The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Haziot, A.
Right arrow Articles by Goyert, S. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Haziot, A.
Right arrow Articles by Goyert, S. M.
The Journal of Immunology, 2001, 166: 1075-1078.
Copyright © 2001 by The American Association of Immunologists

Induction of a Novel Mechanism of Accelerated Bacterial Clearance by Lipopolysaccharide in CD14-Deficient and Toll-Like Receptor 4-Deficient Mice1

Alain Haziot, Naoki Hijiya, Sophie C. Gangloff, Jack Silver and Sanna M. Goyert2

Division of Molecular Medicine, North Shore University Hospital/New York University School of Medicine, Manhasset, NY 11030

Despite the lack of a proinflammatory response to LPS, CD14-deficient mice clear Gram-negative bacteria (Escherichia coli 0111) at least 10 times more efficiently than normal mice. In this study, we show that this is due to an early and intense recruitment of neutrophils following the injection of Gram-negative bacteria or LPS in CD14-deficient mice; in contrast, neutrophil infiltration is delayed by 24 h in normal mice. Similar results of early LPS-induced PMN infiltration and enhanced clearance of E. coli were seen in Toll-like receptor (TLR) 4-deficient mice. Furthermore, the lipid A moiety of LPS induced early neutrophil infiltration not only in CD14-deficient and TLR-4-deficient mice, but also in normal mice. In conclusion, the lipid A component of LPS stimulates a unique and critical pathway of innate immune responses that is independent of CD14 and TLR4 and results in early neutrophil infiltration and enhanced bacterial clearance.




This article has been cited by other articles:


Home page
 Cardiovasc ResHome page
J. M. Gitlin and C. D. Loftin
Cyclooxygenase-2 inhibition increases lipopolysaccharide-induced atherosclerosis in mice
Cardiovasc Res, February 1, 2009; 81(2): 400 - 407.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
H. Komura, M. Miksa, R. Wu, S. M. Goyert, and P. Wang
Milk Fat Globule Epidermal Growth Factor-Factor VIII Is Down-Regulated in Sepsis via the Lipopolysaccharide-CD14 Pathway
J. Immunol., January 1, 2009; 182(1): 581 - 587.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
R. Ramphal, V. Balloy, J. Jyot, A. Verma, M. Si-Tahar, and M. Chignard
Control of Pseudomonas aeruginosa in the Lung Requires the Recognition of Either Lipopolysaccharide or Flagellin
J. Immunol., July 1, 2008; 181(1): 586 - 592.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
T. G. Loof, O. Goldmann, and E. Medina
Immune Recognition of Streptococcus pyogenes by Dendritic Cells
Infect. Immun., June 1, 2008; 76(6): 2785 - 2792.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
N. Kesteman, G. Vansanten, B. Pajak, S. M. Goyert, and M. Moser
Injection of lipopolysaccharide induces the migration of splenic neutrophils to the T cell area of the white pulp: role of CD14 and CXC chemokines
J. Leukoc. Biol., March 1, 2008; 83(3): 640 - 647.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
G. F. Weber, S. Schlautkotter, S. Kaiser-Moore, F. Altmayr, B. Holzmann, and H. Weighardt
Inhibition of Interleukin-22 Attenuates Bacterial Load and Organ Failure during Acute Polymicrobial Sepsis
Infect. Immun., April 1, 2007; 75(4): 1690 - 1697.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
T. Furuta, T. Kikuchi, S. Akira, N. Watanabe, and Y. Yoshikawa
Roles of the small intestine for induction of toll-like receptor 4-mediated innate resistance in naturally acquired murine toxoplasmosis
Int. Immunol., December 1, 2006; 18(12): 1655 - 1662.
[Abstract] [Full Text] [PDF]

Home page
 Innate ImmunityHome page
J. H. Fritz and S. E. Girardin
How Toll-like receptors and Nod-like receptors contribute to innate immunity in mammals
Innate Immunity, December 1, 2005; 11(6): 390 - 394.
[Abstract] [PDF]

