The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 QUICK SEARCH:   [advanced]


     
 


This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Abe, R.
Right arrow Articles by Metz, C. N.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Abe, R.
Right arrow Articles by Metz, C. N.
Right arrowPubmed/NCBI databases
*Substance via MeSH
The Journal of Immunology, 2001, 166: 7556-7562.
Copyright © 2001 by The American Association of Immunologists

Peripheral Blood Fibrocytes: Differentiation Pathway and Migration to Wound Sites1

Riichiro Abe*, Seamas C. Donnelly*, Tina Peng*, Richard Bucala{dagger} and Christine N. Metz2,*

Laboratory of * Vascular Biology and {dagger} Medical Biochemistry, The Picower Institute for Medical Research, Manhasset, NY 11030

Fibrocytes are a distinct population of blood-borne cells that display a unique cell surface phenotype (collagen I+/CD11b+/CD13+/CD34+/CD45RO+/MHC class II+/CD86+) and exhibit potent immunostimulatory activities. Circulating fibrocytes rapidly enter sites of tissue injury, suggesting an important role for these cells in wound repair. However, the regulatory processes that govern the differentiation of blood-borne fibrocytes and the mechanisms that underlie the migration of these cells to wound sites are currently not known. We report herein that ex vivo cultured fibrocytes can differentiate from a CD14+-enriched mononuclear cell population and that this process requires contact with T cells. Furthermore, we demonstrate that TGF-{beta}1 (1–10 ng/ml), an important fibrogenic and growth-regulating cytokine involved in wound healing, increases the differentiation and functional activity of cultured fibrocytes. Because fibrocytes home to sites of tissue injury, we examined the role of chemokine/chemokine receptor interactions in fibrocyte trafficking. We show that secondary lymphoid chemokine, a ligand of the CCR7 chemokine receptor, acts as a potent stimulus for fibrocyte chemotaxis in vitro and for the homing of injected fibrocytes to sites of cutaneous tissue injury in vivo. Finally, we demonstrate that differentiated, cultured fibrocytes express {alpha} smooth muscle actin and contract collagen gels in vitro, two characteristic features of wound-healing myofibroblasts. These data provide important insight into the control of fibrocyte differentiation and trafficking during tissue repair and significantly expand their potential role during wound healing.




This article has been cited by other articles:


Home page
Am. J. Pathol.Home page
W. D. Hardie, S. W. Glasser, and J. S. Hagood
Emerging Concepts in the Pathogenesis of Lung Fibrosis
Am. J. Pathol., July 1, 2009; 175(1): 3 - 16.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
N. Nasreen, K. A. Mohammed, K. K. Mubarak, M. A. Baz, O. A. Akindipe, S. Fernandez-Bussy, and V. B. Antony
Pleural mesothelial cell transformation into myofibroblasts and haptotactic migration in response to TGF-{beta}1 in vitro
Am J Physiol Lung Cell Mol Physiol, July 1, 2009; 297(1): L115 - L124.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Respir. Crit. Care Med.Home page
A. Moeller, S. E. Gilpin, K. Ask, G. Cox, D. Cook, J. Gauldie, P. J. Margetts, L. Farkas, J. Dobranowski, C. Boylan, et al.
Circulating Fibrocytes Are an Indicator of Poor Prognosis in Idiopathic Pulmonary Fibrosis
Am. J. Respir. Crit. Care Med., April 1, 2009; 179(7): 588 - 594.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Pathol.Home page
W. Wang, H. Pan, K. Murray, B. S. Jefferson, and Y. Li
Matrix Metalloproteinase-1 Promotes Muscle Cell Migration and Differentiation
Am. J. Pathol., February 1, 2009; 174(2): 541 - 549.
[Abstract] [Full Text] [PDF]


Home page
ERRHome page
R. C. Chambers
Abnormal wound healing responses in pulmonary fibrosis: focus on coagulation signalling
Eur. Respir. Rev., December 1, 2008; 17(109): 130 - 137.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
S. M. Majka, M. Skokan, L. Wheeler, J. Harral, S. Gladson, E. Burnham, J. E. Loyd, K. R. Stenmark, M. Varella-Garcia, and J. West
Evidence for cell fusion is absent in vascular lesions associated with pulmonary arterial hypertension
Am J Physiol Lung Cell Mol Physiol, December 1, 2008; 295(6): L1028 - L1039.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Pathol.Home page
S.-L. Lin, T. Kisseleva, D. A. Brenner, and J. S. Duffield
Pericytes and Perivascular Fibroblasts Are the Primary Source of Collagen-Producing Cells in Obstructive Fibrosis of the Kidney
Am. J. Pathol., December 1, 2008; 173(6): 1617 - 1627.
[Abstract] [Full Text] [PDF]


