| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742
Defining the cellular composition of the memory T cell pool has been complicated by an inability to distinguish effector and memory T cells. We present here an activation profile assay, using anti-CD3 and antigenic stimuli, that clearly distinguishes effector and memory CD4 T cells and defines subsets of long-lived memory CD4 T cells based on CD62 ligand (CD62L) expression. The CD62Llow memory subset functionally resembles effector cells, exhibiting hyper-responsiveness to antigenic and anti-CD3 mediated stimuli, high proliferative capacity, and rapid activation kinetics. The CD62Lhigh memory subset functionally resembles resting memory cells, exhibiting hyporesponsiveness to anti-CD3 stimuli, lower proliferative capacity, and slower activation kinetics. Our results indicate that the memory CD4 T cell pool is heterogeneous, consisting of persisting effectors and resting memory T cells.
This article has been cited by other articles:
|
|
 |
|
  E. Adeeku, P. Gudapati, Y. Mendez-Fernandez, L. Van Kaer, and M. Boothby Flexibility accompanies commitment of memory CD4 lymphocytes derived from IL-4 locus-activated precursors PNAS, July 8, 2008; 105(27): 9307 - 9312. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Soroosh, S. Ine, K. Sugamura, and N. Ishii Differential Requirements for OX40 Signals on Generation of Effector and Central Memory CD4+ T Cells J. Immunol., October 15, 2007; 179(8): 5014 - 5023. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. R. Chandok, F. I. Okoye, M. P. Ndejembi, and D. L. Farber A Biochemical Signature for Rapid Recall of Memory CD4 T Cells J. Immunol., September 15, 2007; 179(6): 3689 - 3698. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Barbey, E. Pradervand, N. Barbier, and F. Spertini Ex Vivo Monitoring of Antigen-Specific CD4+ T Cells after Recall Immunization with Tetanus Toxoid Clin. Vaccine Immunol., September 1, 2007; 14(9): 1108 - 1116. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. M. Jelley-Gibbs, J. P. Dibble, D. M. Brown, T. M. Strutt, K. K. McKinstry, and S. L. Swain Persistent Depots of Influenza Antigen Fail To Induce a Cytotoxic CD8 T Cell Response J. Immunol., June 15, 2007; 178(12): 7563 - 7570. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Y. Kimura, C. Iwamura, A. Suzuki, T. Miki, A. Hasegawa, K. Sugaya, M. Yamashita, S. Ishii, and T. Nakayama Schnurri-2 Controls Memory Th1 and Th2 Cell Numbers In Vivo J. Immunol., April 15, 2007; 178(8): 4926 - 4936. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. J. Blossom, J. C. Doss, and K. M. Gilbert Chronic Exposure to a Trichloroethylene Metabolite in Autoimmune-Prone MRL+/+ Mice Promotes Immune Modulation and Alopecia Toxicol. Sci., February 1, 2007; 95(2): 401 - 411. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. P. Ndejembi, J. R. Teijaro, D. S. Patke, A. W. Bingaman, M. R. Chandok, A. Azimzadeh, S. G. Nadler, and D. L. Farber Control of Memory CD4 T Cell Recall by the CD28/B7 Costimulatory Pathway J. Immunol., December 1, 2006; 177(11): 7698 - 7706. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. R. Moulton, N. D. Bushar, D. B. Leeser, D. S. Patke, and D. L. Farber Divergent Generation of Heterogeneous Memory CD4 T Cells J. Immunol., July 15, 2006; 177(2): 869 - 876. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. MacLeod, M. J. Kwakkenbos, A. Crawford, S. Brown, B. Stockinger, K. Schepers, T. Schumacher, and D. Gray CD4 memory T cells survive and proliferate but fail to differentiate in the absence of CD40 J. Exp. Med., April 17, 2006; 203(4): 897 - 906. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. S. Obhrai, M. H. Oberbarnscheidt, T. W. Hand, L. Diggs, G. Chalasani, and F. G. Lakkis Effector T Cell Differentiation and Memory T Cell Maintenance Outside Secondary Lymphoid Organs J. Immunol., April 1, 2006; 176(7): 4051 - 4058. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. R. O. Salvalaggio, G. Camirand, C. E. Ariyan, S. Deng, L. Rogozinski, G. P. Basadonna, and D. M. Rothstein Antigen Exposure during Enhanced CTLA-4 Expression Promotes Allograft Tolerance In Vivo J. Immunol., February 15, 2006; 176(4): 2292 - 2298. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Wuthrich, T. Warner, and B. S. Klein IL-12 Is Required for Induction but Not Maintenance of Protective, Memory Responses to Blastomyces dermatitidis: Implications for Vaccine Development in Immune-Deficient Hosts J. Immunol., October 15, 2005; 175(8): 5288 - 5297. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. M. Jelley-Gibbs, D. M. Brown, J. P. Dibble, L. Haynes, S. M. Eaton, and S. L. Swain Unexpected prolonged presentation of influenza antigens promotes CD4 T cell memory generation J. Exp. Med., September 6, 2005; 202(5): 697 - 706. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Parameswaran, R. Suresh, V. Bal, S. Rath, and A. George Lack of ICAM-1 on APCs during T Cell Priming Leads to Poor Generation of Central Memory Cells J. Immunol., August 15, 2005; 175(4): 2201 - 2211. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Kawakami, F. Odoardi, T. Ziemssen, M. Bradl, T. Ritter, O. Neuhaus, H. Lassmann, H. Wekerle, and A. Flugel Autoimmune CD4+ T Cell Memory: Lifelong Persistence of Encephalitogenic T Cell Clones in Healthy Immune Repertoires J. Immunol., July 1, 2005; 175(1): 69 - 81. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. S. Patke and D. L. Farber Modulation of Memory CD4 T Cell Function and Survival Potential by Altering the Strength of the Recall Stimulus J. Immunol., May 1, 2005; 174(9): 5433 - 5443. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Harari, F. Vallelian, P. R. Meylan, and G. Pantaleo Functional Heterogeneity of Memory CD4 T Cell Responses in Different Conditions of Antigen Exposure and Persistence J. Immunol., January 15, 2005; 174(2): 1037 - 1045. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Yamashita, R. Shinnakasu, Y. Nigo, M. Kimura, A. Hasegawa, M. Taniguchi, and T. Nakayama Interleukin (IL)-4-independent Maintenance of Histone Modification of the IL-4 Gene Loci in Memory Th2 Cells J. Biol. Chem., September 17, 2004; 279(38): 39454 - 39464. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. S. Zand, B. J. Briggs, A. Bose, and T. Vo Discrete Event Modeling of CD4+ Memory T Cell Generation J. Immunol., September 15, 2004; 173(6): 3763 - 3772. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Andris, S. Denanglaire, F. de Mattia, J. Urbain, and O. Leo Naive T Cells Are Resistant to Anergy Induction by Anti-CD3 Antibodies J. Immunol., September 1, 2004; 173(5): 3201 - 3208. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Ichii, A. Sakamoto, Y. Kuroda, and T. Tokuhisa Bcl6 Acts as an Amplifier for the Generation and Proliferative Capacity of Central Memory CD8+ T Cells J. Immunol., July 15, 2004; 173(2): 883 - 891. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. J. Chen, X. Cui, G. D. Sempowski, C. Liu, and N. J. Chao Transfer of allogeneic CD62L- memory T cells without graft-versus-host disease Blood, February 15, 2004; 103(4): 1534 - 1541. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Bellier, V. Thomas-Vaslin, M.-F. Saron, and D. Klatzmann Turning immunological memory into amnesia by depletion of dividing T cells PNAS, December 9, 2003; 100(25): 15017 - 15022. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Haynes, S. M. Eaton, E. M. Burns, T. D. Randall, and S. L. Swain CD4 T cell memory derived from young naive cells functions well into old age, but memory generated from aged naive cells functions poorly PNAS, December 9, 2003; 100(25): 15053 - 15058. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Kruse, K. Varming, and O.B. Christiansen Prospective, serial investigations of in-vitro lymphocyte cytokine production, CD62L expression and proliferative response to microbial antigens in women with recurrent miscarriage Hum. Reprod., November 1, 2003; 18(11): 2465 - 2472. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Krishnan, D. L. Farber, and G. C. Tsokos T Cell Rewiring in Differentiation and Disease J. Immunol., October 1, 2003; 171(7): 3325 - 3331. [Full Text] [PDF]
|
|
|
|
|
|
L. Lefrancois, A. Marzo, and K. Williams Sustained Response Initiation Is Required for T Cell Clonal Expansion But Not for Effector or Memory Development In Vivo J. Immunol., September 15, 2003; 171(6): 2832 - 2839. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. L. Hengel, V. Thaker, M. V. Pavlick, J. A. Metcalf, G. Dennis Jr., J. Yang, R. A. Lempicki, I. Sereti, and H. C. Lane Cutting Edge: L-Selectin (CD62L) Expression Distinguishes Small Resting Memory CD4+ T Cells That Preferentially Respond to Recall Antigen J. Immunol., January 1, 2003; 170(1): 28 - 32. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Mojtabavi, G. Dekan, G. Stingl, and M. M. Epstein Long-Lived Th2 Memory in Experimental Allergic Asthma J. Immunol., November 1, 2002; 169(9): 4788 - 4796. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Suresh, M. Vig, S. Bhatia, E. P. B. Goodspeed, B. John, U. Kandpal, S. Srivastava, A. George, R. Sen, V. Bal, et al. Pentoxifylline Functions As an Adjuvant In Vivo to Enhance T Cell Immune Responses by Inhibiting Activation-Induced Death J. Immunol., October 15, 2002; 169(8): 4262 - 4272. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Ahmadzadeh and D. L. Farber Functional plasticity of an antigen-specific memory CD4 T cell population PNAS, September 3, 2002; 99(18): 11802 - 11807. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Y. Park, B. Hondowicz, M. Kopf, and P. Scott The Role of IL-12 in Maintaining Resistance to Leishmania major J. Immunol., June 1, 2002; 168(11): 5771 - 5777. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. F. Hussain, C. F. Anderson, and D. L. Farber Differential SLP-76 Expression and TCR-Mediated Signaling in Effector and Memory CD4 T Cells J. Immunol., February 15, 2002; 168(4): 1557 - 1565. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Sakatsume, Y. Xie, M. Ueno, H. Obayashi, S. Goto, I. Narita, N. Homma, K. Tasaki, Y. Suzuki, and F. Gejyo Human Glomerulonephritis Accompanied by Active Cellular Infiltrates Shows Effector T Cells in Urine J. Am. Soc. Nephrol., December 1, 2001; 12(12): 2636 - 2644. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