Home page
 Arch Otolaryngol Head Neck SurgHome page
T. Luxameechanporn, V. Kirtsreesakul, J. Klemens, P. Khoury, K. Thompson, and R. M. Naclerio
Evaluation of Importance of Toll-like Receptor 4 in Acute Streptococcus pneumoniae Sinusitis in Mice
Arch Otolaryngol Head Neck Surg, November 1, 2005; 131(11): 1001 - 1006.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
J. S. Lee, C. W. Frevert, G. Matute-Bello, M. M. Wurfel, V. A. Wong, S.-M. Lin, J. Ruzinski, S. Mongovin, R. B. Goodman, and T. R. Martin
TLR-4 pathway mediates the inflammatory response but not bacterial elimination in E. coli pneumonia
Am J Physiol Lung Cell Mol Physiol, November 1, 2005; 289(5): L731 - L738.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
H. Echchannaoui, K. Frei, M. Letiembre, R. M. Strieter, Y. Adachi, and R. Landmann
CD14 deficiency leads to increased MIP-2 production, CXCR2 expression, neutrophil transmigration, and early death in pneumococcal infection
J. Leukoc. Biol., September 1, 2005; 78(3): 705 - 715.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
C. Feterowski, A. Novotny, S. Kaiser-Moore, P. F. Muhlradt, T. Rossmann-Bloeck, M. Rump, B. Holzmann, and H. Weighardt
Attenuated pathogenesis of polymicrobial peritonitis in mice after TLR2 agonist pre-treatment involves ST2 up-regulation
Int. Immunol., August 1, 2005; 17(8): 1035 - 1046.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
E. Lorenz, D. C. Chemotti, A. L. Jiang, and L. D. McDougal
Differential Involvement of Toll-Like Receptors 2 and 4 in the Host Response to Acute Respiratory Infections with Wild-Type and Mutant Haemophilus influenzae Strains
Infect. Immun., April 1, 2005; 73(4): 2075 - 2082.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
R. Jimenez, E. Belcher, S. Sriskandan, R. Lucas, S. McMaster, I. Vojnovic, T. D. Warner, and J. A. Mitchell
Role of Toll-like receptors 2 and 4 in the induction of cyclooxygenase-2 in vascular smooth muscle
PNAS, March 22, 2005; 102(12): 4637 - 4642.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
R. P. Darveau, T.-T. T. Pham, K. Lemley, R. A. Reife, B. W. Bainbridge, S. R. Coats, W. N. Howald, S. S. Way, and A. M. Hajjar
Porphyromonas gingivalis Lipopolysaccharide Contains Multiple Lipid A Species That Functionally Interact with Both Toll-Like Receptors 2 and 4
Infect. Immun., September 1, 2004; 72(9): 5041 - 5051.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. J. Skerrett, H. D. Liggitt, A. M. Hajjar, and C. B. Wilson
Cutting Edge: Myeloid Differentiation Factor 88 Is Essential for Pulmonary Host Defense against Pseudomonas aeruginosa but Not Staphylococcus aureus
J. Immunol., March 15, 2004; 172(6): 3377 - 3381.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
P. N. Cunningham, Y. Wang, R. Guo, G. He, and R. J. Quigg
Role of Toll-Like Receptor 4 in Endotoxin-Induced Acute Renal Failure
J. Immunol., February 15, 2004; 172(4): 2629 - 2635.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
J. Branger, S. Knapp, S. Weijer, J. C. Leemans, J. M. Pater, P. Speelman, S. Florquin, and T. van der Poll
Role of Toll-Like Receptor 4 in Gram-Positive and Gram-Negative Pneumonia in Mice
Infect. Immun., February 1, 2004; 72(2): 788 - 794.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
I. Glezer, H. Zekki, C. Scavone, and S. Rivest
Modulation of the Innate Immune Response by NMDA Receptors Has Neuropathological Consequences
J. Neurosci., December 3, 2003; 23(35): 11094 - 11103.
[Abstract] [Full Text] [PDF]

Home page
 Innate ImmunityHome page
T. Axtelle and J. Pribble
An overview of clinical studies in healthy subjects and patients with severe sepsis with IC14, a CD14-specific chimeric monoclonal antibody
Innate Immunity, December 1, 2003; 9(6): 385 - 389.
[Abstract] [PDF]