Home page
Infect. Immun.Home page
I. Stamm, M. Mohr, P. S. Bridger, E. Schropfer, M. Konig, W. C. Stoffregen, E. A. Dean-Nystrom, G. Baljer, and C. Menge
Epithelial and Mesenchymal Cells in the Bovine Colonic Mucosa Differ in Their Responsiveness to Escherichia coli Shiga Toxin 1
Infect. Immun., November 1, 2008; 76(11): 5381 - 5391.
[Abstract] [Full Text] [PDF]


Home page
J. Immunol.Home page
Y. Wu, Y.-Y. Li, K. Matsushima, T. Baba, and N. Mukaida
CCL3-CCR5 Axis Regulates Intratumoral Accumulation of Leukocytes and Fibroblasts and Promotes Angiogenesis in Murine Lung Metastasis Process
J. Immunol., November 1, 2008; 181(9): 6384 - 6393.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Respir. Crit. Care Med.Home page
C.-H. Wang, C.-D. Huang, H.-C. Lin, K.-Y. Lee, S.-M. Lin, C.-Y. Liu, K.-H. Huang, Y.-S. Ko, K. F. Chung, and H.-P. Kuo
Increased Circulating Fibrocytes in Asthma with Chronic Airflow Obstruction
Am. J. Respir. Crit. Care Med., September 15, 2008; 178(6): 583 - 591.
[Abstract] [Full Text] [PDF]


Home page
Proc Am Thorac SocHome page
M. R. Loebinger, E. K. Sage, and S. M. Janes
Mesenchymal Stem Cells as Vectors for Lung Disease
Proceedings of the ATS, August 15, 2008; 5(6): 711 - 716.
[Abstract] [Full Text] [PDF]


Home page
Proc. Natl. Acad. Sci. USAHome page
S. B. Haudek, J. Trial, Y. Xia, D. Gupta, D. Pilling, and M. L. Entman
Fc receptor engagement mediates differentiation of cardiac fibroblast precursor cells
PNAS, July 22, 2008; 105(29): 10179 - 10184.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Pathol.Home page
H. W. van Deventer, Q. P. Wu, D. T. Bergstralh, B. K. Davis, B. P. O'Connor, J. P.-Y. Ting, and J. S. Serody
C-C Chemokine Receptor 5 on Pulmonary Fibrocytes Facilitates Migration and Promotes Metastasis via Matrix Metalloproteinase 9
Am. J. Pathol., July 1, 2008; 173(1): 253 - 264.
[Abstract] [Full Text] [PDF]


Home page
J. Leukoc. Biol.Home page
D. D. Shao, R. Suresh, V. Vakil, R. H. Gomer, and D. Pilling
Pivotal Advance: Th-1 cytokines inhibit, and Th-2 cytokines promote fibrocyte differentiation
J. Leukoc. Biol., June 1, 2008; 83(6): 1323 - 1333.
[Abstract] [Full Text] [PDF]


Home page
Br. J. Ophthalmol.Home page
A M A. El-Asrar, S Struyf, J Van Damme, and K Geboes
Circulating fibrocytes contribute to the myofibroblast population in proliferative vitreoretinopathy epiretinal membranes
Br. J. Ophthalmol., May 1, 2008; 92(5): 699 - 704.
[Abstract] [Full Text] [PDF]


Home page
Proc Am Thorac SocHome page
S. H. Phan
Biology of Fibroblasts and Myofibroblasts
Proceedings of the ATS, April 15, 2008; 5(3): 334 - 337.
[Abstract] [Full Text] [PDF]


Home page
Ther Adv Respir DisHome page
P. Rogliani, M. Mura, M. Assunta Porretta, and C. Saltini
Review: New perspectives in the treatment of idiopathic pulmonary fibrosis
Therapeutic Advances in Respiratory Disease, April 1, 2008; 2(2): 75 - 93.
[Abstract] [PDF]


