| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
*
Centre National de la Recherche Scientifique, Unité Mixte de Recherche 8603, Université René Descartes, Paris V, Hôpital Necker, Paris, France;
Institut National de la Santé et de la Recherche Unité 25, Hôpital Necker, Paris, France;
Pharmaceutical Research Laboratory, Kirin Brewery Co., Ltd., Gunma, Japan;
Core Research for Evolutional Science and Technology and Department of Molecular Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan; and
¶ Howard Hughes Medical Institute, Vanderbilt University School of Medicine, Nashville, TN 37232
NKT cells are a remarkably versatile population whose functional
capacities are determined by cytokines present in their
microenvironment. In this study, we provide evidence for a new
immunoregulatory effect of the proinflammatory cytokine IL-18 on NKT
cells. We found that IL-18, mainly known for its involvement in NK cell
activation and in Th 1 immune responses, substantially enhanced IL-4
production as well as the percentage of IL-4+ cells among
NKT lymphocytes activated by their specific ligand
-galactosylceramide (-GalCer). The effect of IL-18 on IL-4
production by activated NKT cells took place both in vivo and in vitro
and was not affected by IL-12 which increased IFN-
secretion in the
same conditions. We show that NKT cells are the main targets for
IL-18-induced IL-4 production since it occurred neither in
NKT-deficient mice nor after stimulation of Th2 lymphocytes. Finally,
we provide evidence that the IL-4 promptly generated by NKT cells in
response to IL-18 plus -galactosylceramide in vivo can effectively
contribute to the adaptive Th2 immune response by up-regulating the
early activation marker CD69 on B cells. Our data support the notion
that, in contrast to the exclusive IFN- inducer IL-12, IL-18 acts in
a more subtle manner as a costimulatory factor in both pro-Th1 and
pro-Th2 responses depending on the nature of the stimulation and the
target cells.
This article has been cited by other articles:
|
|
 |
|
  L. T. Mars, A.-S. Gautron, J. Novak, L. Beaudoin, J. Diana, R. S. Liblau, and A. Lehuen Invariant NKT Cells Regulate Experimental Autoimmune Encephalomyelitis and Infiltrate the Central Nervous System in a CD1d-Independent Manner J. Immunol., August 15, 2008; 181(4): 2321 - 2329. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Bessoles, F. Fouret, S. Dudal, G. S. Besra, F. Sanchez, and V. Lafont IL-2 triggers specific signaling pathways in human NKT cells leading to the production of pro- and anti-inflammatory cytokines J. Leukoc. Biol., July 1, 2008; 84(1): 224 - 233. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M.-L. Michel, A. C. Keller, C. Paget, M. Fujio, F. Trottein, P. B. Savage, C.-H. Wong, E. Schneider, M. Dy, and M. C. Leite-de-Moraes Identification of an IL-17-producing NK1.1neg iNKT cell population involved in airway neutrophilia J. Exp. Med., May 14, 2007; 204(5): 995 - 1001. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Coquet, K. Kyparissoudis, D. G. Pellicci, G. Besra, S. P. Berzins, M. J. Smyth, and D. I. Godfrey IL-21 Is Produced by NKT Cells and Modulates NKT Cell Activation and Cytokine Production J. Immunol., March 1, 2007; 178(5): 2827 - 2834. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. H. Meyer, S. Goya, O. Akbari, G. J. Berry, P. B. Savage, M. Kronenberg, T. Nakayama, R. H. DeKruyff, and D. T. Umetsu Glycolipid activation of invariant T cell receptor+ NK T cells is sufficient to induce airway hyperreactivity independent of conventional CD4+ T cells PNAS, February 21, 2006; 103(8): 2782 - 2787. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Bilenki, S. Wang, J. Yang, Y. Fan, A. G. Joyee, and X. Yang NK T Cell Activation Promotes Chlamydia trachomatis Infection In Vivo J. Immunol., September 1, 2005; 175(5): 3197 - 3206. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Minami, Y. Yanagawa, K. Iwabuchi, N. Shinohara, T. Harabayashi, K. Nonomura, and K. Onoe Negative feedback regulation of T helper type 1 (Th1)/Th2 cytokine balance via dendritic cell and natural killer T cell interactions Blood, September 1, 2005; 106(5): 1685 - 1693. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Ranson, S. Bregenholt, A. Lehuen, O. Gaillot, M. C. Leite-de-Moraes, A. Herbelin, P. Berche, and J. P. Di Santo Invariant V{alpha}14+ NKT Cells Participate in the Early Response to Enteric Listeria monocytogenes Infection J. Immunol., July 15, 2005; 175(2): 1137 - 1144. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. de Lalla, G. Galli, L. Aldrighetti, R. Romeo, M. Mariani, A. Monno, S. Nuti, M. Colombo, F. Callea, S. A. Porcelli, et al. Production of Profibrotic Cytokines by Invariant NKT Cells Characterizes Cirrhosis Progression in Chronic Viral Hepatitis J. Immunol., July 15, 2004; 173(2): 1417 - 1425. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. Xu, E. Goleva, L.-S. Ou, L.-B. Li, and D. Y. M. Leung CD56+ Cells Induce Steroid Resistance in B Cells Exposed to IL-15 J. Immunol., June 1, 2004; 172(11): 7110 - 7115. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Matsuda, L. Gapin, J. L. Baron, S. Sidobre, D. B. Stetson, M. Mohrs, R. M. Locksley, and M. Kronenberg Mouse V{alpha}14i natural killer T cells are resistant to cytokine polarization in vivo PNAS, July 8, 2003; 100(14): 8395 - 8400. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Yoshimoto, B. Min, T. Sugimoto, N. Hayashi, Y. Ishikawa, Y. Sasaki, H. Hata, K. Takeda, K. Okumura, L. Van Kaer, et al. Nonredundant Roles for CD1d-restricted Natural Killer T Cells and Conventional CD4+ T Cells in the Induction of Immunoglobulin E Antibodies in Response to Interleukin 18 Treatment of Mice J. Exp. Med., April 21, 2003; 197(8): 997 - 1005. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Reddy, T. Teshima, G. Hildebrandt, D. L. Williams, C. Liu, K. R. Cooke, and J. L.M. Ferrara Pretreatment of donors with interleukin-18 attenuates acute graft-versus-host disease via STAT6 and preserves graft-versus-leukemia effects Blood, April 1, 2003; 101(7): 2877 - 2885. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Metwali, A. Blum, D. E. Elliott, and J. V. Weinstock Interleukin-4 Receptor {alpha} Chain and STAT6 Signaling Inhibit Gamma Interferon but Not Th2 Cytokine Expression within Schistosome Granulomas Infect. Immun., October 1, 2002; 70(10): 5651 - 5658. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Smyth, N. Y. Crowe, D. G. Pellicci, K. Kyparissoudis, J. M. Kelly, K. Takeda, H. Yagita, and D. I. Godfrey Sequential production of interferon-gamma by NK1.1+ T cells and natural killer cells is essential for the antimetastatic effect of alpha -galactosylceramide Blood, February 15, 2002; 99(4): 1259 - 1266. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Okamoto, S. Kato, K. Oizumi, M. Kinoshita, Y. Inoue, K. Hoshino, S. Akira, A. N. J. Mckenzie, H. A. Young, and T. Hoshino Interleukin 18 (IL-18) in synergy with IL-2 induces lethal lung injury in mice: a potential role for cytokines, chemokines, and natural killer cells in the pathogenesis of interstitial pneumonia Blood, February 15, 2002; 99(4): 1289 - 1298. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. K. Singh, M. T. Wilson, S. Hong, D. Olivares-Villagomez, C. Du, A. K. Stanic, S. Joyce, S. Sriram, Y. Koezuka, and L. Van Kaer Natural Killer T Cell Activation Protects Mice Against Experimental Autoimmune Encephalomyelitis J. Exp. Med., December 17, 2001; 194(12): 1801 - 1811. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Kawakami, Y. Kinjo, S. Yara, K. Uezu, Y. Koguchi, M. Tohyama, M. Azuma, K. Takeda, S. Akira, and A. Saito Enhanced Gamma Interferon Production through Activation of Valpha 14+ Natural Killer T Cells by alpha -Galactosylceramide in Interleukin-18-Deficient Mice with Systemic Cryptococcosis Infect. Immun., November 1, 2001; 69(11): 6643 - 6650. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Maeda, S. Lohwasser, T. Yamamura, and F. Takei Regulation of NKT Cells by Ly49: Analysis of Primary NKT Cells and Generation of NKT Cell Line J. Immunol., October 15, 2001; 167(8): 4180 - 4186. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Hoshino, Y. Kawase, M. Okamoto, K. Yokota, K. Yoshino, K.-i. Yamamura, J.-i. Miyazaki, H. A. Young, and K. Oizumi Cutting Edge: IL-18-Transgenic Mice: In Vivo Evidence of a Broad Role for IL-18 in Modulating Immune Function J. Immunol., June 15, 2001; 166(12): 7014 - 7018. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Nishikomori, S. Gurunathan, K. Nishikomori, and W. Strober BALB/c Mice Bearing a Transgenic IL-12 Receptor {{beta}}2 Gene Exhibit a Nonhealing Phenotype to Leishmania major Infection Despite Intact IL-12 Signaling J. Immunol., June 1, 2001; 166(11): 6776 - 6783. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. M. Walter, C. P. Wong, R. H. DeKruyff, G. J. Berry, S. Levy, and D. T. Umetsu IL-18 Gene Transfer by Adenovirus Prevents the Development of and Reverses Established Allergen-Induced Airway Hyperreactivity J. Immunol., May 15, 2001; 166(10): 6392 - 6398. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