Home page
 Infect. Immun.Home page
S. Knapp, A. F. de Vos, S. Florquin, D. T. Golenbock, and T. van der Poll
Lipopolysaccharide Binding Protein Is an Essential Component of the Innate Immune Response to Escherichia coli Peritonitis in Mice
Infect. Immun., December 1, 2003; 71(12): 6747 - 6753.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Microbiol. Rev.Home page
E. S. Van Amersfoort, T. J. C. Van Berkel, and J. Kuiper
Receptors, Mediators, and Mechanisms Involved in Bacterial Sepsis and Septic Shock
Clin. Microbiol. Rev., July 1, 2003; 16(3): 379 - 414.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
J.-W. Lee, M. J. Paape, T. H. Elsasser, and X. Zhao
Recombinant Soluble CD14 Reduces Severity of Intramammary Infection by Escherichia coli
Infect. Immun., July 1, 2003; 71(7): 4034 - 4039.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
T. Pedron, R. Girard, and R. Chaby
TLR4-dependent Lipopolysaccharide-induced Shedding of Tumor Necrosis Factor Receptors in Mouse Bone Marrow Granulocytes
J. Biol. Chem., May 30, 2003; 278(23): 20555 - 20564.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
M. P. Radsak, N. Hilf, H. Singh-Jasuja, S. Braedel, P. Brossart, H.-G. Rammensee, and H. Schild
The heat shock protein Gp96 binds to human neutrophils and monocytes and stimulates effector functions
Blood, April 1, 2003; 101(7): 2810 - 2815.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
A. Ayala, C.-S. Chung, J. L. Lomas, G. Y. Song, L. A. Doughty, S. H. Gregory, W. G. Cioffi, B. W. LeBlanc, J. Reichner, H. H. Simms, et al.
Shock-Induced Neutrophil Mediated Priming for Acute Lung Injury in Mice: Divergent Effects of TLR-4 and TLR-4/FasL Deficiency
Am. J. Pathol., December 1, 2002; 161(6): 2283 - 2294.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
K. K. Yang, B. G. Dorner, U. Merkel, B. Ryffel, C. Schutt, D. Golenbock, M. W. Freeman, and R. S. Jack
Neutrophil Influx in Response to a Peritoneal Infection with Salmonella Is Delayed in Lipopolysaccharide-Binding Protein or CD14-Deficient Mice
J. Immunol., October 15, 2002; 169(8): 4475 - 4480.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
B. Abel, N. Thieblemont, V. J. F. Quesniaux, N. Brown, J. Mpagi, K. Miyake, F. Bihl, and B. Ryffel
Toll-Like Receptor 4 Expression Is Required to Control Chronic Mycobacterium tuberculosis Infection in Mice
J. Immunol., September 15, 2002; 169(6): 3155 - 3162.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
T. M. Doherty, A. W. Olsen, L. van Pinxteren, and P. Andersen
Oral Vaccination with Subunit Vaccines Protects Animals against Aerosol Infection with Mycobacterium tuberculosis
Infect. Immun., June 1, 2002; 70(6): 3111 - 3121.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
D. A. Schwartz
The Genetics of Innate Immunity
Chest, March 1, 2002; 121(2007): 62S - 68S.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
J. Zweigner, H.-J. Gramm, O. C. Singer, K. Wegscheider, and R. R. Schumann
High concentrations of lipopolysaccharide-binding protein in serum of patients with severe sepsis or septic shock inhibit the lipopolysaccharide response in human monocytes
Blood, December 15, 2001; 98(13): 3800 - 3808.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. R. Bleharski, K. R. Niazi, P. A. Sieling, G. Cheng, and R. L. Modlin
Signaling Lymphocytic Activation Molecule Is Expressed on CD40 Ligand-Activated Dendritic Cells and Directly Augments Production of Inflammatory Cytokines
J. Immunol., September 15, 2001; 167(6): 3174 - 3181.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 2001 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 2001 by The American Association of Immunologists, Inc. All rights reserved.