Home page
J. Immunol.Home page
T. Kielian, M. Md. Syed, S. Liu, N. K. Phulwani, N. Phillips, G. Wagoner, P. D. Drew, and N. Esen
The Synthetic Peroxisome Proliferator-Activated Receptor-{gamma} Agonist Ciglitazone Attenuates Neuroinflammation and Accelerates Encapsulation in Bacterial Brain Abscesses
J. Immunol., April 1, 2008; 180(7): 5004 - 5016.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Respir. Crit. Care Med.Home page
T. R. McMillan, B. B. Moore, J. B. Weinberg, K. M. Vannella, W. B. Fields, P. J. Christensen, L. F. van Dyk, and G. B. Toews
Exacerbation of Established Pulmonary Fibrosis in a Murine Model by Gammaherpesvirus
Am. J. Respir. Crit. Care Med., April 1, 2008; 177(7): 771 - 780.
[Abstract] [Full Text] [PDF]


Home page
Proc Am Thorac SocHome page
S. R. Singh and I. P. Hall
Airway Myofibroblasts and Their Relationship with Airway Myocytes and Fibroblasts
Proceedings of the ATS, January 1, 2008; 5(1): 127 - 132.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Respir. Crit. Care Med.Home page
A. Serrano-Mollar, M. Nacher, G. Gay-Jordi, D. Closa, A. Xaubet, and O. Bulbena
Intratracheal Transplantation of Alveolar Type II Cells Reverses Bleomycin-induced Lung Fibrosis
Am. J. Respir. Crit. Care Med., December 15, 2007; 176(12): 1261 - 1268.
[Abstract] [Full Text] [PDF]


Home page
J. Leukoc. Biol.Home page
J. Wang, H. Jiao, T. L. Stewart, M. V. H. Lyons, H. A. Shankowsky, P. G. Scott, and E. E. Tredget
Accelerated wound healing in leukocyte-specific, protein 1-deficient mouse is associated with increased infiltration of leukocytes and fibrocytes
J. Leukoc. Biol., December 1, 2007; 82(6): 1554 - 1563.
[Abstract] [Full Text] [PDF]


Home page
J. Immunol.Home page
K. M. Vannella, T. R. McMillan, R. P. Charbeneau, C. A. Wilke, P. E. Thomas, G. B. Toews, M. Peters-Golden, and B. B. Moore
Cysteinyl Leukotrienes Are Autocrine and Paracrine Regulators of Fibrocyte Function
J. Immunol., December 1, 2007; 179(11): 7883 - 7890.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Pathol.Home page
A. Medina, R. T. Kilani, N. Carr, E. Brown, and A. Ghahary
Transdifferentiation of Peripheral Blood Mononuclear Cells into Epithelial-Like Cells
Am. J. Pathol., October 1, 2007; 171(4): 1140 - 1152.
[Abstract] [Full Text] [PDF]


Home page
J. Immunol.Home page
D. Pilling, D. Roife, M. Wang, S. D. Ronkainen, J. R. Crawford, E. L. Travis, and R. H. Gomer
Reduction of Bleomycin-Induced Pulmonary Fibrosis by Serum Amyloid P
J. Immunol., September 15, 2007; 179(6): 4035 - 4044.
[Abstract] [Full Text] [PDF]


Home page
J. Leukoc. Biol.Home page
B. N. Gomperts and R. M. Strieter
Fibrocytes in lung disease
J. Leukoc. Biol., September 1, 2007; 82(3): 449 - 456.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
K. M. Hong, J. A. Belperio, M. P. Keane, M. D. Burdick, and R. M. Strieter
Differentiation of Human Circulating Fibrocytes as Mediated by Transforming Growth Factor-beta and Peroxisome Proliferator-activated Receptor {gamma}
J. Biol. Chem., August 3, 2007; 282(31): 22910 - 22920.
[Abstract] [Full Text] [PDF]


Home page
J R Soc InterfaceHome page
A. D Metcalfe and M. W.J Ferguson
Tissue engineering of replacement skin: the crossroads of biomaterials, wound healing, embryonic development, stem cells and regeneration
J R Soc Interface, June 22, 2007; 4(14): 413 - 437.
[Abstract] [Full Text] [PDF]


Home page
Eur Respir JHome page
E. M. Pierce, K. Carpenter, C. Jakubzick, S. L. Kunkel, H. Evanoff, K. R. Flaherty, F. J. Martinez, G. B. Toews, and C. M. Hogaboam
Idiopathic pulmonary fibrosis fibroblasts migrate and proliferate to CC chemokine ligand 21
Eur. Respir. J., June 1, 2007; 29(6): 1082 - 1093.
[Abstract] [Full Text] [PDF]


