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Uterine Macrophages Express the gp49B Inhibitory Receptor in Midgestation¹

Yukie Matsumoto^2,*, Lawrence L. Wang, Wayne M. Yokoyama and Takeshi Aso^*

^* Department of Obstetrics and Gynecology, Faculty of Medicine, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, Japan; and Department of Medicine, Rheumatology Division, Howard Hughes Medical Institute, Washington University School of Medicine, St. Louis, MO 63110

Mouse gp49B is an immunoreceptor tyrosine-based inhibitory motif-bearing receptor identified on mast cells and NK cells. In this report, however, we show that this receptor is expressed on macrophages accumulating in the uterine metrial gland in midgestation, along with gp49A that has a very homologous extracellular domain with gp49B but has a short cytoplasmic domain without ITIM. Culture of bone marrow cells in the conditioned medium of the metrial gland resulted in the selective proliferation of macrophages expressing both Fc-activating receptors and gp49B inhibitory receptor. Stimulation of macrophages with immobilized IgG, but not with anti-FcRII/III, induced a considerable amount of TNF- and IL-10 production, suggesting that the high-affinity receptor for IgG (FcRI) can transmit activating signals in cytokine production of macrophages. Furthermore, coligation of gp49B with FcRI resulted in the inhibition of TNF- production. Thus, our data provide evidence that gp49B is an endogenous negative regulator of macrophage activation and may regulate the function of macrophages during pregnancy.

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