The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Tang, C.
Right arrow Articles by O’Byrne, P. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Tang, C.
Right arrow Articles by O’Byrne, P. M.
The Journal of Immunology, 2001, 166: 1471-1481.
Copyright © 2001 by The American Association of Immunologists

Th Type 1-Stimulating Activity of Lung Macrophages Inhibits Th2-Mediated Allergic Airway Inflammation by an IFN-{gamma}-Dependent Mechanism1

Chibing Tang*, Mark D. Inman*, Nico van Rooijen{dagger}, Pingchang Yang*, Huahao Shen*, Koichiro Matsumoto* and Paul M. O’Byrne2,*

* Asthma Research Group, Department of Medicine, McMaster University, Hamilton, Ontario, Canada; and {dagger} Department of Cell Biology and Immunology Faculty of Medicine, Vrije University, Amsterdam, The Netherlands

In the mucosal immune system, resident dendritic cells are specialized for priming Th2-polarized immunity, whereas the Ag-presenting activity of macrophages has been linked with the development of Th1 phenotype. As an immune switch toward Th1 can protect against Th2-mediated allergic response, this study investigated the capacity of lung macrophages to stimulate Th1 responses during the secondary exposure to inhaled allergen, thereby suppressing Th2-mediated allergic airway inflammation in a murine model of allergic asthma. Following airway macrophage depletion in OVA-sensitized mice, lung T cells defaulted to a phenotype that produced less Th1 (IFN-{gamma}) and more Th2 (IL-4 and IL-5) cytokines, leading to more severe airway hyperreactivity and inflammation after intranasal Ag challenge. After OVA pulsing and adoptive transfer, lung macrophages selectively promoted a Th1 response in Ag-sensitized recipients and did not induce pulmonary eosinophilia. By contrast, OVA pulsing and adoptive transfer of a lung cell preparation, consisting of dendritic cells, B cells, and macrophages, promoted a Th2 response with an associated inflammatory response that was suppressed when macrophages were present and pretreated with IFN-{gamma}, but exacerbated when macrophages were depleted before IFN-{gamma} treatment. In addition, Th1-promoting activity of lung macrophages was not related to the autocrine production of IL-12p40. These results suggest that the Th1-promoting APC activity may be an inherent property of the lung macrophage population, and may play an important role, upon stimulation by IFN-{gamma}, in antagonizing an ongoing Th2 immunity and Th2-dependent allergic responses.




This article has been cited by other articles:


Home page
 Int ImmunolHome page
K.-a. Moon, S. Y. Kim, T.-B. Kim, E. S. Yun, C.-S. Park, Y. S. Cho, H.-B. Moon, and K.-Y. Lee
Allergen-induced CD11b+ CD11cint CCR3+ macrophages in the lung promote eosinophilic airway inflammation in a mouse asthma model
Int. Immunol., December 1, 2007; 19(12): 1371 - 1381.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Med.Home page
H. S. Bandukwala, B. S. Clay, J. Tong, P. D. Mody, J. L. Cannon, R. A. Shilling, J. S. Verbeek, J. V. Weinstock, J. Solway, and A. I. Sperling
Signaling through Fc{gamma}RIII is required for optimal T helper type (Th)2 responses and Th2-mediated airway inflammation
J. Exp. Med., August 6, 2007; 204(8): 1875 - 1889.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
P. M. O'Byrne
Cytokines or their antagonists for the treatment of asthma.
Chest, July 1, 2006; 130(1): 244 - 250.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
J. L. M. Vissers, B. C. A. M. van Esch, G. A. Hofman, and A. J. M. van Oosterhout
Macrophages induce an allergen-specific and long-term suppression in a mouse asthma model
Eur. Respir. J., December 1, 2005; 26(6): 1040 - 1046.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
K. Takeda, N. Miyahara, T. Kodama, C. Taube, A. Balhorn, A. Dakhama, K. Kitamura, A. Hirano, M. Tanimoto, and E. W. Gelfand
S-carboxymethylcysteine normalises airway responsiveness in sensitised and challenged mice
Eur. Respir. J., October 1, 2005; 26(4): 577 - 585.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
A. J. M. van Oosterhout and A. C. Motta
Th1/Th2 paradigm: not seeing the forest for the trees?
Eur. Respir. J., April 1, 2005; 25(4): 591 - 593.
[Full Text] [PDF]