Home page
Stem CellsHome page
G. Ishii, T.-K. Ito, K. Aoyagi, H. Fujimoto, H. Chiba, T. Hasebe, S. Fujii, K. Nagai, H. Sasaki, and A. Ochiai
Presence of Human Circulating Progenitor Cells for Cancer Stromal Fibroblasts in the Blood of Lung Cancer Patients
Stem Cells, June 1, 2007; 25(6): 1469 - 1477.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Pathol.Home page
B. Hinz, S. H. Phan, V. J. Thannickal, A. Galli, M.-L. Bochaton-Piallat, and G. Gabbiani
The Myofibroblast: One Function, Multiple Origins
Am. J. Pathol., June 1, 2007; 170(6): 1807 - 1816.
[Abstract] [Full Text] [PDF]


Home page
Mol Hum ReprodHome page
E. Malmstrom, M. Sennstrom, A. Holmberg, H. Frielingsdorf, E. Eklund, L. Malmstrom, E. Tufvesson, M. F. Gomez, G. Westergren-Thorsson, G. Ekman-Ordeberg, et al.
The importance of fibroblasts in remodelling of the human uterine cervix during pregnancy and parturition
Mol. Hum. Reprod., May 1, 2007; 13(5): 333 - 341.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Pathol.Home page
E. M. Pierce, K. Carpenter, C. Jakubzick, S. L. Kunkel, K. R. Flaherty, F. J. Martinez, and C. M. Hogaboam
Therapeutic Targeting of CC Ligand 21 or CC Chemokine Receptor 7 Abrogates Pulmonary Fibrosis Induced by the Adoptive Transfer of Human Pulmonary Fibroblasts to Immunodeficient Mice
Am. J. Pathol., April 1, 2007; 170(4): 1152 - 1164.
[Abstract] [Full Text] [PDF]


Home page
Eur Respir JHome page
A. Scheja, K. Larsen, L. Todorova, E. Tufvesson, M. Wildt, A. Akesson, L. Hansson, S. Ellis, and G. Westergren Thorsson
BALF-derived fibroblasts differ from biopsy-derived fibroblasts in systemic sclerosis
Eur. Respir. J., March 1, 2007; 29(3): 446 - 452.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Pathol.Home page
Y. Ishida, A. Kimura, T. Kondo, T. Hayashi, M. Ueno, N. Takakura, K. Matsushima, and N. Mukaida
Essential Roles of the CC Chemokine Ligand 3-CC Chemokine Receptor 5 Axis in Bleomycin-Induced Pulmonary Fibrosis through Regulation of Macrophage and Fibrocyte Infiltration
Am. J. Pathol., March 1, 2007; 170(3): 843 - 854.
[Abstract] [Full Text] [PDF]


Home page
Stem CellsHome page
J. Li, J. A. Deane, N. V. Campanale, J. F. Bertram, and S. D. Ricardo
The Contribution of Bone Marrow-Derived Cells to the Development of Renal Interstitial Fibrosis
Stem Cells, March 1, 2007; 25(3): 697 - 706.
[Abstract] [Full Text] [PDF]


Home page
Nephrol Dial TransplantHome page
I. M. Wahba, K. White, M. Meyer, and E. L. Simpson
The case for ultraviolet light therapy in nephrogenic fibrosing dermopathy--report of two cases and review of the literature
Nephrol. Dial. Transplant., February 1, 2007; 22(2): 631 - 636.
[Full Text] [PDF]


Home page
Stem CellsHome page
Q. He, C. Wan, and G. Li
Concise Review: Multipotent Mesenchymal Stromal Cells in Blood
Stem Cells, January 1, 2007; 25(1): 69 - 77.
[Abstract] [Full Text] [PDF]


Home page
J. Am. Soc. Nephrol.Home page
M. Broekema, M. C. Harmsen, M. J.A. van Luyn, J. A. Koerts, A. H. Petersen, T. G. van Kooten, H. van Goor, G. Navis, and E. R. Popa
Bone Marrow-Derived Myofibroblasts Contribute to the Renal Interstitial Myofibroblast Population and Produce Procollagen I after Ischemia/Reperfusion in Rats
J. Am. Soc. Nephrol., January 1, 2007; 18(1): 165 - 175.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Respir. Crit. Care Med.Home page
D. Kaur, R. Saunders, P. Berger, S. Siddiqui, L. Woodman, A. Wardlaw, P. Bradding, and C. E. Brightling
Airway Smooth Muscle and Mast Cell-derived CC Chemokine Ligand 19 Mediate Airway Smooth Muscle Migration in Asthma
Am. J. Respir. Crit. Care Med., December 1, 2006; 174(11): 1179 - 1188.
[Abstract] [Full Text] [PDF]


