| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
in Response to Bacterial Pathogens1
*
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom;
Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen, Thailand; and
School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104
The bacterium Burkholderia pseudomallei causes a
life-threatening disease called melioidosis. In vivo experiments in
mice have identified that a rapid IFN-
response is essential for
host survival. To identify the cellular sources of IFN-, spleen
cells from uninfected mice were stimulated with B.
pseudomallei in vitro and assayed by ELISA and flow cytometry.
Costaining for intracellular IFN- vs cell surface markers
demonstrated that NK cells and, more surprisingly, CD8+ T
cells were the dominant sources of IFN-. IFN-+ NK
cells were detectable after 5 h and IFN-+
CD8+ T cells within 15 h after addition of bacteria.
IFN- production by both cell populations was inhibited by
coincubation with neutralizing mAb to IL-12 or IL-18, while a mAb to
TNF had much less effect. Three-color flow cytometry showed that
IFN--producing CD8+ T cells were of the
CD44high phenotype. The preferential activation of NK cells
and CD8+ T cells, rather than CD4+ T cells, was
also observed in response to Listeria monocytogenes or a
combination of IL-12 and IL-18 both in vitro and in vivo. This
rapid mechanism of CD8+ T cell activation may be an
important component of innate immunity to intracellular
pathogens.
This article has been cited by other articles:
|
|
 |
|
  J. M. Warawa, D. Long, R. Rosenke, D. Gardner, and F. C. Gherardini Role for the Burkholderia pseudomallei Capsular Polysaccharide Encoded by the wcb Operon in Acute Disseminated Melioidosis Infect. Immun., December 1, 2009; 77(12): 5252 - 5261. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Maroof, L. Beattie, A. Kirby, M. Coles, and P. M. Kaye Dendritic Cells Matured by Inflammation Induce CD86-Dependent Priming of Naive CD8+ T Cells in the Absence of Their Cognate Peptide Antigen J. Immunol., December 1, 2009; 183(11): 7095 - 7103. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Vesosky, E. K. Rottinghaus, C. Davis, and J. Turner CD8 T Cells in Old Mice Contribute to the Innate Immune Response to Mycobacterium tuberculosis via Interleukin-12p70-Dependent and Antigen-Independent Production of Gamma Interferon Infect. Immun., August 1, 2009; 77(8): 3355 - 3363. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Okoye, H. Park, M. Rohankhedkar, L. Coyne-Johnson, R. Lum, J. M. Walker, S. L. Planer, A. W. Legasse, A. W. Sylwester, M. Piatak Jr., et al. Profound CD4+/CCR5+ T cell expansion is induced by CD8+ lymphocyte depletion but does not account for accelerated SIV pathogenesis J. Exp. Med., July 6, 2009; 206(7): 1575 - 1588. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. S. Haring and J. T. Harty Interleukin-18-Related Genes Are Induced during the Contraction Phase but Do Not Play Major Roles in Regulating the Dynamics or Function of the T-Cell Response to Listeria monocytogenes Infection Infect. Immun., May 1, 2009; 77(5): 1894 - 1903. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Goodyear, L. Kellihan, H. Bielefeldt-Ohmann, R. Troyer, K. Propst, and S. Dow Protection from Pneumonic Infection with Burkholderia Species by Inhalational Immunotherapy Infect. Immun., April 1, 2009; 77(4): 1579 - 1588. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. N. Bou Ghanem, D. S. McElroy, and S. E. F. D'Orazio Multiple Mechanisms Contribute to the Robust Rapid Gamma Interferon Response by CD8+ T Cells during Listeria monocytogenes Infection Infect. Immun., April 1, 2009; 77(4): 1492 - 1501. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Sattler, U. Wagner, M. Rossol, J. Sieper, P. Wu, A. Krause, W. A. Schmidt, S. Radmer, S. Kohler, C. Romagnani, et al. Cytokine-induced human IFN-{gamma}-secreting effector-memory Th cells in chronic autoimmune inflammation Blood, February 26, 2009; 113(9): 1948 - 1956. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. C. Bangs, D. Baban, H. J. Cattan, C. K.-F. Li, A. J. McMichael, and X.-N. Xu Human CD4+ Memory T Cells Are Preferential Targets for Bystander Activation and Apoptosis J. Immunol., February 15, 2009; 182(4): 1962 - 1971. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. De Pascalis, B. C. Taylor, and K. L. Elkins Diverse Myeloid and Lymphoid Cell Subpopulations Produce Gamma Interferon during Early Innate Immune Responses to Francisella tularensis Live Vaccine Strain Infect. Immun., September 1, 2008; 76(9): 4311 - 4321. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Ye, C. M. L. Lee, G. W. Sun, and Y.-H. Gan Burkholderia pseudomallei Infection of T Cells Leads to T-Cell Costimulation Partially Provided by Flagellin Infect. Immun., June 1, 2008; 76(6): 2541 - 2550. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G.-Y. G. Tan, Y. Liu, S. P. Sivalingam, S.-H. Sim, D. Wang, J.-C. Paucod, Y. Gauthier, and E.-E. Ooi Burkholderia pseudomallei aerosol infection results in differential inflammatory responses in BALB/c and C57Bl/6 mice J. Med. Microbiol., April 1, 2008; 57(4): 508 - 515. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H.-W. Mittrucker, U. Steinhoff, A. Kohler, M. Krause, D. Lazar, P. Mex, D. Miekley, and S. H. E. Kaufmann Poor correlation between BCG vaccination-induced T cell responses and protection against tuberculosis PNAS, July 24, 2007; 104(30): 12434 - 12439. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. S. Wagner, G. C. Riise, T. Bergstrom, K. Karre, E. Carbone, and L. Berg Increased Expression of Leukocyte Ig-Like Receptor-1 and Activating Role of UL18 in the Response to Cytomegalovirus Infection J. Immunol., March 15, 2007; 178(6): 3536 - 3543. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Kosaka, D. Wakita, N. Matsubara, Y. Togashi, S.-I. Nishimura, H. Kitamura, and T. Nishimura AsialoGM1+CD8+ central memory-type T cells in unimmunized mice as novel immunomodulator of IFN-{gamma}-dependent type 1 immunity Int. Immunol., March 1, 2007; 19(3): 249 - 256. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Masopust, K. Murali-Krishna, and R. Ahmed Quantitating the Magnitude of the Lymphocytic Choriomeningitis Virus-Specific CD8 T-Cell Response: It Is Even Bigger than We Thought J. Virol., February 15, 2007; 81(4): 2002 - 2011. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. E. F. D'Orazio, M. J. Troese, and M. N. Starnbach Cytosolic Localization of Listeria monocytogenes Triggers an Early IFN-{gamma} Response by CD8+ T Cells That Correlates with Innate Resistance to Infection J. Immunol., November 15, 2006; 177(10): 7146 - 7154. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Breitbach, S. Klocke, T. Tschernig, N. van Rooijen, U. Baumann, and I. Steinmetz Role of Inducible Nitric Oxide Synthase and NADPH Oxidase in Early Control of Burkholderia pseudomallei Infection in Mice Infect. Immun., November 1, 2006; 74(11): 6300 - 6309. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. A. Rowland, G. Lertmemongkolchai, A. Bancroft, A. Haque, M. S. Lever, K. F. Griffin, M. C. Jackson, M. Nelson, A. O'Garra, R. Grencis, et al. Critical Role of Type 1 Cytokines in Controlling Initial Infection with Burkholderia mallei Infect. Immun., September 1, 2006; 74(9): 5333 - 5340. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. L. Reinhardt, S. Hong, S.-J. Kang, Z.-e. Wang, and R. M. Locksley Visualization of IL-12/23p40 In Vivo Reveals Immunostimulatory Dendritic Cell Migrants that Promote Th1 Differentiation J. Immunol., August 1, 2006; 177(3): 1618 - 1627. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Dhanji, M. T. Chow, and H.-S. Teh Self-Antigen Maintains the Innate Antibacterial Function of Self-Specific CD8 T Cells In Vivo J. Immunol., July 1, 2006; 177(1): 138 - 146. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Kubota A novel functional T cell hybridoma recognizes macrophage cell death induced by bacteria: a possible role for innate lymphocytes in bacterial infection. J. Immunol., June 15, 2006; 176(12): 7576 - 7588. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Vesosky, D. K. Flaherty, and J. Turner Th1 Cytokines Facilitate CD8-T-Cell-Mediated Early Resistance to Infection with Mycobacterium tuberculosis in Old Mice. Infect. Immun., June 1, 2006; 74(6): 3314 - 3324. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. T. Borchers, N. L. Harris, S. C. Wesselkamper, S. Zhang, Y. Chen, L. Young, and G. W. Lau The NKG2D-Activating Receptor Mediates Pulmonary Clearance of Pseudomonas aeruginosa. Infect. Immun., May 1, 2006; 74(5): 2578 - 2586. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Polley, S. Stager, S. Prickett, A. Maroof, S. Zubairi, D. F. Smith, and P. M. Kaye Adoptive Immunotherapy against Experimental Visceral Leishmaniasis with CD8+ T Cells Requires the Presence of Cognate Antigen Infect. Immun., January 1, 2006; 74(1): 773 - 776. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Polley, S. L. Sanos, S. Prickett, A. Haque, and P. M. Kaye Chronic Leishmania donovani Infection Promotes Bystander CD8+-T-Cell Expansion and Heterologous Immunity Infect. Immun., December 1, 2005; 73(12): 7996 - 8001. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. A. Leav, M. Yoshida, K. Rogers, S. Cohen, N. Godiwala, R. S. Blumberg, and H. Ward An Early Intestinal Mucosal Source of Gamma Interferon Is Associated with Resistance to and Control of Cryptosporidium parvum Infection in Mice Infect. Immun., December 1, 2005; 73(12): 8425 - 8428. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Su, R. E. Berg, S. Murray, and J. Forman Thymus-Dependent Memory Phenotype CD8 T Cells in Naive B6.H-2Kb-/-Db-/- Animals Mediate an Antigen-Specific Response against Listeria monocytogenes J. Immunol., November 15, 2005; 175(10): 6450 - 6457. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Mitchell, A. M. Hansen, L. Hee, H. J. Ball, S. M. Potter, J. C. Walker, and N. H. Hunt Early Cytokine Production Is Associated with Protection from Murine Cerebral Malaria Infect. Immun., September 1, 2005; 73(9): 5645 - 5653. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. E. Berg, E. Crossley, S. Murray, and J. Forman Relative Contributions of NK and CD8 T Cells to IFN-{gamma} Mediated Innate Immune Protection against Listeria monocytogenes J. Immunol., August 1, 2005; 175(3): 1751 - 1757. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Arce, H. F. Nawar, M. W. Russell, and T. D. Connell Differential Binding of Escherichia coli Enterotoxins LT-IIa and LT-IIb and of Cholera Toxin Elicits Differences in Apoptosis, Proliferation, and Activation of Lymphoid Cells Infect. Immun., May 1, 2005; 73(5): 2718 - 2727. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. C. Cheng and B. J. Currie Melioidosis: Epidemiology, Pathophysiology, and Management Clin. Microbiol. Rev., April 1, 2005; 18(2): 383 - 416. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Beadling and M. K. Slifka Differential regulation of virus-specific T-cell effector functions following activation by peptide or innate cytokines Blood, February 1, 2005; 105(3): 1179 - 1186. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Mavropoulos, G. Sully, A. P. Cope, and A. R. Clark Stabilization of IFN-{gamma} mRNA by MAPK p38 in IL-12- and IL-18-stimulated human NK cells Blood, January 1, 2005; 105(1): 282 - 288. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Gilbertson, S. Germano, P. Steele, S. Turner, B. F. de St. Groth, and C. Cheers Bystander Activation of CD8+ T Lymphocytes during Experimental Mycobacterial Infection Infect. Immun., December 1, 2004; 72(12): 6884 - 6891. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-P. Raue, J. D. Brien, E. Hammarlund, and M. K. Slifka Activation of Virus-Specific CD8+ T Cells by Lipopolysaccharide-Induced IL-12 and IL-18 J. Immunol., December 1, 2004; 173(11): 6873 - 6881. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. C. Kirby, M. Sundquist, and M. J. Wick In Vivo Compartmentalization of Functionally Distinct, Rapidly Responsive Antigen-Specific T-Cell Populations in DNA-Immunized or Salmonella enterica Serovar Typhimurium-Infected Mice Infect. Immun., November 1, 2004; 72(11): 6390 - 6400. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Dhanji, S.-J. Teh, D. Oble, J. J. Priatel, and H.-S. Teh Self-reactive memory-phenotype CD8 T cells exhibit both MHC-restricted and non-MHC-restricted cytotoxicity: a role for the T-cell receptor and natural killer cell receptors Blood, October 1, 2004; 104(7): 2116 - 2123. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Granucci, I. Zanoni, N. Pavelka, S. L.H. van Dommelen, C. E. Andoniou, F. Belardelli, M. A. Degli Esposti, and P. Ricciardi-Castagnoli A Contribution of Mouse Dendritic Cell-Derived IL-2 for NK Cell Activation J. Exp. Med., August 2, 2004; 200(3): 287 - 295. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Wongratanacheewin, W. Kespichayawattana, P. Intachote, S. Pichyangkul, R. W. Sermswan, A. M. Krieg, and S. Sirisinha Immunostimulatory CpG Oligodeoxynucleotide Confers Protection in a Murine Model of Infection with Burkholderia pseudomallei Infect. Immun., August 1, 2004; 72(8): 4494 - 4502. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Tao and E. R. Sherwood {beta}2-Microglobulin knockout mice treated with anti-asialoGM1 exhibit improved hemodynamics and cardiac contractile function during acute intra-abdominal sepsis Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2004; 286(3): R569 - R575. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Dakic, Q.-x. Shao, A. D'Amico, M. O'Keeffe, W.-f. Chen, K. Shortman, and L. Wu Development of the Dendritic Cell System during Mouse Ontogeny J. Immunol., January 15, 2004; 172(2): 1018 - 1027. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. E. Berg, E. Crossley, S. Murray, and J. Forman Memory CD8+ T Cells Provide Innate Immune Protection against Listeria monocytogenes in the Absence of Cognate Antigen J. Exp. Med., November 17, 2003; 198(10): 1583 - 1593. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Kambayashi, E. Assarsson, A. E. Lukacher, H.-G. Ljunggren, and P. E. Jensen Memory CD8+ T Cells Provide an Early Source of IFN-{gamma} J. Immunol., March 1, 2003; 170(5): 2399 - 2408. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.M. JONES, J.F. ELLIS, P. RUSSELL, K.F. GRIFFIN, and P.C. F. OYSTON Passive protection against Burkholderia pseudomallei infection in mice by monoclonal antibodies against capsular polysaccharide, lipopolysaccharide or proteins J. Med. Microbiol., December 1, 2002; 51(12): 1055 - 1062. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. S. Lundin, C. Johansson, and A.-M. Svennerholm Oral Immunization with a Salmonella enterica Serovar Typhi Vaccine Induces Specific Circulating Mucosa-Homing CD4+ and CD8+ T Cells in Humans Infect. Immun., October 1, 2002; 70(10): 5622 - 5627. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Artavanis-Tsakonas and E. M. Riley Innate Immune Response to Malaria: Rapid Induction of IFN-{gamma} from Human NK Cells by Live Plasmodium falciparum-Infected Erythrocytes J. Immunol., September 15, 2002; 169(6): 2956 - 2963. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Muller-Suur, K. Larsson, and J. Grunewald Organic dust-induced interleukin-12 production activates T- and natural killer cells Eur. Respir. J., September 1, 2002; 20(3): 686 - 690. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Haller, P. Serrant, D. Granato, E. J. Schiffrin, and S. Blum Activation of Human NK Cells by Staphylococci and Lactobacilli Requires Cell Contact-Dependent Costimulation by Autologous Monocytes Clin. Vaccine Immunol., May 1, 2002; 9(3): 649 - 657. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Zerrahn, U. E. Schaible, V. Brinkmann, U. Guhlich, and S. H. E. Kaufmann The IFN-Inducible Golgi- and Endoplasmic Reticulum- Associated 47-kDa GTPase IIGP Is Transiently Expressed During Listeriosis J. Immunol., April 1, 2002; 168(7): 3428 - 3436. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Robinson, K. R. Neal, C. Howard, J. Stockton, K. Atkinson, E. Scarth, J. Moran, A. Robins, I. Todd, E. Kaczmarski, et al. Characterization of Humoral and Cellular Immune Responses Elicited by Meningococcal Carriage Infect. Immun., March 1, 2002; 70(3): 1301 - 1309. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. C. Hope, P. Sopp, and C. J. Howard NK-like CD8+ cells in immunologically naive neonatal calves that respond to dendritic cells infected with Mycobacterium bovis BCG J. Leukoc. Biol., February 1, 2002; 71(2): 184 - 194. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Lassmann, C. Kincaid, V. C. Asensio, and I. L. Campbell Induction of Type 1 Immune Pathology in the Brain Following Immunization Without Central Nervous System Autoantigen in Transgenic Mice With Astrocyte-Targeted Expression of IL-12 J. Immunol., November 1, 2001; 167(9): 5485 - 5493. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 U. Seydel, O. Scheel, M. Muller, K. Brandenburg, and R. Blunck A K+ channel is involved in LPS signaling Innate Immunity, June 1, 2001; 7(3): 243 - 247. [Abstract] [PDF]
|
|
|
|
|
|
V. Tieng, C. Le Bouguenec, L. du Merle, P. Bertheau, P. Desreumaux, A. Janin, D. Charron, and A. Toubert From the Cover: Binding of Escherichia coli adhesin AfaE to CD55 triggers cell-surface expression of the MHC class I-related molecule MICA PNAS, March 5, 2002; 99(5): 2977 - 2982. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