Home page
 J. Exp. Med.Home page
L. S. van Rijt, S. Jung, A. KleinJan, N. Vos, M. Willart, C. Duez, H. C. Hoogsteden, and B. N. Lambrecht
In vivo depletion of lung CD11c+ dendritic cells during allergen challenge abrogates the characteristic features of asthma
J. Exp. Med., March 21, 2005; 201(6): 981 - 991.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
M. Peters-Golden
The Alveolar Macrophage: The Forgotten Cell in Asthma
Am. J. Respir. Cell Mol. Biol., July 1, 2004; 31(1): 3 - 7.
[Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
E. Careau and E. Y. Bissonnette
Adoptive Transfer of Alveolar Macrophages Abrogates Bronchial Hyperresponsiveness
Am. J. Respir. Cell Mol. Biol., July 1, 2004; 31(1): 22 - 27.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. D. Woolard, L. M. Hodge, H. P. Jones, T. R. Schoeb, and J. W. Simecka
The Upper and Lower Respiratory Tracts Differ in Their Requirement of IFN-{gamma} and IL-4 in Controlling Respiratory Mycoplasma Infection and Disease
J. Immunol., June 1, 2004; 172(11): 6875 - 6883.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. A. Aronica, S. McCarthy, S. Swaidani, D. Mitchell, M. Goral, J. R. Sheller, and M. Boothby
Recall Helper T Cell Response: T Helper 1 Cell-resistant Allergic Susceptibility without Biasing Uncommitted CD4 T Cells
Am. J. Respir. Crit. Care Med., March 1, 2004; 169(5): 587 - 595.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
S. C. Dorman, R. Sehmi, G. M. Gauvreau, R. M. Watson, R. Foley, G. L. Jones, J. A. Denburg, M. D. Inman, and P. M. O'Byrne
Kinetics of Bone Marrow Eosinophilopoiesis and Associated Cytokines after Allergen Inhalation
Am. J. Respir. Crit. Care Med., March 1, 2004; 169(5): 565 - 572.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
G. Pynaert, P. Rottiers, A. Haegeman, S. Sehra, T. Van Belle, J. Korf, and J. Grooten
Antigen Presentation by Local Macrophages Promotes Nonallergic Airway Responses in Sensitized Mice
Am. J. Respir. Cell Mol. Biol., November 1, 2003; 29(5): 634 - 641.
[Abstract] [Full Text]

Home page
 Am. J. Respir. Crit. Care Med.Home page
K. Takeda, N. Miyahara, Y.-H. Rha, C. Taube, E.-S. Yang, A. Joetham, T. Kodama, A. M. Balhorn, A. Dakhama, C. Duez, et al.
Surfactant Protein D Regulates Airway Function and Allergic Inflammation through Modulation of Macrophage Function
Am. J. Respir. Crit. Care Med., October 1, 2003; 168(7): 783 - 789.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. Sehra, G. Pynaert, K. Tournoy, A. Haegeman, P. Matthys, Y. Tagawa, R. Pauwels, and J. Grooten
Airway IgG Counteracts Specific and Bystander Allergen-Triggered Pulmonary Inflammation by a Mechanism Dependent on Fc{gamma}R and IFN-{gamma}
J. Immunol., August 15, 2003; 171(4): 2080 - 2089.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. S. Thomas, S. L. Kunkel, and N. W. Lukacs
Differential Role of IFN-{gamma}-Inducible Protein 10 kDa in a Cockroach Antigen-Induced Model of Allergic Airway Hyperreactivity: Systemic Versus Local Effects
J. Immunol., December 15, 2002; 169(12): 7045 - 7053.
[Abstract] [Full Text] [PDF]

Home page
 Hum Exp ToxicolHome page
R R Dietert, J-E Lee, and T L Bunn
Developmental immunotoxicology: emerging issues
Human and Experimental Toxicology, September 1, 2002; 21(9-10): 479 - 485.
[Abstract] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. Yoshida, R. Leigh, K. Matsumoto, J. Wattie, R. Ellis, P. M. O'Byrne, and M. D. Inman
Effect of Interferon-{gamma} on Allergic Airway Responses in Interferon-{gamma}-deficient Mice
Am. J. Respir. Crit. Care Med., August 15, 2002; 166(4): 451 - 456.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
E. M. Janssen, M. H. M. Wauben, F. P. Nijkamp, W. van Eden, and A. J. M. van Oosterhout
Immunomodulatory Effects of Antigen-Pulsed Macrophages in a Murine Model of Allergic Asthma
Am. J. Respir. Cell Mol. Biol., August 1, 2002; 27(2): 257 - 264.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
E. Kuroda, T. Kito, and U. Yamashita
Reduced Expression of STAT4 and IFN-{gamma} in Macrophages from BALB/c Mice
J. Immunol., June 1, 2002; 168(11): 5477 - 5482.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 2001 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 2001 by The American Association of Immunologists, Inc. All rights reserved.