Home page
Proc. Natl. Acad. Sci. USAHome page
S. B. Haudek, Y. Xia, P. Huebener, J. M. Lee, S. Carlson, J. R. Crawford, D. Pilling, R. H. Gomer, J. Trial, N. G. Frangogiannis, et al.
Bone marrow-derived fibroblast precursors mediate ischemic cardiomyopathy in mice
PNAS, November 28, 2006; 103(48): 18284 - 18289.
[Abstract] [Full Text] [PDF]


Home page
BloodHome page
M. Ogawa, A. C. LaRue, and C. J. Drake
Hematopoietic origin of fibroblasts/myofibroblasts: its pathophysiologic implications
Blood, November 1, 2006; 108(9): 2893 - 2896.
[Abstract] [Full Text] [PDF]


Home page
Proc. Natl. Acad. Sci. USAHome page
N. Sakai, T. Wada, H. Yokoyama, M. Lipp, S. Ueha, K. Matsushima, and S. Kaneko
Secondary lymphoid tissue chemokine (SLC/CCL21)/CCR7 signaling regulates fibrocytes in renal fibrosis
PNAS, September 19, 2006; 103(38): 14098 - 14103.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Heart Circ. Physiol.Home page
T. A. Baudino, W. Carver, W. Giles, and T. K. Borg
Cardiac fibroblasts: friend or foe?
Am J Physiol Heart Circ Physiol, September 1, 2006; 291(3): H1015 - H1026.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Respir. Cell Mol. Bio.Home page
B. B. Moore, L. Murray, A. Das, C. A. Wilke, A. B. Herrygers, and G. B. Toews
The Role of CCL12 in the Recruitment of Fibrocytes and Lung Fibrosis
Am. J. Respir. Cell Mol. Biol., August 1, 2006; 35(2): 175 - 181.
[Abstract] [Full Text] [PDF]


Home page
J. Leukoc. Biol.Home page
D. Pilling, N. M. Tucker, and R. H. Gomer
Aggregated IgG inhibits the differentiation of human fibrocytes
J. Leukoc. Biol., June 1, 2006; 79(6): 1242 - 1251.
[Abstract] [Full Text] [PDF]


Home page
Circ. Res.Home page
R. P. Visconti, Y. Ebihara, A. C. LaRue, P. A. Fleming, T. C. McQuinn, M. Masuya, H. Minamiguchi, R. R. Markwald, M. Ogawa, and C. J. Drake
An In Vivo Analysis of Hematopoietic Stem Cell Potential: Hematopoietic Origin of Cardiac Valve Interstitial Cells
Circ. Res., March 17, 2006; 98(5): 690 - 696.
[Abstract] [Full Text] [PDF]


Home page
J. Leukoc. Biol.Home page
N. Sakai, T. Wada, K. Furuichi, K. Shimizu, S. Kokubo, A. Hara, J. Yamahana, T. Okumura, K. Matsushima, H. Yokoyama, et al.
MCP-1/CCR2-dependent loop for fibrogenesis in human peripheral CD14-positive monocytes
J. Leukoc. Biol., March 1, 2006; 79(3): 555 - 563.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Respir. Cell Mol. Bio.Home page
S. K. Frankel, G. P. Cosgrove, S.-I. Cha, C. D. Cool, M. W. Wynes, B. L. Edelman, K. K. Brown, and D. W. H. Riches
TNF-{alpha} Sensitizes Normal and Fibrotic Human Lung Fibroblasts to Fas-Induced Apoptosis
Am. J. Respir. Cell Mol. Biol., March 1, 2006; 34(3): 293 - 304.
[Abstract] [Full Text] [PDF]


Home page
GutHome page
S J Leedham, M Brittan, S L Preston, S A C McDonald, and N A Wright
The stomach periglandular fibroblast sheath: all present and correct
Gut, February 1, 2006; 55(2): 295 - 296.
[Full Text] [PDF]


