 - 3938. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Mahanty, K. Hutchinson, S. Agarwal, M. Mcrae, P. E. Rollin, and B. Pulendran Cutting Edge: Impairment of Dendritic Cells and Adaptive Immunity by Ebola and Lassa Viruses J. Immunol., March 15, 2003; 170(6): 2797 - 2801. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.-W. Lin, K.-J. Wang, H.-Y. Lei, Y.-S. Lin, T.-M. Yeh, H.-S. Liu, C.-C. Liu, and S.-H. Chen Virus Replication and Cytokine Production in Dengue Virus-Infected Human B Lymphocytes J. Virol., October 25, 2002; 76(23): 12242 - 12249. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Raftery, A. A. Kraus, R. Ulrich, D. H. Kruger, and G. Schonrich Hantavirus Infection of Dendritic Cells J. Virol., October 2, 2002; 76(21): 10724 - 10733. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Kakimoto, A. Hasegawa, S. Fujita, and M. Yasukawa Phenotypic and Functional Alterations of Dendritic Cells Induced by Human Herpesvirus 6 Infection J. Virol., September 11, 2002; 76(20): 10338 - 10345. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Li, D. Liu, L. Hutt-Fletcher, A. Morgan, M. G. Masucci, and V. Levitsky Epstein-Barr virus inhibits the development of dendritic cells by promoting apoptosis of their monocyte precursors in the presence of granulocyte macrophage-colony-stimulating factor and interleukin-4 Blood, May 15, 2002; 99(10): 3725 - 3734. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. M. B. Moreno-Altamirano, F. J. Sanchez-Garcia, and M. L. Munoz Non Fc receptor-mediated infection of human macrophages by dengue virus serotype 2 J. Gen. Virol., May 1, 2002; 83(5): 1123 - 1130. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Anraku, T. J. Harvey, R. Linedale, J. Gardner, D. Harrich, A. Suhrbier, and A. A. Khromykh Kunjin Virus Replicon Vaccine Vectors Induce Protective CD8+ T-Cell Immunity J. Virol., March 19, 2002; 76(8): 3791 - 3799. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. F. Lipscomb and B. J. Masten Dendritic Cells: Immune Regulators in Health and Disease Physiol Rev, January 1, 2002; 82(1): 97 - 130. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
