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CUTTING EDGE |
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Department of Nephrology and Immunology, University of Aachen, Aachen, Germany;
Institute for Immunology, Ludwig-Maximilians-Universität München, München, Germany;
Max Planck Institute for Immunobiology, Freiburg, Germany; and
Medizinische Hochschule, Hannover, Germany
The mechanism of cross-presentation enables professional APCs to induce CD8 T cell-mediated immune responses against exogenous Ags. Through this mechanism, APCs can induce either immunity against infectious pathogens or tolerance against self-Ag residing in extralymphatic locations. An unanswered question in this field concerns the identity of the cross-presenting APC. All major classes of professional APCs, particularly dendritic cells, macrophages, and B cells, have previously been shown to be able to cross-present Ags in vitro. In the present study, we have created transgenic mice where MHC class I expression is driven selectively in dendritic cells and provide direct in vivo evidence that dendritic cells are sufficient to cross-present exogenous self-Ags and induce Ag-specific cell division of CD8-positive T cells.
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