Home page
Cancer Res.Home page
N. C. Direkze, R. Jeffery, K. Hodivala-Dilke, T. Hunt, R. J. Playford, G. Elia, R. Poulsom, N. A. Wright, and M. R. Alison
Bone Marrow-Derived Stromal Cells Express Lineage-Related Messenger RNA Species
Cancer Res., February 1, 2006; 66(3): 1265 - 1269.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Pathol.Home page
M. Anghelina, P. Krishnan, L. Moldovan, and N. I. Moldovan
Monocytes/Macrophages Cooperate with Progenitor Cells during Neovascularization and Tissue Repair: Conversion of Cell Columns into Fibrovascular Bundles
Am. J. Pathol., February 1, 2006; 168(2): 529 - 541.
[Abstract] [Full Text] [PDF]


Home page
Proc Am Thorac SocHome page
V. N. Lama and S. H. Phan
The extrapulmonary origin of fibroblasts: stem/progenitor cells and beyond.
Proceedings of the ATS, January 1, 2006; 3(4): 373 - 376.
[Abstract] [Full Text] [PDF]


Home page
J. Clin. Pathol.Home page
E S Choi, E M Pierce, C Jakubzick, K J Carpenter, S L Kunkel, H Evanoff, F J Martinez, K R Flaherty, B B Moore, G B Toews, et al.
Focal interstitial CC chemokine receptor 7 (CCR7) expression in idiopathic interstitial pneumonia
J. Clin. Pathol., January 1, 2006; 59(1): 28 - 39.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Pathol.Home page
J. L. Faulkner, L. M. Szcykalski, F. Springer, and J. L. Barnes
Origin of Interstitial Fibroblasts in an Accelerated Model of Angiotensin II-Induced Renal Fibrosis
Am. J. Pathol., November 1, 2005; 167(5): 1193 - 1205.
[Abstract] [Full Text] [PDF]


Home page
JDRHome page
H.E. van Beurden, J.W. Von den Hoff, R. Torensma, J.C. Maltha, and A.M. Kuijpers-Jagtman
Myofibroblasts in Palatal Wound Healing: Prospects for the Reduction of Wound Contraction after Cleft Palate Repair
Journal of Dental Research, October 1, 2005; 84(10): 871 - 880.
[Abstract] [Full Text] [PDF]


Home page
J. Leukoc. Biol.Home page
C. Balmelli, N. Ruggli, K. McCullough, and A. Summerfield
Fibrocytes are potent stimulators of anti-virus cytotoxic T cells
J. Leukoc. Biol., June 1, 2005; 77(6): 923 - 933.
[Abstract] [Full Text] [PDF]


Home page
Arterioscler. Thromb. Vasc. Bio.Home page
M. R. Hoenig, G. R. Campbell, B. E. Rolfe, and J. H. Campbell
Tissue-Engineered Blood Vessels: Alternative to Autologous Grafts?
Arterioscler. Thromb. Vasc. Biol., June 1, 2005; 25(6): 1128 - 1134.
[Abstract] [Full Text] [PDF]


Home page
Stem CellsHome page
G. Ishii, T. Sangai, K. Sugiyama, T. Ito, T. Hasebe, Y. Endoh, J. Magae, and A. Ochiai
In Vivo Characterization of Bone Marrow-Derived Fibroblasts Recruited into Fibrotic Lesions
Stem Cells, May 1, 2005; 23(5): 699 - 706.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Pathol.Home page
B. B. Moore, J. E. Kolodsick, V. J. Thannickal, K. Cooke, T. A. Moore, C. Hogaboam, C. A. Wilke, and G. B. Toews
CCR2-Mediated Recruitment of Fibrocytes to the Alveolar Space after Fibrotic Injury
Am. J. Pathol., March 1, 2005; 166(3): 675 - 684.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Pathol.Home page
Y. Shi, B. Reitmaier, J. Regenbogen, R. M. Slowey, S. R. Opalenik, E. Wolf, A. Goppelt, and J. M. Davidson
CARP, a Cardiac Ankyrin Repeat Protein, Is Up-Regulated during Wound Healing and Induces Angiogenesis in Experimental Granulation Tissue
Am. J. Pathol., January 1, 2005; 166(1): 303 - 312.
[Abstract] [Full Text] [PDF]


Home page
Cardiovasc ResHome page
P. Camelliti, T. K. Borg, and P. Kohl
Structural and functional characterisation of cardiac fibroblasts
Cardiovasc Res, January 1, 2005; 65(1): 40 - 51.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
N. C. Direkze, K. Hodivala-Dilke, R. Jeffery, T. Hunt, R. Poulsom, D. Oukrif, M. R. Alison, and N. A. Wright
Bone Marrow Contribution to Tumor-Associated Myofibroblasts and Fibroblasts
Cancer Res., December 1, 2004; 64(23): 8492 - 8495.
[Abstract] [Full Text] [PDF]


