| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Department of Molecular and Cellular Engineering, Institute for Human Gene Therapy, University of Pennsylvania School of Medicine, Philadelphia, PA 19104
TRAIL, the TNF-related apoptosis-inducing ligand, induces apoptosis of tumor cells, but not normal cells; the roles of TRAIL in nontransformed tissues are unknown. Using a soluble TRAIL receptor, we examined the consequences of TRAIL blockade in an animal model of multiple sclerosis. We found that chronic TRAIL blockade in mice exacerbated experimental autoimmune encephalomyelitis induced by myelin oligodendrocyte glycoprotein. The exacerbation was evidenced primarily by increases in disease score and degree of inflammation in the CNS. Interestingly, the degree of apoptosis of inflammatory cells in the CNS was not affected by TRAIL blockade, suggesting that TRAIL may not regulate apoptosis of inflammatory cells in experimental autoimmune encephalomyelitis. By contrast, myelin oligodendrocyte glycoprotein-specific Th1 and Th2 cell responses were significantly enhanced in animals treated with the soluble TRAIL receptor. Based on these observations, we conclude that unlike TNF, which promotes autoimmune inflammation, TRAIL inhibits autoimmune encephalomyelitis and prevents activation of autoreactive T cells.
This article has been cited by other articles:
|
|
 |
|
  M. Razmara, B. Hilliard, A. K. Ziarani, R. Murali, S. Yellayi, M. Ghazanfar, Y. H. Chen, and M. L. Tykocinski Fn14-TRAIL, a Chimeric Intercellular Signal Exchanger, Attenuates Experimental Autoimmune Encephalomyelitis Am. J. Pathol., February 1, 2009; 174(2): 460 - 474. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Cao, P. Du, S.-H. Jiang, G.-H. Jin, Q.-L. Huang, and Z.-C. Hua Enhancement of antitumor properties of TRAIL by targeted delivery to the tumor neovasculature Mol. Cancer Ther., April 1, 2008; 7(4): 851 - 861. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Cretney, A. P. Uldrich, F. W. McNab, D. I. Godfrey, and M. J. Smyth No requirement for TRAIL in intrathymic negative selection Int. Immunol., February 1, 2008; 20(2): 267 - 276. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Rus, V. Nguyen, R. Puliaev, I. Puliaeva, V. Zernetkina, I. Luzina, J. C. Papadimitriou, and C. S. Via T Cell TRAIL Promotes Murine Lupus by Sustaining Effector CD4 Th Cell Numbers and by Inhibiting CD8 CTL Activity J. Immunol., March 15, 2007; 178(6): 3962 - 3972. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. S. Griffith, H. Kazama, R. L. VanOosten, J. K. Earle Jr., J. M. Herndon, D. R. Green, and T. A. Ferguson Apoptotic Cells Induce Tolerance by Generating Helpless CD8+ T Cells That Produce TRAIL J. Immunol., March 1, 2007; 178(5): 2679 - 2687. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Hirata, H. Matsuyoshi, D. Fukuma, A. Kurisaki, Y. Uemura, Y. Nishimura, and S. Senju Involvement of Regulatory T Cells in the Experimental Autoimmune Encephalomyelitis-Preventive Effect of Dendritic Cells Expressing Myelin Oligodendrocyte Glycoprotein plus TRAIL J. Immunol., January 15, 2007; 178(2): 918 - 925. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Murata, M. Tsuboi, K. Hikita, and N. Kaneda Protective Effects of Neurotrophic Factors on Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL)-mediated Apoptosis of Murine Adrenal Chromaffin Cell Line tsAM5D J. Biol. Chem., August 11, 2006; 281(32): 22503 - 22516. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Aktas, T. Prozorovski, and F. Zipp Death Ligands and Autoimmune Demyelination Neuroscientist, August 1, 2006; 12(4): 305 - 316. [Abstract] [PDF]