Home page
Arterioscler. Thromb. Vasc. Bio.Home page
L. Zhang, K. Peppel, L. Brian, L. Chien, and N. J. Freedman
Vein Graft Neointimal Hyperplasia Is Exacerbated by Tumor Necrosis Factor Receptor-1 Signaling in Graft-Intrinsic Cells
Arterioscler. Thromb. Vasc. Biol., December 1, 2004; 24(12): 2277 - 2283.
[Abstract] [Full Text] [PDF]


Home page
Ann Rheum DisHome page
C D Buckley, A Filer, O Haworth, G Parsonage, and M Salmon
Defining a role for fibroblasts in the persistence of chronic inflammatory joint disease
Ann Rheum Dis, November 1, 2004; 63(suppl_2): ii92 - ii95.
[Abstract] [Full Text] [PDF]


Home page
Stem CellsHome page
C. Fathke, L. Wilson, J. Hutter, V. Kapoor, A. Smith, A. Hocking, and F. Isik
Contribution of Bone Marrow-Derived Cells to Skin: Collagen Deposition and Wound Repair
Stem Cells, September 1, 2004; 22(5): 812 - 822.
[Abstract] [Full Text] [PDF]


Home page
Arterioscler. Thromb. Vasc. Bio.Home page
T. J. Rabelink, H. C. de Boer, E. J.P. de Koning, and A.-J. van Zonneveld
Endothelial Progenitor Cells: More Than an Inflammatory Response?
Arterioscler. Thromb. Vasc. Biol., May 1, 2004; 24(5): 834 - 838.
[Abstract] [Full Text]


Home page
Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
N. J. Davie, J. T. Crossno Jr., M. G. Frid, S. E. Hofmeister, J. T. Reeves, D. M. Hyde, T. C. Carpenter, J. A. Brunetti, I. K. McNiece, and K. R. Stenmark
Hypoxia-induced pulmonary artery adventitial remodeling and neovascularization: contribution of progenitor cells
Am J Physiol Lung Cell Mol Physiol, April 1, 2004; 286(4): L668 - L678.
[Abstract] [Full Text] [PDF]


Home page
CirculationHome page
P. M. Mourani, P. J. Garl, J. M. Wenzlau, T. C. Carpenter, K. R. Stenmark, and M. C.M. Weiser-Evans
Unique, Highly Proliferative Growth Phenotype Expressed by Embryonic and Neointimal Smooth Muscle Cells Is Driven by Constitutive Akt, mTOR, and p70S6K Signaling and Is Actively Repressed by PTEN
Circulation, March 16, 2004; 109(10): 1299 - 1306.
[Abstract] [Full Text] [PDF]


Home page
Arterioscler. Thromb. Vasc. Bio.Home page
L. Zhang, N. J. Freedman, L. Brian, and K. Peppel
Graft-Extrinsic Cells Predominate in Vein Graft Arterialization
Arterioscler. Thromb. Vasc. Biol., March 1, 2004; 24(3): 470 - 476.
[Abstract] [Full Text]


Home page
Am. J. Pathol.Home page
Y. Li, W. Foster, B. M. Deasy, Y. Chan, V. Prisk, Y. Tang, J. Cummins, and J. Huard
Transforming Growth Factor-{beta}1 Induces the Differentiation of Myogenic Cells into Fibrotic Cells in Injured Skeletal Muscle: A Key Event in Muscle Fibrogenesis
Am. J. Pathol., March 1, 2004; 164(3): 1007 - 1019.
[Abstract] [Full Text] [PDF]


Home page
J. Am. Soc. Nephrol.Home page
H. Robertson, S. Ali, B. J. McDonnell, A. D. Burt, and J. A. Kirby
Chronic Renal Allograft Dysfunction: The Role of T Cell-Mediated Tubular Epithelial to Mesenchymal Cell Transition
J. Am. Soc. Nephrol., February 1, 2004; 15(2): 390 - 397.
[Abstract] [Full Text] [PDF]


Home page
Stem CellsHome page
M. Niku, L. Ilmonen, T. Pessa-Morikawa, and A. Iivanainen
Limited Contribution of Circulating Cells to the Development and Maintenance of Nonhematopoietic Bovine Tissues
Stem Cells, January 1, 2004; 22(1): 12 - 20.
[Abstract] [Full Text] [PDF]


Home page
JEMHome page
T. Schuler, S. Kornig, and T. Blankenstein
Tumor Rejection by Modulation of Tumor Stromal Fibroblasts
J. Exp. Med., November 17, 2003; 198(10): 1487 - 1493.
[Abstract] [Full Text] [PDF]


Home page
J. Immunol.Home page
D. Pilling, C. D. Buckley, M. Salmon, and R. H. Gomer
Inhibition of Fibrocyte Differentiation by Serum Amyloid P
J. Immunol., November 15, 2003; 171(10): 5537 - 5546.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Respir. Cell Mol. Bio.Home page
N. Kaminski, J. A. Belperio, P. B. Bitterman, L. Chen, S. W. Chensue, A. M.K. Choi, S. Dacic, J. H. Dauber, R. M. du Bois, J. J. Enghild, et al.
Idiopathic Pulmonary Fibrosis
Am. J. Respir. Cell Mol. Biol., September 1, 2003; 29(3): S1 - 105.
[Full Text] [PDF]


Home page
Stem CellsHome page
N. C. Direkze, S. J. Forbes, M. Brittan, T. Hunt, R. Jeffery, S. L. Preston, R. Poulsom, K. Hodivala-Dilke, M. R. Alison, and N. A. Wright
Multiple Organ Engraftment by Bone-Marrow-Derived Myofibroblasts and Fibroblasts in Bone-Marrow-Transplanted Mice
Stem Cells, September 1, 2003; 21(5): 514 - 520.
[Abstract] [Full Text] [PDF]


Home page
J. Immunol.Home page
M. Schmidt, G. Sun, M. A. Stacey, L. Mori, and S. Mattoli
Identification of Circulating Fibrocytes as Precursors of Bronchial Myofibroblasts in Asthma
J. Immunol., July 1, 2003; 171(1): 380 - 389.
[Abstract] [Full Text] [PDF]


Home page
INT J LOW EXTREM WOUNDSHome page
T. P. Amadeu, B. Coulomb, A. Desmouliere, and A. M. A. Costa
Cutaneous Wound Healing: Myofibroblastic Differentiation and in Vitro Models
International Journal of Lower Extremity Wounds, June 1, 2003; 2(2): 60 - 68.
[Abstract] [PDF]


Home page
J. Clin. Endocrinol. Metab.Home page
M. Kimatrai, C. Oliver, A. C. Abadia-Molina, J. M. Garcia-Pacheco, and E. G. Olivares
Contractile Activity of Human Decidual Stromal Cells
J. Clin. Endocrinol. Metab., February 1, 2003; 88(2): 844 - 849.
[Abstract] [Full Text] [PDF]


Home page
J. Clin. Pathol.Home page
H Nakayama, H Enzan, E Miyazaki, and M Toi
{alpha} Smooth muscle actin positive stromal cells in gastric carcinoma
J. Clin. Pathol., October 1, 2002; 55(10): 741 - 744.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Pathol.Home page
Y. Li and J. Huard
Differentiation of Muscle-Derived Cells into Myofibroblasts in Injured Skeletal Muscle
Am. J. Pathol., September 1, 2002; 161(3): 895 - 907.
[Abstract] [Full Text] [PDF]


Home page
GutHome page
M Brittan, T Hunt, R Jeffery, R Poulsom, S J Forbes, K Hodivala-Dilke, J Goldman, M R Alison, and N A Wright
Bone marrow derivation of pericryptal myofibroblasts in the mouse and human small intestine and colon
Gut, June 1, 2002; 50(6): 752 - 757.
[Abstract] [Full Text] [PDF]


Home page
J. Immunol.Home page
N. Scholler, M. Hayden-Ledbetter, A. Dahlin, I. Hellstrom, K. E. Hellstrom, and J. A. Ledbetter
Cutting Edge: CD83 Regulates the Development of Cellular Immunity
J. Immunol., March 15, 2002; 168(6): 2599 - 2602.
[Abstract] [Full Text] [PDF]


Home page
FASEB J.Home page
I. HARTLAPP, R. ABE, R. W. SAEED, T. PENG, W. VOELTER, R. BUCALA, and C. N. METZ
Fibrocytes induce an angiogenic phenotype in cultured endothelial cells and promote angiogenesis in vivo
FASEB J, October 1, 2001; 15(12): 2215 - 2224.
[Abstract] [Full Text] [PDF]




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 2001 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 2001 by The American Association of Immunologists, Inc. All rights reserved.