|
|
|
|
 |
|
 M. A. Cassatella On the production of TNF-related apoptosis-inducing ligand (TRAIL/Apo-2L) by human neutrophils J. Leukoc. Biol., June 1, 2006; 79(6): 1140 - 1149. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N Arbour, E Rastikerdar, E McCrea, Y Lapierre, J Dorr, A Bar-Or, and J P Antel Upregulation of TRAIL expression on human T lymphocytes by interferon b and glatiramer acetate Multiple Sclerosis, December 1, 2005; 11(6): 652 - 657. [Abstract] [PDF]
|
|
|
|
 |
|
 S. H. Wang, Z. Cao, J. M. Wolf, M. Van Antwerp, and J. R. Baker Jr. Death Ligand Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Inhibits Experimental Autoimmune Thyroiditis Endocrinology, November 1, 2005; 146(11): 4721 - 4726. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Sun, B. Hilliard, L. Xu, and Y. H. Chen Essential Roles of the Fas-Associated Death Domain in Autoimmune Encephalomyelitis J. Immunol., October 1, 2005; 175(7): 4783 - 4788. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Yang, J. Wang, C. Liu, W. E. Grizzle, S. Yu, S. Zhang, S. Barnes, W. J. Koopman, J. D. Mountz, R. P. Kimberly, et al. Cleavage of p53-Vimentin Complex Enhances Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand-Mediated Apoptosis of Rheumatoid Arthritis Synovial Fibroblasts Am. J. Pathol., September 1, 2005; 167(3): 705 - 719. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. J. Lum, G. Bren, R. McClure, and A. D. Badley Elimination of Senescent Neutrophils by TNF-Related Apotosis-Inducing Ligand J. Immunol., July 15, 2005; 175(2): 1232 - 1238. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M N Lub-de Hooge, E G E de Vries, S de Jong, and M Bijl Soluble TRAIL concentrations are raised in patients with systemic lupus erythematosus Ann Rheum Dis, June 1, 2005; 64(6): 854 - 858. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Michowitz, E. Goldstein, A. Roth, A. Afek, A. Abashidze, Y. Ben Gal, G. Keren, and J. George The involvement of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in atherosclerosis J. Am. Coll. Cardiol., April 5, 2005; 45(7): 1018 - 1024. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Bosque, J. Pardo, M{a} J. Martinez-Lorenzo, M. Iturralde, I. Marzo, A. Pineiro, M{a} A. Alava, J. Naval, and A. Anel Down-regulation of normal human T cell blast activation: roles of APO2L/TRAIL, FasL, and c- FLIP, Bim, or Bcl-x isoform expression J. Leukoc. Biol., April 1, 2005; 77(4): 568 - 578. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Sato, T. Nakaoka, N. Yamashita, H. Yagita, H. Kawasaki, C. Morimoto, M. Baba, and T. Matsuyama TRAIL-Transduced Dendritic Cells Protect Mice from Acute Graft-versus-Host Disease and Leukemia Relapse J. Immunol., April 1, 2005; 174(7): 4025 - 4033. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Liu, T. Miwa, B. Hilliard, Y. Chen, J. D. Lambris, A. D. Wells, and W.-C. Song The complement inhibitory protein DAF (CD55) suppresses T cell immunity in vivo J. Exp. Med., February 22, 2005; 201(4): 567 - 577. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Hirata, S. Senju, H. Matsuyoshi, D. Fukuma, Y. Uemura, and Y. Nishimura Prevention of Experimental Autoimmune Encephalomyelitis by Transfer of Embryonic Stem Cell-Derived Dendritic Cells Expressing Myelin Oligodendrocyte Glycoprotein Peptide along with TRAIL or Programmed Death-1 Ligand J. Immunol., February 15, 2005; 174(4): 1888 - 1897. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Harada, Y. Osuga, T. Hirata, Y. Hirota, K. Koga, O. Yoshino, C. Morimoto, T. Fujiwara, M. Momoeda, T. Yano, et al. Concentration of osteoprotegerin (OPG) in peritoneal fluid is increased in women with endometriosis Hum. Reprod., October 1, 2004; 19(10): 2188 - 2191. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Matsuyama, M. Yamamoto, I. Higashimoto, K.-i. Oonakahara, M. Watanabe, K. Machida, T. Yoshimura, N. Eiraku, M. Kawabata, M. Osame, et al. TNF-related apoptosis-inducing ligand is involved in neutropenia of systemic lupus erythematosus Blood, July 1, 2004; 104(1): 184 - 191. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. C. Spierings, E. G. de Vries, E. Vellenga, F. A. van den Heuvel, J. J. Koornstra, J. Wesseling, H. Hollema, and S. de Jong Tissue Distribution of the Death Ligand TRAIL and Its Receptors J. Histochem. Cytochem., June 1, 2004; 52(6): 821 - 831. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S.-E. Lamhamedi-Cherradi, S. Zheng, R. M. Tisch, and Y. H. Chen Critical Roles of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand in Type 1 Diabetes Diabetes, September 1, 2003; 52(9): 2274 - 2278. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Cretney, A. P. Uldrich, S. P. Berzins, A. Strasser, D. I. Godfrey, and M. J. Smyth Normal Thymocyte Negative Selection in TRAIL-deficient Mice J. Exp. Med., August 4, 2003; 198(3): 491 - 496. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q.-S. Mi, D. Ly, S.-E. Lamhamedi-Cherradi, K. V. Salojin, L. Zhou, M. Grattan, C. Meagher, P. Zucker, Y. H. Chen, J. Nagle, et al. Blockade of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Exacerbates Type 1 Diabetes in NOD Mice Diabetes, August 1, 2003; 52(8): 1967 - 1975. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Matysiak, A. Jurewicz, D. Jaskolski, and K. Selmaj TRAIL induces death of human oligodendrocytes isolated from adult brain Brain, November 1, 2002; 125(11): 2469 - 2480. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-o. Lee, J. M. Herndon, R. Barreiro, T. S. Griffith, and T. A. Ferguson TRAIL: A Mechanism of Tumor Surveillance in an Immune Privileged Site J. Immunol., November 1, 2002; 169(9): 4739 - 4744. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Lunemann, S. Waiczies, S. Ehrlich, U. Wendling, B. Seeger, T. Kamradt, and F. Zipp Death Ligand TRAIL Induces No Apoptosis but Inhibits Activation of Human (Auto)antigen-Specific T Cells J. Immunol., May 15, 2002; 168(10): 4881 - 4888. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Cretney, K. Takeda, H. Yagita, M. Glaccum, J. J. Peschon, and M. J. Smyth Increased Susceptibility to Tumor Initiation and Metastasis in TNF-Related Apoptosis-Inducing Ligand-Deficient Mice J. Immunol., February 1, 2002; 168(3): 1356 - 1361. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Takeda, M. J. Smyth, E. Cretney, Y. Hayakawa, N. Kayagaki, H. Yagita, and K. Okumura Critical Role for Tumor Necrosis Factor-related Apoptosis-inducing Ligand in Immune Surveillance Against Tumor Development J. Exp. Med., January 14, 2002; 195(2): 161 - 169. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P.-O. Vidalain, O. Azocar, H. Yagita, C. Rabourdin-Combe, and C. Servet-Delprat Cytotoxic Activity of Human Dendritic Cells Is Differentially Regulated by Double-Stranded RNA and CD40 Ligand J. Immunol., October 1, 2001; 167(7): 3765 - 3772. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A.-H. Chou, H.-F. Tsai, L.-L. Lin, S.-L. Hsieh, P.-I Hsu, and P.-N. Hsu Enhanced Proliferation and Increased IFN-{gamma} Production in T Cells by Signal Transduced Through TNF-Related Apoptosis-Inducing Ligand J. Immunol., August 1, 2001; 167(3): 1347 - 1352. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
